(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioblastoma | D005909 | 27 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lyu SY and Park WB | Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. | 2005 | Arch. Pharm. Res. | pmid:15974445 |
| Mukai K et al. | Structure-activity relationship of the tocopherol-regeneration reaction by catechins. | 2005 | Free Radic. Biol. Med. | pmid:15808422 |
| Proctor GB et al. | Salivary proteins interact with dietary constituents to modulate tooth staining. | 2005 | J. Dent. Res. | pmid:15615880 |
| Navarro RE et al. | Complexation of epigallocatechin gallate (a green tea extract, egcg) with Mn2+: nuclear spin relaxation by the paramagnetic ion. | 2005 | J. Inorg. Biochem. | pmid:15621293 |
| Mizushina Y et al. | Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15950188 |
| Ozcan A et al. | Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced cystitis in rats. | 2005 | Arch. Toxicol. | pmid:15800758 |
| Yao L et al. | Seasonal variations of phenolic compounds in Australia-grown tea (Camellia sinensis). | 2005 | J. Agric. Food Chem. | pmid:16076137 |
| Kumar NS and Rajapaksha M | Separation of catechin constituents from five tea cultivars using high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:16078712 |
| Nakai M et al. | Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. | 2005 | J. Agric. Food Chem. | pmid:15913331 |
| Herrero M et al. | Pressurized liquid extraction-capillary electrophoresis-mass spectrometry for the analysis of polar antioxidants in rosemary extracts. | 2005 | J Chromatogr A | pmid:16114236 |
| Hayashi N et al. | Reduction of catechin astringency by the complexation of gallate-type catechins with pectin. | 2005 | Biosci. Biotechnol. Biochem. | pmid:16041135 |
| Mukai K et al. | Kinetic study of the quenching reaction of singlet oxygen by tea catechins in ethanol solution. | 2005 | Free Radic. Biol. Med. | pmid:16109305 |
| Yang C et al. | Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. | 2005 | Toxicology | pmid:16085347 |
| Ikeda I et al. | Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats. | 2005 | J. Nutr. | pmid:15671206 |
| Chen D et al. | Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. | 2005 | Biochem. Pharmacol. | pmid:15857617 |
| Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
| Nakamuta M et al. | Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells. | 2005 | Int. J. Mol. Med. | pmid:16142404 |
| Hung PF et al. | Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15647388 |
| Arendt BM et al. | Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). | 2005 | Nutr J | pmid:16287499 |
| Chow HH et al. | Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. | 2005 | Clin. Cancer Res. | pmid:15958649 |
| Huang HY and Lien WC | Analyses of phenolic compounds by microemulsion electrokinetic chromatography. | 2005 | Electrophoresis | pmid:16041702 |
| Anger DL et al. | Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols. | 2005 | Br. J. Pharmacol. | pmid:15895106 |
| Baek WK et al. | Inhibitory modulation of ATP-sensitive potassium channels by gallate-ester moiety of (-)-epigallocatechin-3-gallate. | 2005 | Biochem. Pharmacol. | pmid:16216226 |
| Backleh-Sohrt M et al. | Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials. | 2005 | J. Nat. Prod. | pmid:16180819 |
| Zhou ZH et al. | Puerins A and B, two new 8-C substituted flavan-3-ols from Pu-er tea. | 2005 | J. Agric. Food Chem. | pmid:16248561 |
| Cortell JM et al. | Influence of vine vigor on grape (Vitis vinifera L. Cv. Pinot Noir) and wine proanthocyanidins. | 2005 | J. Agric. Food Chem. | pmid:15998151 |
| Mazauric JP and Salmon JM | Interactions between yeast lees and wine polyphenols during simulation of wine aging: I. Analysis of remnant polyphenolic compounds in the resulting wines. | 2005 | J. Agric. Food Chem. | pmid:15998128 |
| Netsch MI et al. | Inhibitory activity of a green tea extract and some of its constituents on multidrug resistance-associated protein 2 functionality. | 2005 | Planta Med. | pmid:15729621 |
| Lee YK et al. | VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance. | 2005 | Leukemia | pmid:15703780 |
| Zhou B et al. | Evidence for alpha-tocopherol regeneration reaction of green tea polyphenols in SDS micelles. | 2005 | Free Radic. Biol. Med. | pmid:15589374 |
| Vovk I et al. | Separation of eight selected flavan-3-ols on cellulose thin-layer chromatographic plates. | 2005 | J Chromatogr A | pmid:16001555 |
| Di Paola R et al. | Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. | 2005 | Respir. Res. | pmid:15987519 |
| Punyasiri PA et al. | Preformed and induced chemical resistance of tea leaf against Exobasidium vexans infection. | 2005 | J. Chem. Ecol. | pmid:16222773 |
| McDougall GJ et al. | Anthocyanin-flavanol condensation products from black currant (Ribes nigrum L.). | 2005 | J. Agric. Food Chem. | pmid:16190645 |
| Feucht W et al. | Flavanols in somatic cell division and male meiosis of tea (Camellia sinensis) anthers. | 2005 | Plant Biol (Stuttg) | pmid:15822012 |
| Tanaka T et al. | Regioselectivity in benzotropolone formation between catechins and proanthocyanidins. | 2005 | Nat. Prod. Res. | pmid:16320425 |
| Agusta A et al. | Stereoselective oxidation at C-4 of flavans by the endophytic fungus Diaporthe sp. isolated from a tea plant. | 2005 | Chem. Pharm. Bull. | pmid:16327190 |
| Kawai K | Comment on inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. | 2005 | J. Agric. Food Chem. | pmid:15713057 |
| Doss MX et al. | Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases. | 2005 | J. Nutr. Biochem. | pmid:15866224 |
| Kim M et al. | (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. | 2005 | Carcinogenesis | pmid:15860507 |
| Song JM et al. | Antiviral effect of catechins in green tea on influenza virus. | 2005 | Antiviral Res. | pmid:16137775 |
| Gyémánt N et al. | In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. | 2005 Mar-Apr | In Vivo | pmid:15796199 |
| Naka T et al. | Modulation of branching morphogenesis of fetal mouse submandibular gland by sodium ascorbate and epigallocatechin gallate. | 2005 Sep-Oct | In Vivo | pmid:16097443 |
| Masukawa Y et al. | Determination of green tea catechins in human plasma using liquid chromatography-electrospray ionization mass spectrometry. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16513433 |
| Actis-Goretta L et al. | Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. | 2006 | J. Agric. Food Chem. | pmid:16390204 |
| Seeram NP et al. | Catechin and caffeine content of green tea dietary supplements and correlation with antioxidant capacity. | 2006 | J. Agric. Food Chem. | pmid:16506807 |
| Bastianetto S et al. | Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. | 2006 | Eur. J. Neurosci. | pmid:16420415 |
| Lee SC et al. | Effect of far-infrared irradiation on catechins and nitrite scavenging activity of green tea. | 2006 | J. Agric. Food Chem. | pmid:16417296 |
| Harnly JM et al. | Flavonoid content of U.S. fruits, vegetables, and nuts. | 2006 | J. Agric. Food Chem. | pmid:17177529 |
| Bigelow RL and Cardelli JA | The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells. | 2006 | Oncogene | pmid:16449979 |