(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioblastoma | D005909 | 27 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Glei M et al. | Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cells. | 2003 Oct-Dec | Toxicol In Vitro | pmid:14599469 |
| Ludwig A et al. | The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15033450 |
| Zhang L et al. | Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. | 2004 | Int J Pharm | pmid:15541906 |
| Hayakawa F et al. | Prooxidative activities of tea catechins in the presence of Cu2+. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15388955 |
| Koyama Y et al. | Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo. | 2004 | Planta Med. | pmid:15549673 |
| Lee K | Transactivation of peroxisome proliferator-activated receptor alpha by green tea extracts. | 2004 | J. Vet. Sci. | pmid:15613816 |
| Koparal AT et al. | Differential effect of green tea catechins on three endothelial cell clones isolated from rat adipose tissue and on human umbilical vein endothelial cells. | 2004 | Cytotechnology | pmid:19003256 |
| Apak R et al. | Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. | 2004 | J. Agric. Food Chem. | pmid:15612784 |
| Taguri T et al. | Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease. | 2004 | Biol. Pharm. Bull. | pmid:15577214 |
| Furuyashiki T et al. | Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15564676 |
| Garbacki N et al. | Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats. | 2004 | BMC Pharmacol. | pmid:15498105 |
| Mori A et al. | Natural antioxidants may prevent posttraumatic epilepsy: a proposal based on experimental animal studies. | 2004 | Acta Med. Okayama | pmid:15471432 |
| Tsuneki H et al. | Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. | 2004 | BMC Pharmacol. | pmid:15331020 |
| Wang R and Zhou W | Stability of tea catechins in the breadmaking process. | 2004 | J. Agric. Food Chem. | pmid:15612821 |
| Morimitsu Y et al. | Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations. | 2004 | Biol. Pharm. Bull. | pmid:15133252 |
| Limer JL and Speirs V | Phyto-oestrogens and breast cancer chemoprevention. | 2004 | Breast Cancer Res. | pmid:15084232 |
| Miyamoto Y et al. | Cellular toxicity of catechin analogues containing gallate in opossum kidney proximal tubular (OK) cells. | 2004 | J Toxicol Sci | pmid:15018154 |
| Jeong JH et al. | Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine. | 2004 | Toxicology | pmid:14698567 |
| Sakanaka S and Okada Y | Inhibitory effects of green tea polyphenols on the production of a virulence factor of the periodontal-disease-causing anaerobic bacterium Porphyromonas gingivalis. | 2004 | J. Agric. Food Chem. | pmid:15030231 |
| Punyasiri PA et al. | Flavonoid biosynthesis in the tea plant Camellia sinensis: properties of enzymes of the prominent epicatechin and catechin pathways. | 2004 | Arch. Biochem. Biophys. | pmid:15464723 |
| Sivakumaran S et al. | Variation in antimicrobial action of proanthocyanidins from Dorycnium rectum against rumen bacteria. | 2004 | Phytochemistry | pmid:15381413 |
| Chu KO et al. | Determination of catechins and catechin gallates in tissues by liquid chromatography with coulometric array detection and selective solid phase extraction. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15380714 |
| Kodama S et al. | Direct enantioseparation of catechin and epicatechin in tea drinks by 6-O-alpha-D-glucosyl-beta-cyclodextrin-modified micellar electrokinetic chromatography. | 2004 | Electrophoresis | pmid:15352024 |
| Chisholm K et al. | Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells. | 2004 | Anticancer Drugs | pmid:15457130 |
| Kim DO and Lee CY | Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. | 2004 | Crit Rev Food Sci Nutr | pmid:15462129 |
| Katsube T et al. | Screening for antioxidant activity in edible plant products: comparison of low-density lipoprotein oxidation assay, DPPH radical scavenging assay, and Folin-Ciocalteu assay. | 2004 | J. Agric. Food Chem. | pmid:15080652 |
| Le Gall G et al. | Metabolite profiling using (1)H NMR spectroscopy for quality assessment of green tea, Camellia sinensis (L.). | 2004 | J. Agric. Food Chem. | pmid:14969518 |
| Kitagawa S et al. | Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells. | 2004 | J. Pharm. Pharmacol. | pmid:15285844 |
| Kuo YC et al. | Isolation and immunomodulatory effect of flavonoids from Syzygium samarangense. | 2004 | Planta Med. | pmid:15643565 |
| Xu JZ et al. | Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. | 2004 | Br. J. Nutr. | pmid:15182391 |
| Takano K et al. | Inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. | 2004 | J. Agric. Food Chem. | pmid:15237969 |
| Koh SH et al. | Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals. | 2004 | Toxicology | pmid:15337584 |
| Kimata H | Effect of viewing a humorous vs. nonhumorous film on bronchial responsiveness in patients with bronchial asthma. | 2004 | Physiol. Behav. | pmid:15178163 |
| Watson JL et al. | Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15231486 |
| Yokozawa T and Nakagawa T | Inhibitory effects of Luobuma tea and its components against glucose-mediated protein damage. | 2004 | Food Chem. Toxicol. | pmid:15110107 |
| Ichiyanagi T et al. | Absorption and metabolism of delphinidin 3-O-beta-D-glucopyranoside in rats. | 2004 | Free Radic. Biol. Med. | pmid:15019977 |
| Jorgensen EM et al. | Analysis of the oxidative degradation of proanthocyanidins under basic conditions. | 2004 | J. Agric. Food Chem. | pmid:15080635 |
| Nakagawa T et al. | Activity of (-)-epigallocatechin 3-O-gallate against oxidative stress in rats with adenine-induced renal failure. | 2004 | J. Agric. Food Chem. | pmid:15053559 |
| Sugisawa A et al. | Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells. | 2004 | Mutat. Res. | pmid:15066578 |
| Sivakumaran S et al. | Floral procyanidins of the forage legume red clover (Trifolium pratense L.). | 2004 | J. Agric. Food Chem. | pmid:15030214 |
| Nakagawa H et al. | Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate. | 2004 | Carcinogenesis | pmid:15090467 |
| Nimal Punyasiri PA et al. | Exobasidium vexans infection of Camellia sinensis increased 2,3-cis isomerisation and gallate esterification of proanthocyanidins. | 2004 | Phytochemistry | pmid:15504433 |
| Arakawa H et al. | Role of hydrogen peroxide in bactericidal action of catechin. | 2004 | Biol. Pharm. Bull. | pmid:14993788 |
| Shui G and Peng LL | An improved method for the analysis of major antioxidants of Hibiscus esculentus Linn. | 2004 | J Chromatogr A | pmid:15453414 |
| Okamoto M et al. | Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis. | 2004 | Oral Microbiol. Immunol. | pmid:14871352 |
| Zheng Y et al. | Inhibitory effect of epigallocatechin 3-O-gallate on vascular smooth muscle cell hypertrophy induced by angiotensin II. | 2004 | J. Cardiovasc. Pharmacol. | pmid:14716206 |
| Aneja R et al. | Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. | 2004 Jan-Jun | Mol. Med. | pmid:15502883 |
| Lyu SY and Park WB | Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. | 2005 | Arch. Pharm. Res. | pmid:15974445 |
| Mizushina Y et al. | Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15950188 |
| Hayashi N et al. | Reduction of catechin astringency by the complexation of gallate-type catechins with pectin. | 2005 | Biosci. Biotechnol. Biochem. | pmid:16041135 |