(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Masukawa Y et al. | Determination of green tea catechins in human plasma using liquid chromatography-electrospray ionization mass spectrometry. | 2006 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16513433 |
| Gagné S et al. | Composition and cellular localization of tannins in Cabernet Sauvignon skins during growth. | 2006 | J. Agric. Food Chem. | pmid:17147434 |
| Boyé-Harnasch M and Cullin C | A novel in vitro filter trap assay identifies tannic acid as an amyloid aggregation inducer for HET-s. | 2006 | J. Biotechnol. | pmid:16621084 |
| Lin SC et al. | The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells. | 2006 | Cancer Lett. | pmid:15975707 |
| Luo H et al. | Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. | 2006 | Carcinogenesis | pmid:15930028 |
| Stapleton PD et al. | Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacillin by nongalloylated catechins. | 2006 | Antimicrob. Agents Chemother. | pmid:16436737 |
| Wolfram S et al. | Anti-obesity effects of green tea: from bedside to bench. | 2006 | Mol Nutr Food Res | pmid:16470636 |
| Marcondes S et al. | Cyclic GMP-independent mechanisms contribute to the inhibition of platelet adhesion by nitric oxide donor: a role for alpha-actinin nitration. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16492779 |
| Luximon-Ramma A et al. | Assessment of the polyphenolic composition of the organic extracts of Mauritian black teas: a potential contributor to their antioxidant functions. | 2006 | Biofactors | pmid:17012766 |
| Ko CH et al. | Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-deficient erythrocytes in vitro. | 2006 | Int. J. Mol. Med. | pmid:17016632 |
| Jin UH et al. | Inhibitory effect of Salvia miltiorrhia BGE on matrix metalloproteinase-9 activity and migration of TNF-alpha-induced human aortic smooth muscle cells. | 2006 | Vascul. Pharmacol. | pmid:16540379 |
| Haque AM et al. | Long-term administration of green tea catechins improves spatial cognition learning ability in rats. | 2006 | J. Nutr. | pmid:16549472 |
| Macz-Pop GA et al. | New flavanol-anthocyanin condensed pigments and anthocyanin composition in guatemalan beans (Phaseolus spp.). | 2006 | J. Agric. Food Chem. | pmid:16417317 |
| Han KH et al. | A water extract of Artemisia capillaris prevents 2,2'-azobis(2-amidinopropane) dihydrochloride-induced liver damage in rats. | 2006 | J Med Food | pmid:17004896 |
| John KM et al. | Electrofocusing of methanolic extracts for identification of individual flavonol biomolecules in Camellia species. | 2006 | J. Agric. Food Chem. | pmid:16608196 |
| Ayoub S and Melzig MF | Induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green tea. | 2006 | J. Pharm. Pharmacol. | pmid:16597367 |
| Xu J et al. | Mixed-mode retention mechanism for (-)-epigallocatechin gallate on a 12% cross-linked agarose gel media. | 2006 | J Chromatogr A | pmid:17049539 |
| Nishioka H et al. | Comparative efficacy of oligonol, catechin and (-)-epigallocatechin 3-O-gallate in modulating the potassium bromate-induced renal toxicity in rats. | 2006 | Toxicology | pmid:16916569 |
| Sen P et al. | Tea polyphenol epigallocatechin 3-gallate impedes the anti-apoptotic effects of low-grade repetitive stress through inhibition of Akt and NFkappaB survival pathways. | 2006 | FEBS Lett. | pmid:16376342 |
| Kweon MH et al. | Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate. | 2006 | J. Biol. Chem. | pmid:16950787 |
| Pajonk F et al. | The effects of tea extracts on proinflammatory signaling. | 2006 | BMC Med | pmid:17140430 |
| Park YJ et al. | [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. | 2006 | Yonsei Med. J. | pmid:17066513 |
| Das A et al. | Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids. | 2006 | Int. J. Cancer | pmid:16988947 |
| Eto I | "Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells". | 2006 | Cancer Cell Int. | pmid:16899133 |
| Jin Y et al. | Separation of catechin compounds from different teas. | 2006 | Biotechnol J | pmid:16892250 |
| Lang R et al. | Development of a stable isotope dilution analysis with liquid chromatography-tandem mass spectrometry detection for the quantitative analysis of di- and trihydroxybenzenes in foods and model systems. | 2006 | J. Agric. Food Chem. | pmid:16881674 |
| Meagher LP et al. | Floral Trifolium proanthocyanidins: polyphenol formation and compositional diversity. | 2006 | J. Agric. Food Chem. | pmid:16848535 |
| Lo CY et al. | Trapping reactions of reactive carbonyl species with tea polyphenols in simulated physiological conditions. | 2006 | Mol Nutr Food Res | pmid:17103374 |
| Nakazono M et al. | The chemiluminescence mechanism of 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione, and the characteristics of chemiluminescence developed in the reaction with CH(3)CNH(2)O(2)NaOH. | 2006 | Talanta | pmid:18970740 |
| Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
| Tasdemir D et al. | Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | 2006 | J. Med. Chem. | pmid:16722653 |
