(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Seeram NP et al. | Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. | 2003 | Nutr Cancer | pmid:12925310 |
| Yeh CW et al. | Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. | 2003 | Pharmacogenomics J. | pmid:12931129 |
| Bellosta S et al. | Inhibition of metalloproteinase-9 activity and gene expression by polyphenolic compounds isolated from the bark of Tristaniopsis calobuxus (Myrtaceae). | 2003 | Cell. Mol. Life Sci. | pmid:12943230 |
| Oku N et al. | Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP. | 2003 | Biol. Pharm. Bull. | pmid:12951464 |
| Roginsky V et al. | Chain-breaking antioxidant activity and cyclic voltammetry characterization of polyphenols in a range of green, oolong, and black teas. | 2003 | J. Agric. Food Chem. | pmid:12952436 |
| Chow HH et al. | Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. | 2003 | Clin. Cancer Res. | pmid:12960117 |
| RamÃrez-Mares MV and de MejÃa EG | Comparative study of the antioxidant effect of ardisin and epigallocatechin gallate in rat hepatocytes exposed to benomyl and 1-nitropyrene. | 2003 | Food Chem. Toxicol. | pmid:12963005 |
| Naftalin RJ et al. | Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1. | 2003 | Br. J. Pharmacol. | pmid:12970085 |
| Corsino J et al. | Antioxidant flavan-3-ols and flavonol glycosides from Maytenus aquifolium. | 2003 | Phytother Res | pmid:13680823 |
| Nakashima H et al. | Inhibition of human immunodeficiency viral replication by tannins and related compounds. | 1992 | Antiviral Res. | pmid:1416904 |
| Wang ZY et al. | Inhibitory effect of green tea on the growth of established skin papillomas in mice. | 1992 | Cancer Res. | pmid:1423310 |
| Morikawa T et al. | Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. | 2003 | J. Nat. Prod. | pmid:14510595 |
| Maranz S et al. | Phenolic constituents of shea (Vitellaria paradoxa) kernels. | 2003 | J. Agric. Food Chem. | pmid:14518954 |
| Yoshimura Y et al. | Evaluation of the NO scavenging activity of procyanidin in grape seed by use of the TMA-PTIO/NOC 7 ESR system. | 2003 | J. Agric. Food Chem. | pmid:14558755 |
| Koh SH et al. | Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3. | 2003 | Brain Res. Mol. Brain Res. | pmid:14559356 |
| Jeon SY et al. | Green tea catechins as a BACE1 (beta-secretase) inhibitor. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592472 |
| Glei M et al. | Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cells. | 2003 Oct-Dec | Toxicol In Vitro | pmid:14599469 |
| Kumagai A et al. | Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins. | 2003 | Bioorg. Med. Chem. | pmid:14604677 |
| Kundu JK et al. | Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells. | 2003 | J. Nutr. | pmid:14608118 |
| Molan AL et al. | Effect of flavan-3-ols on in vitro egg hatching, larval development and viability of infective larvae of Trichostrongylus colubriformis. | 2003 | Int. J. Parasitol. | pmid:14636684 |