(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioblastoma | D005909 | 27 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Green RJ et al. | Common tea formulations modulate in vitro digestive recovery of green tea catechins. | 2007 | Mol Nutr Food Res | pmid:17688297 |
| Niemeyer ED and Brodbelt JS | Isomeric differentiation of green tea catechins using gas-phase hydrogen/deuterium exchange reactions. | 2007 | J. Am. Soc. Mass Spectrom. | pmid:17702600 |
| Song JM et al. | Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives. | 2007 | Antiviral Res. | pmid:17709148 |
| Lin CL et al. | Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. | 2007 | J. Lipid Res. | pmid:17720960 |
| Matsuo Y et al. | Enzymatic oxidation of gallocatechin and epigallocatechin: effects of C-ring configuration on the reaction products. | 2008 | Phytochemistry | pmid:17888464 |
| Wang JS et al. | Validation of green tea polyphenol biomarkers in a phase II human intervention trial. | 2008 | Food Chem. Toxicol. | pmid:17888558 |
| Neilson AP et al. | Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion. | 2007 | J. Agric. Food Chem. | pmid:17924707 |
| Li W et al. | A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. | 2007 | PLoS ONE | pmid:17987129 |
| Nguyen M et al. | Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18040043 |
| Letchoumy PV et al. | Comparative evaluation of antiproliferative, antiangiogenic and apoptosis inducing potential of black tea polyphenols in the hamster buccal pouch carcinogenesis model. | 2007 | J Carcinog | pmid:18053169 |
| Niedzwiecki A | Micronutrient mixture in tumor growth and metastasis. | 2008 | Pediatr Blood Cancer | pmid:18061931 |
| Yang SW et al. | Protective effects of epigallocatechin gallate after UV irradiation in cultured human retinal pigment epithelial cells. | 2007 | Korean J Ophthalmol | pmid:18063889 |
| Kuzuhara T et al. | Green tea catechin as a chemical chaperone in cancer prevention. | 2008 | Cancer Lett. | pmid:18068893 |
| Wu Q et al. | Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu). | 2007 | Chem. Biodivers. | pmid:18081092 |
| Shen CL et al. | Protective effect of green tea polyphenols on bone loss in middle-aged female rats. | 2008 | Osteoporos Int | pmid:18084689 |
| Kajiya K et al. | Solid-state NMR analysis of the orientation and dynamics of epigallocatechin gallate, a green tea polyphenol, incorporated into lipid bilayers. | 2008 | Magn Reson Chem | pmid:18098154 |
| Neyestani TR et al. | Selective microbiologic effects of tea extract on certain antibiotics against Escherichia coli in vitro. | 2007 | J Altern Complement Med | pmid:18166124 |
| Inaba H et al. | Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (--)-epigallocatechin against HCT116 colorectal carcinoma cells. | 2008 | Biol. Pharm. Bull. | pmid:18175946 |
| Amici M et al. | Wheat sprout extract induces changes on 20S proteasomes functionality. | 2008 | Biochimie | pmid:18190797 |
| Zhu BT et al. | Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (-)-epigallocatechin-3-O-gallate. | 2008 | Xenobiotica | pmid:18197555 |
| Jin YR et al. | Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209568 |
| Son YH et al. | Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209571 |
| Chen XN et al. | Radical scavenging activity and phenolic compounds in persimmon (Diospyros kaki L. cv. Mopan). | 2008 | J. Food Sci. | pmid:18211345 |
| de Souza LM et al. | HPLC/ESI-MS and NMR analysis of flavonoids and tannins in bioactive extract from leaves of Maytenus ilicifolia. | 2008 | J Pharm Biomed Anal | pmid:18215490 |
| Devika PT and Mainzen Prince PS | (-)-Epigallocatechin gallate (EGCG) prevents isoprenaline-induced cardiac marker enzymes and membrane-bound ATPases. | 2008 | J. Pharm. Pharmacol. | pmid:18251087 |