| Yousef GG et al. | Comparative phytochemical characterization of three Rhodiola species. | 2006 | Phytochemistry | pmid:16956631 |
| Sivakumaran S et al. | Variation of proanthocyanidins in Lotus species. | 2006 | J. Chem. Ecol. | pmid:16900433 |
| Park BJ et al. | Antifungal susceptibility of epigallocatechin 3-O-gallate (EGCg) on clinical isolates of pathogenic yeasts. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16831406 |
| Wang S et al. | Green tea catechins inhibit pancreatic phospholipase A(2) and intestinal absorption of lipids in ovariectomized rats. | 2006 | J. Nutr. Biochem. | pmid:16713229 |
| Seeram NP et al. | Catechin and caffeine content of green tea dietary supplements and correlation with antioxidant capacity. | 2006 | J. Agric. Food Chem. | pmid:16506807 |
| Hirasawa M et al. | Inhibition of acid production in dental plaque bacteria by green tea catechins. | 2006 | Caries Res. | pmid:16707877 |
| Hisamura F et al. | Protective effect of green tea extract and tea polyphenols against FK506-induced cytotoxicity in renal cells. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16445594 |
| Cortell JM and Kennedy JA | Effect of shading on accumulation of flavonoid compounds in (Vitis vinifera L.) pinot noir fruit and extraction in a model system. | 2006 | J. Agric. Food Chem. | pmid:17061828 |
| Oben J et al. | The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. | 2006 | Lipids Health Dis | pmid:16948861 |
| Naka T et al. | Modulation of branching morphogenesis of fetal mouse submandibular gland by sodium ascorbate and epigallocatechin gallate. | 2005 Sep-Oct | In Vivo | pmid:16097443 |
| Gyémánt N et al. | In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. | 2005 Mar-Apr | In Vivo | pmid:15796199 |
| Lyu SY and Park WB | Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. | 2005 | Arch. Pharm. Res. | pmid:15974445 |
| Mukai K et al. | Structure-activity relationship of the tocopherol-regeneration reaction by catechins. | 2005 | Free Radic. Biol. Med. | pmid:15808422 |
| Proctor GB et al. | Salivary proteins interact with dietary constituents to modulate tooth staining. | 2005 | J. Dent. Res. | pmid:15615880 |
| Navarro RE et al. | Complexation of epigallocatechin gallate (a green tea extract, egcg) with Mn2+: nuclear spin relaxation by the paramagnetic ion. | 2005 | J. Inorg. Biochem. | pmid:15621293 |
| Mizushina Y et al. | Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15950188 |
| Ozcan A et al. | Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced cystitis in rats. | 2005 | Arch. Toxicol. | pmid:15800758 |
| Yao L et al. | Seasonal variations of phenolic compounds in Australia-grown tea (Camellia sinensis). | 2005 | J. Agric. Food Chem. | pmid:16076137 |
| Kumar NS and Rajapaksha M | Separation of catechin constituents from five tea cultivars using high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:16078712 |
| Nakai M et al. | Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. | 2005 | J. Agric. Food Chem. | pmid:15913331 |
| Herrero M et al. | Pressurized liquid extraction-capillary electrophoresis-mass spectrometry for the analysis of polar antioxidants in rosemary extracts. | 2005 | J Chromatogr A | pmid:16114236 |
| Suzuki Y et al. | Dose-dependent suppression of tea catechins with a galloyl moiety on postprandial hypertriglyceridemia in rats. | 2005 | Biosci. Biotechnol. Biochem. | pmid:16041132 |
| Hayashi N et al. | Reduction of catechin astringency by the complexation of gallate-type catechins with pectin. | 2005 | Biosci. Biotechnol. Biochem. | pmid:16041135 |
| Mukai K et al. | Kinetic study of the quenching reaction of singlet oxygen by tea catechins in ethanol solution. | 2005 | Free Radic. Biol. Med. | pmid:16109305 |
| Yang C et al. | Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. | 2005 | Toxicology | pmid:16085347 |
| Ikeda I et al. | Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats. | 2005 | J. Nutr. | pmid:15671206 |
| Babich H et al. | Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity. | 2005 | Toxicol In Vitro | pmid:15649637 |
| Chen D et al. | Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. | 2005 | Biochem. Pharmacol. | pmid:15857617 |
| Yoon JH and Baek SJ | Molecular targets of dietary polyphenols with anti-inflammatory properties. | 2005 | Yonsei Med. J. | pmid:16259055 |
| Nakamuta M et al. | Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells. | 2005 | Int. J. Mol. Med. | pmid:16142404 |
| Hung PF et al. | Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15647388 |
| Arendt BM et al. | Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). | 2005 | Nutr J | pmid:16287499 |
| Chow HH et al. | Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. | 2005 | Clin. Cancer Res. | pmid:15958649 |
| Huang HY and Lien WC | Analyses of phenolic compounds by microemulsion electrokinetic chromatography. | 2005 | Electrophoresis | pmid:16041702 |
