(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Del Rio D et al. | Bioavailability and catabolism of green tea flavan-3-ols in humans. | 2010 Nov-Dec | Nutrition | pmid:20080030 |
| Del Rio D et al. | Bioavailability of catechins from ready-to-drink tea. | 2010 | Nutrition | pmid:19765952 |
| Meydani M and Hasan ST | Dietary polyphenols and obesity. | 2010 | Nutrients | pmid:22254051 |
| Scola G et al. | Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity. | 2010 | Nutrients | pmid:22253995 |
| Yu SY et al. | Phenolic composition, antioxidant activity and anti-adipogenic effect of hot water extract from safflower (Carthamus tinctorius L.) seed. | 2013 | Nutrients | pmid:24288028 |
| Kang SN et al. | In vitro anti-osteoporosis properties of diverse Korean Drynariae rhizoma phenolic extracts. | 2014 | Nutrients | pmid:24763116 |
| Mannion C et al. | Components of an anticancer diet: dietary recommendations, restrictions and supplements of the Bill Henderson Protocol. | 2011 | Nutrients | pmid:22254073 |
| Lee JB et al. | The effect of Oligonol intake on cortisol and related cytokines in healthy young men. | 2010 | Nutr Res Pract | pmid:20607065 |
| Park MY et al. | Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin. | 2008 | Nutr Res Pract | pmid:20126360 |
| Yang YJ et al. | Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults. | 2012 | Nutr Res Pract | pmid:22413043 |
| Choi SK et al. | Suppression of oxidative stress by grape seed supplementation in rats. | 2012 | Nutr Res Pract | pmid:22413034 |
| Sung JH et al. | The anti-obesity effect of Lethariella cladonioides in 3T3-L1 cells and obese mice. | 2011 | Nutr Res Pract | pmid:22259674 |
| Neilson AP et al. | Tea catechin auto-oxidation dimers are accumulated and retained by Caco-2 human intestinal cells. | 2010 | Nutr Res | pmid:20579525 |
| Takechi R et al. | Elevated plasma and urinary concentrations of green tea catechins associated with improved plasma lipid profile in healthy Japanese women. | 2016 | Nutr Res | pmid:26923508 |
| Chen N et al. | Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. | 2009 | Nutr Res | pmid:19932867 |
| Kelsey N et al. | Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress. | 2011 | Nutr Neurosci | pmid:22053756 |
| Nunn AV et al. | Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle. | 2010 | Nutr Metab (Lond) | pmid:21143891 |
| Söhle J et al. | White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes. | 2009 | Nutr Metab (Lond) | pmid:19409077 |
| Moon HS et al. | Physico-chemical modifications of conjugated linoleic acid for ruminal protection and oxidative stability. | 2008 | Nutr Metab (Lond) | pmid:18513443 |
| Ortsäter H et al. | Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. | 2012 | Nutr Metab (Lond) | pmid:22333133 |
| Josic J et al. | Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial. | 2010 | Nutr J | pmid:21118565 |
| Carlsen MH et al. | The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. | 2010 | Nutr J | pmid:20096093 |
| Arendt BM et al. | Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). | 2005 | Nutr J | pmid:16287499 |
| Bengmark S et al. | Plant-derived health: the effects of turmeric and curcuminoids. | 2009 May-Jun | Nutr Hosp | pmid:19721899 |
| Vázquez Cisneros LC et al. | Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review | 2017 | Nutr Hosp | pmid:28627214 |
| Bhatia N et al. | Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. | 2001 | Nutr Cancer | pmid:11759294 |
| Sartippour MR et al. | Green tea and its catechins inhibit breast cancer xenografts. | 2001 | Nutr Cancer | pmid:11962250 |
| Saleem M et al. | Tea beverage in chemoprevention of prostate cancer: a mini-review. | 2003 | Nutr Cancer | pmid:14769533 |
| Stanisavljević NS et al. | Identification of Phenolic Compounds from Seed Coats of Differently Colored European Varieties of Pea (Pisum sativum L.) and Characterization of Their Antioxidant and In Vitro Anticancer Activities. | Nutr Cancer | pmid:27348025 | |
| Tang FY and Meydani M | Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production. | 2001 | Nutr Cancer | pmid:12094614 |
| Facchini A et al. | Effect of green tea extract on the induction of ornithine decarboxylase and the activation of extracellular signal-regulated kinase in bladder carcinoma ECV304 cells. | 2003 | Nutr Cancer | pmid:14769544 |
| Seeram NP et al. | Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. | 2003 | Nutr Cancer | pmid:12925310 |
| Nakane H and Ono K | Differential inhibition of HIV-reverse transcriptase and various DNA and RNA polymerases by some catechin derivatives. | 1989 | Nucleic Acids Symp. Ser. | pmid:2481838 |
| Choi JY et al. | Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate. | 2002 | Neurotoxicology | pmid:12387363 |
| Chang KC et al. | (-)Epigallocatechin-3-gallate inhibits the spontaneous firing of rat locus coeruleus neuron. | 2009 | Neurosci. Lett. | pmid:19383428 |
| Jimenez-Del-Rio M et al. | The effects of polyphenols on survival and locomotor activity in Drosophila melanogaster exposed to iron and paraquat. | 2010 | Neurochem. Res. | pmid:19701790 |
| Pan CY et al. | Enhancement of inward Ca(2+) currents in bovine chromaffin cells by green tea polyphenol extracts. | 2002 | Neurochem. Int. | pmid:11738479 |
| Cox CJ et al. | Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. | 2015 | Neurobiol. Aging | pmid:25316600 |
| Paterniti I et al. | Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19337722 |
| Anke J et al. | Procyanidins from Myrothamnus flabellifolia. | 2008 | Nat. Prod. Res. | pmid:18932087 |
| Tanaka T et al. | Regioselectivity in benzotropolone formation between catechins and proanthocyanidins. | 2005 | Nat. Prod. Res. | pmid:16320425 |
| Roberts BE et al. | A synergistic small-molecule combination directly eradicates diverse prion strain structures. | 2009 | Nat. Chem. Biol. | pmid:19915541 |
| Grace MH et al. | Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta. | 2009 | Nat Prod Commun | pmid:19768982 |
| Neukam K et al. | Tea flavanols inhibit cell growth and DNA topoisomerase II activity and induce endoreduplication in cultured Chinese hamster cells. | 2008 | Mutat. Res. | pmid:18541453 |
| Krul C et al. | Antimutagenic activity of green tea and black tea extracts studied in a dynamic in vitro gastrointestinal model. | 2001 | Mutat. Res. | pmid:11239964 |
| Dhawan A et al. | Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. | 2002 | Mutat. Res. | pmid:11909753 |
| Yonezawa Y et al. | Mut-Test to detect substances suppressing spontaneous mutation due to oxidative damage. | 2001 | Mutat. Res. | pmid:11152968 |
| Sugisawa A et al. | Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells. | 2004 | Mutat. Res. | pmid:15066578 |
| Muto S et al. | Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450. | 2001 | Mutat. Res. | pmid:11470492 |
| Mitsuhashi S et al. | Pyrogallol structure in polyphenols is involved in apoptosis-induction on HEK293T and K562 cells. | 2008 | Molecules | pmid:19052524 |