(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Vergote D et al. | (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. | 2002 | Breast Cancer Res. Treat. | pmid:12462380 |
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| Chow HH et al. | Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. | 2001 | Cancer Epidemiol. Biomarkers Prev. | pmid:11205489 |
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| Taniguchi S et al. | Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. | 1992 | Cancer Lett. | pmid:1511409 |
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| Kennedy DO et al. | Cellular thiol status-dependent inhibition of tumor cell growth via modulation of retinoblastoma protein phosphorylation by (-)-epigallocatechin. | 2002 | Cancer Lett. | pmid:11880178 |
| Lee MH et al. | EBV DNA polymerase inhibition of tannins from Eugenia uniflora. | 2000 | Cancer Lett. | pmid:10806300 |
| Kuzuhara T et al. | Green tea catechin as a chemical chaperone in cancer prevention. | 2008 | Cancer Lett. | pmid:18068893 |
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| Bode AM and Dong Z | Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail. | 2009 | Cancer Prev Res (Phila) | pmid:19470792 |