(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Glei M et al. | Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cells. | 2003 Oct-Dec | Toxicol In Vitro | pmid:14599469 |
| Ludwig A et al. | The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15033450 |
| Hayakawa F et al. | Prooxidative activities of tea catechins in the presence of Cu2+. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15388955 |
| Sakanaka S and Okada Y | Inhibitory effects of green tea polyphenols on the production of a virulence factor of the periodontal-disease-causing anaerobic bacterium Porphyromonas gingivalis. | 2004 | J. Agric. Food Chem. | pmid:15030231 |
| Chu KO et al. | Determination of catechins and catechin gallates in tissues by liquid chromatography with coulometric array detection and selective solid phase extraction. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15380714 |
| Kodama S et al. | Direct enantioseparation of catechin and epicatechin in tea drinks by 6-O-alpha-D-glucosyl-beta-cyclodextrin-modified micellar electrokinetic chromatography. | 2004 | Electrophoresis | pmid:15352024 |
| Katsube T et al. | Screening for antioxidant activity in edible plant products: comparison of low-density lipoprotein oxidation assay, DPPH radical scavenging assay, and Folin-Ciocalteu assay. | 2004 | J. Agric. Food Chem. | pmid:15080652 |
| Kitagawa S et al. | Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells. | 2004 | J. Pharm. Pharmacol. | pmid:15285844 |
| Xu JZ et al. | Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. | 2004 | Br. J. Nutr. | pmid:15182391 |
| Takano K et al. | Inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. | 2004 | J. Agric. Food Chem. | pmid:15237969 |
| Koh SH et al. | Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals. | 2004 | Toxicology | pmid:15337584 |
| Yokozawa T and Nakagawa T | Inhibitory effects of Luobuma tea and its components against glucose-mediated protein damage. | 2004 | Food Chem. Toxicol. | pmid:15110107 |
| Ichiyanagi T et al. | Absorption and metabolism of delphinidin 3-O-beta-D-glucopyranoside in rats. | 2004 | Free Radic. Biol. Med. | pmid:15019977 |
| Jorgensen EM et al. | Analysis of the oxidative degradation of proanthocyanidins under basic conditions. | 2004 | J. Agric. Food Chem. | pmid:15080635 |
| Nakagawa T et al. | Activity of (-)-epigallocatechin 3-O-gallate against oxidative stress in rats with adenine-induced renal failure. | 2004 | J. Agric. Food Chem. | pmid:15053559 |
| Sugisawa A et al. | Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells. | 2004 | Mutat. Res. | pmid:15066578 |
| Sivakumaran S et al. | Floral procyanidins of the forage legume red clover (Trifolium pratense L.). | 2004 | J. Agric. Food Chem. | pmid:15030214 |
| Nakagawa H et al. | Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate. | 2004 | Carcinogenesis | pmid:15090467 |
| Arakawa H et al. | Role of hydrogen peroxide in bactericidal action of catechin. | 2004 | Biol. Pharm. Bull. | pmid:14993788 |
| Shui G and Peng LL | An improved method for the analysis of major antioxidants of Hibiscus esculentus Linn. | 2004 | J Chromatogr A | pmid:15453414 |