(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kennedy DO et al. | Involvement of protein tyrosine phosphorylation in the effect of green tea polyphenols on Ehrlich ascites tumor cells in vitro. | 1998 | Chem. Biol. Interact. | pmid:9609384 |
| Nakagawa K et al. | Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9438978 |
| Stammler G and Volm M | Green tea catechins (EGCG and EGC) have modulating effects on the activity of doxorubicin in drug-resistant cell lines. | 1997 | Anticancer Drugs | pmid:9095331 |
| Yamanaka N et al. | Green tea catechins such as (-)-epicatechin and (-)-epigallocatechin accelerate Cu2+-induced low density lipoprotein oxidation in propagation phase. | 1997 | FEBS Lett. | pmid:9013893 |
| Chen L et al. | Absorption, distribution, elimination of tea polyphenols in rats. | 1997 | Drug Metab. Dispos. | pmid:9311619 |
| Zhang A et al. | Inhibitory effects of jasmine green tea epicatechin isomers on free radical-induced lysis of red blood cells. | 1997 | Life Sci. | pmid:9244364 |
| Yoshiki Y et al. | Mechanism of catechin chemiluminescence in the presence of active oxygen. | 1996 May-Jun | J. Biolumin. Chemilumin. | pmid:8844343 |
| Sakanaka S et al. | Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium, Porphyromonas gingivalis. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8704303 |
| Kakuda T et al. | Effects of tea (Camellia sinensis) chemical compounds on ethanol metabolism in ICR mice. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8987593 |
| Yoshida T et al. | New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. | 1996 | Chem. Pharm. Bull. | pmid:8795264 |
| Shi ST et al. | Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice. | 1994 | Cancer Res. | pmid:8062257 |
| Du Q et al. | Purification of (-)-epigallocatechin from enzymatic hydrolysate of its gallate using high-speed counter-current chromatography. | 1994 | J Chromatogr A | pmid:7849987 |
| Matsuo T et al. | Identification of (+)-gallocatechin as a bio-antimutagenic compound in Psidium guava leaves. | 1994 | Phytochemistry | pmid:7765204 |
| Mahmood N et al. | Inhibition of HIV infection by flavanoids. | 1993 | Antiviral Res. | pmid:8279812 |
| Ikigai H et al. | Bactericidal catechins damage the lipid bilayer. | 1993 | Biochim. Biophys. Acta | pmid:8466924 |
| Isemura M et al. | Effects of catechins on the mouse lung carcinoma cell adhesion to the endothelial cells. | 1993 | Cell Biol. Int. | pmid:8348114 |
| Ikeda I et al. | Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats. | 1992 | Biochim. Biophys. Acta | pmid:1643098 |
| Taniguchi S et al. | Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. | 1992 | Cancer Lett. | pmid:1511409 |
| Wang ZY et al. | Inhibitory effect of green tea on the growth of established skin papillomas in mice. | 1992 | Cancer Res. | pmid:1423310 |
| Nakashima H et al. | Inhibition of human immunodeficiency viral replication by tannins and related compounds. | 1992 | Antiviral Res. | pmid:1416904 |
| Ebina T and Tsukada K | Protease inhibitors prevent the development of human rotavirus-induced diarrhea in suckling mice. | 1991 | Microbiol. Immunol. | pmid:1723785 |
| Chang WC and Hsu FL | Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946562 |
| Nakane H and Ono K | Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases. | 1990 | Biochemistry | pmid:1693287 |
| Ando T et al. | Effects of tea catechins on cholesterol absorption with exogenously hypercholesterolemic rat (ExHC-Ta). | 1989 | Bull Kanagawa Dent Coll | pmid:2519221 |
| Nakane H and Ono K | Differential inhibition of HIV-reverse transcriptase and various DNA and RNA polymerases by some catechin derivatives. | 1989 | Nucleic Acids Symp. Ser. | pmid:2481838 |
| Rizvi SI et al. | Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes. | Clin. Exp. Pharmacol. Physiol. | pmid:15730438 | |
| Guendez R et al. | An analytical survey of the polyphenols of seeds of varieties of grape (Vitis vinifera) cultivated in Greece: implications for exploitation as a source of value-added phytochemicals. | Phytochem Anal | pmid:15688951 | |
| Shen JZ et al. | Green tea catechins evoke a phasic contraction in rat aorta via H2O2-mediated multiple-signalling pathways. | Clin. Exp. Pharmacol. Physiol. | pmid:12542460 | |
| Goyal AK et al. | Effect of green tea mouth rinse on in plaque and saliva in children: An study. | J Indian Soc Pedod Prev Dent | pmid:28139481 | |
| Stanisavljević NS et al. | Identification of Phenolic Compounds from Seed Coats of Differently Colored European Varieties of Pea (Pisum sativum L.) and Characterization of Their Antioxidant and In Vitro Anticancer Activities. | Nutr Cancer | pmid:27348025 | |
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