(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Tsujita T et al. | α-Amylase inhibitory activity from nut seed skin polyphenols. 1. Purification and characterization of almond seed skin polyphenols. | 2013 | J. Agric. Food Chem. | pmid:23614772 |
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| Trnková L et al. | Green tea catechins can bind and modify ERp57/PDIA3 activity. | 2013 | Biochim. Biophys. Acta | pmid:23671928 |
| Ghosh S et al. | (-)-Epicatechin gallate prevents alkali-salt mediated fibrillogenesis of hen egg white lysozyme. | 2013 | Int. J. Biol. Macromol. | pmid:23219698 |
| Park JS et al. | EGCG inhibits recepteur d'origine nantais expression by suppressing Egr-1 in gastric cancer cells. | 2013 | Int. J. Oncol. | pmid:23337910 |
| Lin G et al. | Enantioselective total syntheses of (+)-gallocatechin, (-)-epigallocatechin, and 8-C-ascorbyl-(-)-epigallocatechin. | 2013 | Chem Asian J | pmid:23362126 |
| Bai LP et al. | Aminoglycosylation can enhance the G-quadruplex binding activity of epigallocatechin. | 2013 | PLoS ONE | pmid:23335983 |
| Krych J and Gebicka L | Catalase is inhibited by flavonoids. | 2013 | Int. J. Biol. Macromol. | pmid:23567286 |
| Chung JH et al. | Green tea formulations with vitamin C and xylitol on enhanced intestinal transport of green tea catechins. | 2013 | J. Food Sci. | pmid:23551173 |
| Hong YH et al. | Tannase-converted green tea catechins and their anti-wrinkle activity in humans. | 2013 | J Cosmet Dermatol | pmid:23725307 |
| Li F et al. | Inhibitory effect of catechin-related compounds on renin activity. | 2013 | Biomed. Res. | pmid:23782751 |
| Roy S et al. | Combination therapy of dexamethasone with epigallocatechin enhances tibiotarsal bone articulation and modulates oxidative status correlates with cartilage cytokines expression in the early phase of experimental arthritis. | 2013 | Eur. J. Pharmacol. | pmid:23183110 |
| Hong YH et al. | Enzymatic improvement in the polyphenol extractability and antioxidant activity of green tea extracts. | 2013 | Biosci. Biotechnol. Biochem. | pmid:23291774 |
| Zhao L et al. | Green tea catechins quench the fluorescence of bacteria-conjugated Alexa fluor dyes. | 2013 | Inflamm Allergy Drug Targets | pmid:24011199 |
| Yu SY et al. | Phenolic composition, antioxidant activity and anti-adipogenic effect of hot water extract from safflower (Carthamus tinctorius L.) seed. | 2013 | Nutrients | pmid:24288028 |
| Lee LS et al. | Optimization of ultrasonic extraction of phenolic antioxidants from green tea using response surface methodology. | 2013 | Molecules | pmid:24184822 |
| Chen XQ et al. | Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice. | 2013 | Food Funct | pmid:24056410 |
| Olšovská J et al. | Ultra-high-performance liquid chromatography profiling method for chemical screening of proanthocyanidins in Czech hops. | 2013 | Talanta | pmid:24148495 |
| Koga K et al. | Proanthocyanidin oligomers isolated from Salacia reticulata leaves potently inhibit pancreatic lipase activity. | 2013 | J. Food Sci. | pmid:23278351 |
| Cryan LM et al. | 1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2. | 2013 | J. Med. Chem. | pmid:23394144 |
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| Harakeh S et al. | Effects of nutrients on matrix metalloproteinases in human T-lymphotropic virus type 1 positive and negative malignant T-lymphocytes. | 2014 | Int. J. Oncol. | pmid:25189759 |
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| Yoshino S et al. | Effect of emulsification on the skin permeation and UV protection of catechin. | 2014 | Pharm Dev Technol | pmid:23639253 |
| Takagaki A et al. | Isolation and characterization of rat intestinal bacteria involved in biotransformation of (-)-epigallocatechin. | 2014 | Arch. Microbiol. | pmid:24947740 |
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| Xiao YH et al. | Transcriptome and biochemical analyses revealed a detailed proanthocyanidin biosynthesis pathway in brown cotton fiber. | 2014 | PLoS ONE | pmid:24466041 |
| Mocanu MM et al. | Epigallocatechin 3-O-gallate induces 67 kDa laminin receptor-mediated cell death accompanied by downregulation of ErbB proteins and altered lipid raft clustering in mammary and epidermoid carcinoma cells. | 2014 | J. Nat. Prod. | pmid:24456004 |
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| Lee EJ et al. | Hyaluronic acid/poly(lactic-co-glycolic acid) core/shell fiber meshes loaded with epigallocatechin-3-O-gallate as skin tissue engineering scaffolds. | 2014 | J Nanosci Nanotechnol | pmid:25958546 |
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| Takagaki A and Nanjo F | Effects of Metabolites Produced from (-)-Epigallocatechin Gallate by Rat Intestinal Bacteria on Angiotensin I-Converting Enzyme Activity and Blood Pressure in Spontaneously Hypertensive Rats. | 2015 | J. Agric. Food Chem. | pmid:26323573 |
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| Wong IL et al. | Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives. | 2015 | J. Med. Chem. | pmid:25985195 |
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| Takagaki A and Nanjo F | Biotransformation of (-)-epigallocatechin and (-)-gallocatechin by intestinal bacteria involved in isoflavone metabolism. | 2015 | Biol. Pharm. Bull. | pmid:25747993 |
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| Cox CJ et al. | Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. | 2015 | Neurobiol. Aging | pmid:25316600 |
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