(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meydani M and Hasan ST | Dietary polyphenols and obesity. | 2010 | Nutrients | pmid:22254051 |
| Chu KO et al. | Green tea catechins and their oxidative protection in the rat eye. | 2010 | J. Agric. Food Chem. | pmid:20085274 |
| Kobayashi Y et al. | Advanced taste sensors based on artificial lipids with global selectivity to basic taste qualities and high correlation to sensory scores. | 2010 | Sensors (Basel) | pmid:22319306 |
| Korte G et al. | Tea catechins' affinity for human cannabinoid receptors. | 2010 | Phytomedicine | pmid:19897346 |
| Bengmark S et al. | Plant-derived health: the effects of turmeric and curcuminoids. | 2009 May-Jun | Nutr Hosp | pmid:19721899 |
| Wang YH et al. | Development of a whole-organism model to screen new compounds for sun protection. | 2009 May-Jun | Mar. Biotechnol. | pmid:19005726 |
| Ko CH et al. | Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. | 2009 | J. Agric. Food Chem. | pmid:19653629 |
| Gotti R et al. | Differentiation of green tea samples by chiral CD-MEKC analysis of catechins content. | 2009 | Electrophoresis | pmid:19637216 |
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| Nieman DC et al. | Effects of quercetin and EGCG on mitochondrial biogenesis and immunity. | 2009 | Med Sci Sports Exerc | pmid:19516153 |
| Larsen CA et al. | Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies. | 2009 | J. Med. Chem. | pmid:19839593 |
| Yasukawa K et al. | Anti-tumor promoters phenolics and triterpenoid from Hippophae rhamnoides. | 2009 | Fitoterapia | pmid:19535023 |
| Kuzuhara T et al. | Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase. | 2009 | PLoS Curr | pmid:20025206 |
| Shen CL et al. | Green tea polyphenols and Tai Chi for bone health: designing a placebo-controlled randomized trial. | 2009 | BMC Musculoskelet Disord | pmid:19732445 |
| Wang CT et al. | The effects of green tea (-)-epigallocatechin-3-gallate on reactive oxygen species in 3T3-L1 preadipocytes and adipocytes depend on the glutathione and 67 kDa laminin receptor pathways. | 2009 | Mol Nutr Food Res | pmid:19065584 |
| Sun Z et al. | Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. | 2009 | PLoS ONE | pmid:19668370 |
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| Yang CH et al. | Supplementary catechins attenuate cooking-oil-fumes-induced oxidative stress in rat lung. | 2009 | Chin J Physiol | pmid:19777801 |
| Rowe JA et al. | Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. | 2009 | Expert Rev Mol Med | pmid:19467172 |
| Otaki N et al. | Distribution and major sources of flavonoid intakes in the middle-aged Japanese women. | 2009 | J Clin Biochem Nutr | pmid:19430611 |
| Kell DB | Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. | 2009 | BMC Med Genomics | pmid:19133145 |
| Moran DM et al. | Puromycin-based vectors promote a ROS-dependent recruitment of PML to nuclear inclusions enriched with HSP70 and Proteasomes. | 2009 | BMC Cell Biol. | pmid:19409099 |
| Uysal UD et al. | Separation of catechins and methylxanthines in tea samples by capillary electrochromatography. | 2009 | J Sep Sci | pmid:19266552 |
| Söhle J et al. | White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes. | 2009 | Nutr Metab (Lond) | pmid:19409077 |
| Hegde ML et al. | Challenges associated with metal chelation therapy in Alzheimer's disease. | 2009 | J. Alzheimers Dis. | pmid:19363258 |
| Liu M et al. | Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma. | 2009 | Fitoterapia | pmid:19446614 |
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| Zhang YY et al. | Anti-proliferation Effect of Polypeptide Extracted from Scorpion Venom on Human Prostate Cancer Cells in vitro. | 2009 | J Clin Med Res | pmid:22505961 |
| Gregersen NT et al. | Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions. | 2009 | Br. J. Nutr. | pmid:19445822 |
| Lin BR et al. | Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling. | 2009 | J. Biomed. Sci. | pmid:19317920 |