| Shim JS et al. | The effects of panduratin A isolated from Kaempferia pandurata on the expression of matrix metalloproteinase-1 and type-1 procollagen in human skin fibroblasts. | 2008 | Planta Med. | pmid:18253916 |
| Zhang B et al. | Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro. | 2008 | Brain Res. | pmid:18255049 |
| Sasazuki S et al. | Plasma tea polyphenols and gastric cancer risk: a case-control study nested in a large population-based prospective study in Japan. | 2008 | Cancer Epidemiol. Biomarkers Prev. | pmid:18268118 |
| Haque AM et al. | Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats. | 2008 | J. Nutr. Biochem. | pmid:18280729 |
| Shin ES et al. | Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. | 2008 | Bioorg. Med. Chem. | pmid:18313308 |
| Sánchez-del-Campo L et al. | Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate. | 2008 | J. Med. Chem. | pmid:18324763 |
| Yao K et al. | Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent apoptosis in human lens epithelial cells. | 2008 | Mol. Vis. | pmid:18334937 |
| Pietrovski EF et al. | Topical anti-inflammatory activity of Eugenia brasiliensis Lam. (Myrtaceae) leaves. | 2008 | J. Pharm. Pharmacol. | pmid:18380921 |
| Zhang H et al. | Improving sensitivity by large-volume sample stacking combined with sweeping without polarity switching by capillary electrophoresis coupled to photodiode array ultraviolet detection. | 2008 | Electrophoresis | pmid:18384029 |
| Mukai D et al. | Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans. | 2008 | J Nat Med | pmid:18404315 |
| Hazgui S et al. | Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells. | 2008 | Respir. Res. | pmid:18426555 |
| Sang S et al. | Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18433082 |
| Wang K et al. | Preparative isolation and purification of theaflavins and catechins by high-speed countercurrent chromatography. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18436487 |
| Kuzuhara T et al. | Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate. | 2008 | Biol. Pharm. Bull. | pmid:18451499 |
| Zhong K et al. | Enzymatic production of epigallocatechin by using an epigallocatechin gallate hydrolase induced from Aspergillus oryzae. | 2008 May-Jun | Biotechnol. Prog. | pmid:18452340 |
| Cheruiyot EK et al. | Shoot epicatechin and epigallocatechin contents respond to water stress in tea [Camellia sinensis (L.) O. Kuntze]. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18460799 |
| Bandele OJ et al. | Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. | 2008 | Chem. Res. Toxicol. | pmid:18461976 |
| Nomura S et al. | Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue. | 2008 | J. Nutr. Biochem. | pmid:18479902 |
| Ortiz J et al. | Interaction of environmental moisture with powdered green tea formulations: effect on catechin chemical stability. | 2008 | J. Agric. Food Chem. | pmid:18489105 |
| Mitani S et al. | Stopped-flow kinetic study of the aroxyl radical-scavenging action of catechins and vitamin C in ethanol and micellar solutions. | 2008 | J. Agric. Food Chem. | pmid:18500808 |
| Kawai Y et al. | Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage. | 2008 | Chem. Res. Toxicol. | pmid:18512968 |
| Moon HS et al. | Physico-chemical modifications of conjugated linoleic acid for ruminal protection and oxidative stability. | 2008 | Nutr Metab (Lond) | pmid:18513443 |
| Neukam K et al. | Tea flavanols inhibit cell growth and DNA topoisomerase II activity and induce endoreduplication in cultured Chinese hamster cells. | 2008 | Mutat. Res. | pmid:18541453 |
| Hisamura F et al. | Synergistic effect of green tea polyphenols on their protection against FK506-induced cytotoxicity in renal cells. | 2008 | Am. J. Chin. Med. | pmid:18543393 |
| Dai F et al. | Antioxidant synergism of green tea polyphenols with alpha-tocopherol and L-ascorbic acid in SDS micelles. | 2008 | Biochimie | pmid:18554517 |