(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pan CY et al. | Enhancement of inward Ca(2+) currents in bovine chromaffin cells by green tea polyphenol extracts. | 2002 | Neurochem. Int. | pmid:11738479 |
| Anderson RA and Polansky MM | Tea enhances insulin activity. | 2002 | J. Agric. Food Chem. | pmid:12428980 |
| Tan X et al. | Changes in ceramide levels upon catechins-induced apoptosis in LoVo cells. | 2002 | Life Sci. | pmid:12148694 |
| Sarni-Manchado P and Cheynier V | Study of non-covalent complexation between catechin derivatives and peptides by electrospray ionization mass spectrometry. | 2002 | J Mass Spectrom | pmid:12112743 |
| de MejÃa EG and RamÃrez-Mares MV | Leaf extract from Ardisia compressa protects against 1-nitropyrene-induced cytotoxicity and its antioxidant defense disruption in cultured rat hepatocytes. | 2002 | Toxicology | pmid:12204551 |
| Tanaka T et al. | Accumulation of epigallocatechin quinone dimers during tea fermentation and formation of theasinensins. | 2002 | J. Nat. Prod. | pmid:12444680 |
| Pomponio R et al. | Microemulsion electrokinetic chromatography for the analysis of green tea catechins: effect of the cosurfactant on the separation selectivity. | 2003 | Electrophoresis | pmid:12761797 |
| Mizooku Y et al. | Analysis of oxidized epigallocatechin gallate by liquid chromatography/mass spectrometry. | 2003 | Rapid Commun. Mass Spectrom. | pmid:12876693 |
| Maranz S et al. | Phenolic constituents of shea (Vitellaria paradoxa) kernels. | 2003 | J. Agric. Food Chem. | pmid:14518954 |
| Mun'im A et al. | Antioxidative compounds from Crotalaria sessiliflora. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729010 |
| Behrens A et al. | MALDI-TOF mass spectrometry and PSD fragmentation as means for the analysis of condensed tannins in plant leaves and needles. | 2003 | Phytochemistry | pmid:12591272 |
| Ikeda I et al. | Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate. | 2003 | J. Agric. Food Chem. | pmid:14640575 |
| Lin YS et al. | Determination of tea polyphenols and caffeine in tea flowers (Camellia sinensis) and their hydroxyl radical scavenging and nitric oxide suppressing effects. | 2003 | J. Agric. Food Chem. | pmid:12568558 |
| Dauer A et al. | Polymeric proanthocyanidins from the bark of Hamamelis virginiana. | 2003 | Planta Med. | pmid:12567291 |
| Naftalin RJ et al. | Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1. | 2003 | Br. J. Pharmacol. | pmid:12970085 |
| Oku N et al. | Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP. | 2003 | Biol. Pharm. Bull. | pmid:12951464 |
| Malik A et al. | DNA degradation by water extract of green tea in the presence of copper ions: implications for anticancer properties. | 2003 | Phytother Res | pmid:12722140 |
| Chow HH et al. | Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. | 2003 | Clin. Cancer Res. | pmid:12960117 |
| Maeda K et al. | Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier. | 2003 | Atherosclerosis | pmid:12482547 |
| Lu H et al. | Glucuronides of tea catechins: enzymology of biosynthesis and biological activities. | 2003 | Drug Metab. Dispos. | pmid:12642472 |
| Zhang N et al. | An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice. | 2003 | J. Immunol. | pmid:12794164 |
| Roginsky V | Chain-breaking antioxidant activity of natural polyphenols as determined during the chain oxidation of methyl linoleate in Triton X-100 micelles. | 2003 | Arch. Biochem. Biophys. | pmid:12781778 |
| Hagerman AE et al. | Radical chemistry of epigallocatechin gallate and its relevance to protein damage. | 2003 | Arch. Biochem. Biophys. | pmid:12745262 |
| Lu H et al. | Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate. | 2003 | Drug Metab. Dispos. | pmid:12695345 |
| Levine L | Does the release of arachidonic acid from cells play a role in cancer chemoprevention? | 2003 | FASEB J. | pmid:12724337 |