| Singh AP et al. | Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin. | 2009 | Phytother Res | pmid:19172579 |
| Neyestani TR et al. | Selective effects of tea extract and its phenolic compounds on human peripheral blood mononuclear cell cytokine secretions. | 2009 | Int J Food Sci Nutr | pmid:18686109 |
| Schroeder EK et al. | Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. | 2009 | Antioxid. Redox Signal. | pmid:18754708 |
| Fisher-Wellman K and Bloomer RJ | Acute exercise and oxidative stress: a 30 year history. | 2009 | Dyn Med | pmid:19144121 |
| Ravindranath MH et al. | Differential growth suppression of human melanoma cells by tea (Camellia sinensis) epicatechins (ECG, EGC and EGCG). | 2009 | Evid Based Complement Alternat Med | pmid:18955299 |
| Kim TH et al. | Effects of (-) epigallocatechin-3-gallate on Na(+) currents in rat dorsal root ganglion neurons. | 2009 | Eur. J. Pharmacol. | pmid:19111536 |
| Bode AM and Dong Z | Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail. | 2009 | Cancer Prev Res (Phila) | pmid:19470792 |
| Sánchez-del-Campo L et al. | Binding of natural and synthetic polyphenols to human dihydrofolate reductase. | 2009 | Int J Mol Sci | pmid:20054477 |
| Shin SC and Choi JS | Effects of epigallocatechin gallate on the oral bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats. | 2009 | Anticancer Drugs | pmid:19491656 |
| Friedman M et al. | Stability of green tea catechins in commercial tea leaves during storage for 6 months. | 2009 | J. Food Sci. | pmid:19323750 |
| Hu B et al. | Efficient procedure for isolating methylated catechins from green tea and effective simultaneous analysis of ten catechins, three purine alkaloids, and gallic acid in tea by high-performance liquid chromatography with diode array detection. | 2009 | J Chromatogr A | pmid:19246045 |
| Zimmermann BF et al. | A shortcut from plasma to chromatographic analysis: straightforward and fast sample preparation for analysis of green tea catechins in human plasma. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19217834 |
| Robertson IM et al. | Solution structure of human cardiac troponin C in complex with the green tea polyphenol, (-)-epigallocatechin 3-gallate. | 2009 | J. Biol. Chem. | pmid:19542563 |
| Evensen NA and Braun PC | The effects of tea polyphenols on Candida albicans: inhibition of biofilm formation and proteasome inactivation. | 2009 | Can. J. Microbiol. | pmid:19898545 |
| Akagi T et al. | Expression balances of structural genes in shikimate and flavonoid biosynthesis cause a difference in proanthocyanidin accumulation in persimmon (Diospyros kaki Thunb.) fruit. | 2009 | Planta | pmid:19669159 |
| Oh HI et al. | The effect of xanthorrhizol on the expression of matrix metalloproteinase-1 and type-I procollagen in ultraviolet-irradiated human skin fibroblasts. | 2009 | Phytother Res | pmid:19277961 |
| Aihara Y et al. | Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19524436 |
| Yamabe N et al. | Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats. | 2009 | J Med Food | pmid:19735169 |
| Singh K et al. | Differential display mediated cloning of anthocyanidin reductase gene from tea (Camellia sinensis) and its relationship with the concentration of epicatechins. | 2009 | Tree Physiol. | pmid:19380395 |
| van't Slot G and Humpf HU | Degradation and metabolism of catechin, epigallocatechin-3-gallate (EGCG), and related compounds by the intestinal microbiota in the pig cecum model. | 2009 | J. Agric. Food Chem. | pmid:19670865 |
| Butt MS and Sultan MT | Green tea: nature's defense against malignancies. | 2009 | Crit Rev Food Sci Nutr | pmid:19399671 |
| Yamauchi R et al. | Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549. | 2009 | Toxicol In Vitro | pmid:19406223 |
| Cordero C et al. | Identification, quantitation, and method validation for flavan-3-ols in fermented ready-to-drink teas from the Italian market using HPLC-UV/DAD and LC-MS/MS. | 2009 | J Sep Sci | pmid:20029906 |
| Shin BC et al. | The protective effects of green tea extract against L-arginine toxicity to cultured human mesangial cells. | 2009 | J. Korean Med. Sci. | pmid:19194554 |