| Anger DL et al. | Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols. | 2005 | Br. J. Pharmacol. | pmid:15895106 |
| Baek WK et al. | Inhibitory modulation of ATP-sensitive potassium channels by gallate-ester moiety of (-)-epigallocatechin-3-gallate. | 2005 | Biochem. Pharmacol. | pmid:16216226 |
| Backleh-Sohrt M et al. | Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials. | 2005 | J. Nat. Prod. | pmid:16180819 |
| Zhou ZH et al. | Puerins A and B, two new 8-C substituted flavan-3-ols from Pu-er tea. | 2005 | J. Agric. Food Chem. | pmid:16248561 |
| Cortell JM et al. | Influence of vine vigor on grape (Vitis vinifera L. Cv. Pinot Noir) and wine proanthocyanidins. | 2005 | J. Agric. Food Chem. | pmid:15998151 |
| Mazauric JP and Salmon JM | Interactions between yeast lees and wine polyphenols during simulation of wine aging: I. Analysis of remnant polyphenolic compounds in the resulting wines. | 2005 | J. Agric. Food Chem. | pmid:15998128 |
| Netsch MI et al. | Inhibitory activity of a green tea extract and some of its constituents on multidrug resistance-associated protein 2 functionality. | 2005 | Planta Med. | pmid:15729621 |
| Lee YK et al. | VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance. | 2005 | Leukemia | pmid:15703780 |
| Zhou B et al. | Evidence for alpha-tocopherol regeneration reaction of green tea polyphenols in SDS micelles. | 2005 | Free Radic. Biol. Med. | pmid:15589374 |
| Vovk I et al. | Separation of eight selected flavan-3-ols on cellulose thin-layer chromatographic plates. | 2005 | J Chromatogr A | pmid:16001555 |
| Di Paola R et al. | Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. | 2005 | Respir. Res. | pmid:15987519 |
| Lambert JD et al. | Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15686878 |
| Punyasiri PA et al. | Preformed and induced chemical resistance of tea leaf against Exobasidium vexans infection. | 2005 | J. Chem. Ecol. | pmid:16222773 |
| McDougall GJ et al. | Anthocyanin-flavanol condensation products from black currant (Ribes nigrum L.). | 2005 | J. Agric. Food Chem. | pmid:16190645 |
| Feucht W et al. | Flavanols in somatic cell division and male meiosis of tea (Camellia sinensis) anthers. | 2005 | Plant Biol (Stuttg) | pmid:15822012 |
| Tanaka T et al. | Regioselectivity in benzotropolone formation between catechins and proanthocyanidins. | 2005 | Nat. Prod. Res. | pmid:16320425 |
| Agusta A et al. | Stereoselective oxidation at C-4 of flavans by the endophytic fungus Diaporthe sp. isolated from a tea plant. | 2005 | Chem. Pharm. Bull. | pmid:16327190 |
| Kawai K | Comment on inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. | 2005 | J. Agric. Food Chem. | pmid:15713057 |
| Doss MX et al. | Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases. | 2005 | J. Nutr. Biochem. | pmid:15866224 |
| Kim M et al. | (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. | 2005 | Carcinogenesis | pmid:15860507 |
| Song JM et al. | Antiviral effect of catechins in green tea on influenza virus. | 2005 | Antiviral Res. | pmid:16137775 |
| Aneja R et al. | Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. | 2004 Jan-Jun | Mol. Med. | pmid:15502883 |
| Zhang L et al. | Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. | 2004 | Int J Pharm | pmid:15541906 |
| Koyama Y et al. | Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo. | 2004 | Planta Med. | pmid:15549673 |
| Apak R et al. | Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. | 2004 | J. Agric. Food Chem. | pmid:15612784 |
| Wang R and Zhou W | Stability of tea catechins in the breadmaking process. | 2004 | J. Agric. Food Chem. | pmid:15612821 |
| Jeong JH et al. | Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine. | 2004 | Toxicology | pmid:14698567 |
| Punyasiri PA et al. | Flavonoid biosynthesis in the tea plant Camellia sinensis: properties of enzymes of the prominent epicatechin and catechin pathways. | 2004 | Arch. Biochem. Biophys. | pmid:15464723 |
| Chisholm K et al. | Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells. | 2004 | Anticancer Drugs | pmid:15457130 |
| Kim DO and Lee CY | Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. | 2004 | Crit Rev Food Sci Nutr | pmid:15462129 |
| Le Gall G et al. | Metabolite profiling using (1)H NMR spectroscopy for quality assessment of green tea, Camellia sinensis (L.). | 2004 | J. Agric. Food Chem. | pmid:14969518 |
| Kuo YC et al. | Isolation and immunomodulatory effect of flavonoids from Syzygium samarangense. | 2004 | Planta Med. | pmid:15643565 |
| Nimal Punyasiri PA et al. | Exobasidium vexans infection of Camellia sinensis increased 2,3-cis isomerisation and gallate esterification of proanthocyanidins. | 2004 | Phytochemistry | pmid:15504433 |
| Okamoto M et al. | Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis. | 2004 | Oral Microbiol. Immunol. | pmid:14871352 |
| Zheng Y et al. | Inhibitory effect of epigallocatechin 3-O-gallate on vascular smooth muscle cell hypertrophy induced by angiotensin II. | 2004 | J. Cardiovasc. Pharmacol. | pmid:14716206 |