(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioblastoma | D005909 | 27 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shen CL et al. | Protective effect of green tea polyphenols on bone loss in middle-aged female rats. | 2008 | Osteoporos Int | pmid:18084689 |
| Niedzwiecki A | Micronutrient mixture in tumor growth and metastasis. | 2008 | Pediatr Blood Cancer | pmid:18061931 |
| Devika PT and Mainzen Prince PS | (-)-Epigallocatechin gallate (EGCG) prevents isoprenaline-induced cardiac marker enzymes and membrane-bound ATPases. | 2008 | J. Pharm. Pharmacol. | pmid:18251087 |
| Zhang B et al. | Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro. | 2008 | Brain Res. | pmid:18255049 |
| Pietrovski EF et al. | Topical anti-inflammatory activity of Eugenia brasiliensis Lam. (Myrtaceae) leaves. | 2008 | J. Pharm. Pharmacol. | pmid:18380921 |
| Neukam K et al. | Tea flavanols inhibit cell growth and DNA topoisomerase II activity and induce endoreduplication in cultured Chinese hamster cells. | 2008 | Mutat. Res. | pmid:18541453 |
| Ortiz J et al. | Interaction of environmental moisture with powdered green tea formulations: effect on catechin chemical stability. | 2008 | J. Agric. Food Chem. | pmid:18489105 |
| Markus MA and Morris BJ | Resveratrol in prevention and treatment of common clinical conditions of aging. | 2008 | Clin Interv Aging | pmid:18686754 |
| Heo J et al. | Protective effects of epigallocatechin gallate after UV irradiation of cultured human lens epithelial cells. | 2008 | Korean J Ophthalmol | pmid:18784447 |
| Wang K et al. | Preparative isolation and purification of theaflavins and catechins by high-speed countercurrent chromatography. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18436487 |
| Sang S et al. | Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18433082 |
| Kawai Y et al. | Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage. | 2008 | Chem. Res. Toxicol. | pmid:18512968 |
| Miyamoto Y et al. | (-)-Epigallocatechin 3-O-gallate (EGCG)-induced apoptosis in normal rat kidney interstitial fibroblast (NRK-49F) cells. | 2008 | J Toxicol Sci | pmid:18670168 |
| Nomura S et al. | Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue. | 2008 | J. Nutr. Biochem. | pmid:18479902 |
| Zhang H et al. | Improving sensitivity by large-volume sample stacking combined with sweeping without polarity switching by capillary electrophoresis coupled to photodiode array ultraviolet detection. | 2008 | Electrophoresis | pmid:18384029 |
| Apak R et al. | Cupric ion reducing antioxidant capacity assay for food antioxidants: vitamins, polyphenolics, and flavonoids in food extracts. | 2008 | Methods Mol. Biol. | pmid:19082947 |
| Kuzuhara T et al. | Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate. | 2008 | Biol. Pharm. Bull. | pmid:18451499 |
| Chan CM et al. | Protective effects of (-)-epigallocatechin gallate on UVA-induced damage in ARPE19 cells. | 2008 | Mol. Vis. | pmid:19119326 |
| Yu Z et al. | Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers. | 2008 | Int J Mol Sci | pmid:19325839 |
| Ogborne RM et al. | Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18586007 |
| Kajiya K et al. | Solid-state NMR analysis of the orientation and dynamics of epigallocatechin gallate, a green tea polyphenol, incorporated into lipid bilayers. | 2008 | Magn Reson Chem | pmid:18098154 |
| Mitsuhashi S et al. | Pyrogallol structure in polyphenols is involved in apoptosis-induction on HEK293T and K562 cells. | 2008 | Molecules | pmid:19052524 |
| Novo E and Parola M | Redox mechanisms in hepatic chronic wound healing and fibrogenesis. | 2008 | Fibrogenesis Tissue Repair | pmid:19014652 |
| Roberts MD et al. | Efficacy and safety of a popular thermogenic drink after 28 days of ingestion. | 2008 | J Int Soc Sports Nutr | pmid:18950510 |
| Liu J et al. | Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies. | 2008 | Chin Med | pmid:18940008 |