| Guedj F et al. | Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. | 2009 | PLoS ONE | pmid:19242551 |
| Al-Bloushi S et al. | Green tea modulates reserpine toxicity in animal models. | 2009 | J Toxicol Sci | pmid:19182437 |
| Hu J et al. | Preparation and antioxidant activity of green tea extract enriched in epigallocatechin (EGC) and epigallocatechin gallate (EGCG). | 2009 | J. Agric. Food Chem. | pmid:19182914 |
| Ku HC et al. | Green tea (-)-epigallocatechin gallate inhibits insulin stimulation of 3T3-L1 preadipocyte mitogenesis via the 67-kDa laminin receptor pathway. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19176763 |
| Stalmach A et al. | Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. | 2009 | Mol Nutr Food Res | pmid:18979506 |
| Jin SL et al. | Protective effect of epigallocatechin gallate on the immune function of dendritic cells after ultraviolet B irradiation. | 2009 | J Cosmet Dermatol | pmid:19735514 |
| Grace MH et al. | Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta. | 2009 | Nat Prod Commun | pmid:19768982 |
| Thomas F et al. | Dihydrotestosterone sensitises LNCaP cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor. | 2009 | Prostate | pmid:18942120 |
| Wei Y et al. | Separation of epigallocatechin and flavonoids from Hypericum perforatum L. by high-speed counter-current chromatography and preparative high-performance liquid chromatography. | 2009 | J Chromatogr A | pmid:19150073 |
| Chen Y et al. | Effect of girdling on levels of catechins in fresh leaf in relation to quality of 'Huang Zhi Xiang' Oolong' tea. | 2009 | Plant Foods Hum Nutr | pmid:19898938 |
| Ochiai H et al. | Epigallocatechin-3-gallate is an inhibitor of Na+, K(+)-ATPase by favoring the E1 conformation. | 2009 | Biochem. Pharmacol. | pmid:19539611 |
| Chen N et al. | Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. | 2009 | Nutr Res | pmid:19932867 |
| Han DH and Kim JH | Difference in growth suppression and apoptosis induction of EGCG and EGC on human promyelocytic leukemia HL-60 cells. | 2009 | Arch. Pharm. Res. | pmid:19407972 |
| Kushima Y et al. | Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line. | 2009 | Biol. Pharm. Bull. | pmid:19420761 |
| Severino JF et al. | Free radicals generated during oxidation of green tea polyphenols: electron paramagnetic resonance spectroscopy combined with density functional theory calculations. | 2009 | Free Radic. Biol. Med. | pmid:19439236 |
| Chang KC et al. | (-)Epigallocatechin-3-gallate inhibits the spontaneous firing of rat locus coeruleus neuron. | 2009 | Neurosci. Lett. | pmid:19383428 |
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| Zhang H et al. | Improving sensitivity by large-volume sample stacking combined with sweeping without polarity switching by capillary electrophoresis coupled to photodiode array ultraviolet detection. | 2008 | Electrophoresis | pmid:18384029 |
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| Chan CM et al. | Protective effects of (-)-epigallocatechin gallate on UVA-induced damage in ARPE19 cells. | 2008 | Mol. Vis. | pmid:19119326 |
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| Haque AM et al. | Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats. | 2008 | J. Nutr. Biochem. | pmid:18280729 |
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| Son YH et al. | Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209571 |
| Zhu BT et al. | Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (-)-epigallocatechin-3-O-gallate. | 2008 | Xenobiotica | pmid:18197555 |
| Mukai D et al. | Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans. | 2008 | J Nat Med | pmid:18404315 |
| Jin YR et al. | Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209568 |
| Li C and Choi JS | Effects of epigallocatechin gallate on the bioavailability and pharmacokinetics of diltiazem in rats. | 2008 | Pharmazie | pmid:19069242 |
| Scandlyn MJ et al. | A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate. | 2008 | Br. J. Cancer | pmid:18797454 |