(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Ludwig A et al. | The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15033450 |
| Nakagawa T et al. | Activity of (-)-epigallocatechin 3-O-gallate against oxidative stress in rats with adenine-induced renal failure. | 2004 | J. Agric. Food Chem. | pmid:15053559 |
| Sugisawa A et al. | Anti-genotoxic effects of tea catechins against reactive oxygen species in human lymphoblastoid cells. | 2004 | Mutat. Res. | pmid:15066578 |
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| Nakagawa H et al. | Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate. | 2004 | Carcinogenesis | pmid:15090467 |
| Yokozawa T and Nakagawa T | Inhibitory effects of Luobuma tea and its components against glucose-mediated protein damage. | 2004 | Food Chem. Toxicol. | pmid:15110107 |
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| Merghem R et al. | Qualitative analysis and HPLC isolation and identification of procyanidins from Vicia faba. | Phytochem Anal | pmid:15116939 | |
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| Xu JZ et al. | Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. | 2004 | Br. J. Nutr. | pmid:15182391 |
| Watson JL et al. | Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15231486 |
| Takano K et al. | Inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. | 2004 | J. Agric. Food Chem. | pmid:15237969 |
| Kitagawa S et al. | Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells. | 2004 | J. Pharm. Pharmacol. | pmid:15285844 |
| Tsuneki H et al. | Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. | 2004 | BMC Pharmacol. | pmid:15331020 |
| Koh SH et al. | Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals. | 2004 | Toxicology | pmid:15337584 |
| Kodama S et al. | Direct enantioseparation of catechin and epicatechin in tea drinks by 6-O-alpha-D-glucosyl-beta-cyclodextrin-modified micellar electrokinetic chromatography. | 2004 | Electrophoresis | pmid:15352024 |
| Chu KO et al. | Determination of catechins and catechin gallates in tissues by liquid chromatography with coulometric array detection and selective solid phase extraction. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15380714 |
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| Shui G and Peng LL | An improved method for the analysis of major antioxidants of Hibiscus esculentus Linn. | 2004 | J Chromatogr A | pmid:15453414 |
| Chisholm K et al. | Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells. | 2004 | Anticancer Drugs | pmid:15457130 |
| Kim DO and Lee CY | Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. | 2004 | Crit Rev Food Sci Nutr | pmid:15462129 |
| Punyasiri PA et al. | Flavonoid biosynthesis in the tea plant Camellia sinensis: properties of enzymes of the prominent epicatechin and catechin pathways. | 2004 | Arch. Biochem. Biophys. | pmid:15464723 |
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