| Nomizu K et al. | Antioxidants from steamed used tea leaves and their reaction behavior. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18603807 |
| Moon HS et al. | Physico-chemical modifications of conjugated linoleic acid for ruminal protection and oxidative stability. | 2008 | Nutr Metab (Lond) | pmid:18513443 |
| de Souza LM et al. | HPLC/ESI-MS and NMR analysis of flavonoids and tannins in bioactive extract from leaves of Maytenus ilicifolia. | 2008 | J Pharm Biomed Anal | pmid:18215490 |
| Chen XN et al. | Radical scavenging activity and phenolic compounds in persimmon (Diospyros kaki L. cv. Mopan). | 2008 | J. Food Sci. | pmid:18211345 |
| Amici M et al. | Wheat sprout extract induces changes on 20S proteasomes functionality. | 2008 | Biochimie | pmid:18190797 |
| Shin ES et al. | Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. | 2008 | Bioorg. Med. Chem. | pmid:18313308 |
| Sánchez-del-Campo L et al. | Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate. | 2008 | J. Med. Chem. | pmid:18324763 |
| Hisamura F et al. | Synergistic effect of green tea polyphenols on their protection against FK506-induced cytotoxicity in renal cells. | 2008 | Am. J. Chin. Med. | pmid:18543393 |
| Haque AM et al. | Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats. | 2008 | J. Nutr. Biochem. | pmid:18280729 |
| Pongsuwan W et al. | High-throughput technique for comprehensive analysis of Japanese green tea quality assessment using ultra-performance liquid chromatography with time-of-flight mass spectrometry (UPLC/TOF MS). | 2008 | J. Agric. Food Chem. | pmid:18973299 |
| Shim JS et al. | The effects of panduratin A isolated from Kaempferia pandurata on the expression of matrix metalloproteinase-1 and type-1 procollagen in human skin fibroblasts. | 2008 | Planta Med. | pmid:18253916 |
| Wang H et al. | Therapeutic potential of HMGB1-targeting agents in sepsis. | 2008 | Expert Rev Mol Med | pmid:18980707 |
| Wang JS et al. | Validation of green tea polyphenol biomarkers in a phase II human intervention trial. | 2008 | Food Chem. Toxicol. | pmid:17888558 |
| Kuzuhara T et al. | Green tea catechin as a chemical chaperone in cancer prevention. | 2008 | Cancer Lett. | pmid:18068893 |
| Qian ZM et al. | Identification and quantification of free radical scavengers in Pu-erh tea by HPLC-DAD-MS coupled online with 2,2'-Azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt assay. | 2008 | J. Agric. Food Chem. | pmid:18986146 |
| Son YH et al. | Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209571 |
| Zhu BT et al. | Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (-)-epigallocatechin-3-O-gallate. | 2008 | Xenobiotica | pmid:18197555 |
| Chen Q et al. | Identification of green tea's (Camellia sinensis (L.)) quality level according to measurement of main catechins and caffeine contents by HPLC and support vector classification pattern recognition. | 2008 | J Pharm Biomed Anal | pmid:18952392 |
| Mukai D et al. | Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans. | 2008 | J Nat Med | pmid:18404315 |
| Jin YR et al. | Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209568 |
| Li C and Choi JS | Effects of epigallocatechin gallate on the bioavailability and pharmacokinetics of diltiazem in rats. | 2008 | Pharmazie | pmid:19069242 |
| Scandlyn MJ et al. | A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate. | 2008 | Br. J. Cancer | pmid:18797454 |
| Matsuo Y et al. | Enzymatic oxidation of gallocatechin and epigallocatechin: effects of C-ring configuration on the reaction products. | 2008 | Phytochemistry | pmid:17888464 |
| Lode HN et al. | Nutrient mixture including vitamin C, L-lysine, L-proline, and epigallocatechin is ineffective against tumor growth and metastasis in a syngeneic neuroblastoma model. | 2008 | Pediatr Blood Cancer | pmid:17366537 |
| Mitani S et al. | Stopped-flow kinetic study of the aroxyl radical-scavenging action of catechins and vitamin C in ethanol and micellar solutions. | 2008 | J. Agric. Food Chem. | pmid:18500808 |