| Cabrera C et al. | Determination of tea components with antioxidant activity. | 2003 | J. Agric. Food Chem. | pmid:12848521 |
| Saleem M et al. | Tea beverage in chemoprevention of prostate cancer: a mini-review. | 2003 | Nutr Cancer | pmid:14769533 |
| Palermo CM et al. | Identification of potential aryl hydrocarbon receptor antagonists in green tea. | 2003 | Chem. Res. Toxicol. | pmid:12870889 |
| Molan AL et al. | Effect of flavan-3-ols on in vitro egg hatching, larval development and viability of infective larvae of Trichostrongylus colubriformis. | 2003 | Int. J. Parasitol. | pmid:14636684 |
| Corsino J et al. | Antioxidant flavan-3-ols and flavonol glycosides from Maytenus aquifolium. | 2003 | Phytother Res | pmid:13680823 |
| Roginsky V et al. | Chain-breaking antioxidant activity and cyclic voltammetry characterization of polyphenols in a range of green, oolong, and black teas. | 2003 | J. Agric. Food Chem. | pmid:12952436 |
| Bellosta S et al. | Inhibition of metalloproteinase-9 activity and gene expression by polyphenolic compounds isolated from the bark of Tristaniopsis calobuxus (Myrtaceae). | 2003 | Cell. Mol. Life Sci. | pmid:12943230 |
| Yeh CW et al. | Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. | 2003 | Pharmacogenomics J. | pmid:12931129 |
| Facchini A et al. | Effect of green tea extract on the induction of ornithine decarboxylase and the activation of extracellular signal-regulated kinase in bladder carcinoma ECV304 cells. | 2003 | Nutr Cancer | pmid:14769544 |
| Lin YS et al. | Factors affecting the levels of tea polyphenols and caffeine in tea leaves. | 2003 | J. Agric. Food Chem. | pmid:12643643 |
| Lill G et al. | Complex effects of different green tea catechins on human platelets. | 2003 | FEBS Lett. | pmid:12832052 |
| Jeon SY et al. | Green tea catechins as a BACE1 (beta-secretase) inhibitor. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14592472 |
| Yoshimura Y et al. | Evaluation of the NO scavenging activity of procyanidin in grape seed by use of the TMA-PTIO/NOC 7 ESR system. | 2003 | J. Agric. Food Chem. | pmid:14558755 |
| Koh SH et al. | Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3. | 2003 | Brain Res. Mol. Brain Res. | pmid:14559356 |
| Kumagai A et al. | Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins. | 2003 | Bioorg. Med. Chem. | pmid:14604677 |
| Kundu JK et al. | Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells. | 2003 | J. Nutr. | pmid:14608118 |
| RamÃrez-Mares MV and de MejÃa EG | Comparative study of the antioxidant effect of ardisin and epigallocatechin gallate in rat hepatocytes exposed to benomyl and 1-nitropyrene. | 2003 | Food Chem. Toxicol. | pmid:12963005 |
| Weber JM et al. | Inhibition of adenovirus infection and adenain by green tea catechins. | 2003 | Antiviral Res. | pmid:12742577 |
| Yang LL et al. | Antitumor principle constituents of Myrica rubra Var. acuminata. | 2003 | J. Agric. Food Chem. | pmid:12720379 |
| Shi J et al. | Polyphenolics in grape seeds-biochemistry and functionality. | 2003 | J Med Food | pmid:14977436 |
| Seeram NP et al. | Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. | 2003 | Nutr Cancer | pmid:12925310 |
| Bain J et al. | The specificities of protein kinase inhibitors: an update. | 2003 | Biochem. J. | pmid:12534346 |
| Taylor AW et al. | Hop (Humulus lupulus L.) proanthocyanidins characterized by mass spectrometry, acid catalysis, and gel permeation chromatography. | 2003 | J. Agric. Food Chem. | pmid:12822954 |
| Morikawa T et al. | Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. | 2003 | J. Nat. Prod. | pmid:14510595 |
| Suzuki M et al. | Epimerization of tea catechins and O-methylated derivatives of (-)-epigallocatechin-3-O-gallate: relationship between epimerization and chemical structure. | 2003 | J. Agric. Food Chem. | pmid:12517118 |