(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yang R et al. | Chitosan binding onto the epigallocatechin-loaded ferritin nanocage enhances its transport across Caco-2 cells. | 2018 | Food Funct | pmid:29541738 |
| Tuominen A and Karonen M | Variability between organs of proanthocyanidins in Geranium sylvaticum analyzed by off-line 2-dimensional HPLC-MS. | 2018 | Phytochemistry | pmid:29579735 |
| Yang H et al. | The relative antioxidant activity and steric structure of green tea catechins - A kinetic approach. | 2018 | Food Chem | pmid:29622228 |
| Ahmed R and Melacini G | A solution NMR toolset to probe the molecular mechanisms of amyloid inhibitors. | 2018 | Chem. Commun. (Camb.) | pmid:29658548 |
| Park JE et al. | Quantitative Analysis of Four Catechins from Green Tea Extract in Human Plasma Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Pharmacokinetic Studies. | 2018 | Molecules | pmid:29690635 |
| Cabrera R et al. | Bioavailability of Compounds Susceptible to Enzymatic Oxidation Enhances Growth of Shiitake Medicinal Mushroom (Lentinus edodes) in Solid-State Fermentation with Vineyard Prunings. | 2018 | Int J Med Mushrooms | pmid:29717673 |
| Sano T et al. | Effect of shading intensity on morphological and color traits and on chemical components of new tea (Camellia sinensis L.) shoots under direct covering cultivation. | 2018 | J. Sci. Food Agric. | pmid:29722013 |
| Kfoury N et al. | Striking changes in tea metabolites due to elevational effects. | 2018 | Food Chem | pmid:29853384 |
| Longo E et al. | Relative abundances of novel cyclic prodelphinidins in wine depending on the grape variety. | 2018 | J Mass Spectrom | pmid:30107063 |
| Frost S et al. | Characterization of Red Wine Proanthocyanidins Using a Putative Proanthocyanidin Database, Amide Hydrophilic Interaction Liquid Chromatography (HILIC), and Time-of-Flight Mass Spectrometry. | 2018 | Molecules | pmid:30340402 |
| Matsuo T et al. | Identification of (+)-gallocatechin as a bio-antimutagenic compound in Psidium guava leaves. | 1994 | Phytochemistry | pmid:7765204 |
| Du Q et al. | Purification of (-)-epigallocatechin from enzymatic hydrolysate of its gallate using high-speed counter-current chromatography. | 1994 | J Chromatogr A | pmid:7849987 |
| Shi ST et al. | Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice. | 1994 | Cancer Res. | pmid:8062257 |
| Mahmood N et al. | Inhibition of HIV infection by flavanoids. | 1993 | Antiviral Res. | pmid:8279812 |
| Isemura M et al. | Effects of catechins on the mouse lung carcinoma cell adhesion to the endothelial cells. | 1993 | Cell Biol. Int. | pmid:8348114 |
| Ikigai H et al. | Bactericidal catechins damage the lipid bilayer. | 1993 | Biochim. Biophys. Acta | pmid:8466924 |
| Sakanaka S et al. | Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium, Porphyromonas gingivalis. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8704303 |
| Yoshida T et al. | New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. | 1996 | Chem. Pharm. Bull. | pmid:8795264 |
| Yoshiki Y et al. | Mechanism of catechin chemiluminescence in the presence of active oxygen. | 1996 May-Jun | J. Biolumin. Chemilumin. | pmid:8844343 |
| Kakuda T et al. | Effects of tea (Camellia sinensis) chemical compounds on ethanol metabolism in ICR mice. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8987593 |
| Yamanaka N et al. | Green tea catechins such as (-)-epicatechin and (-)-epigallocatechin accelerate Cu2+-induced low density lipoprotein oxidation in propagation phase. | 1997 | FEBS Lett. | pmid:9013893 |
| Stammler G and Volm M | Green tea catechins (EGCG and EGC) have modulating effects on the activity of doxorubicin in drug-resistant cell lines. | 1997 | Anticancer Drugs | pmid:9095331 |
| Zhang A et al. | Inhibitory effects of jasmine green tea epicatechin isomers on free radical-induced lysis of red blood cells. | 1997 | Life Sci. | pmid:9244364 |
| Chen L et al. | Absorption, distribution, elimination of tea polyphenols in rats. | 1997 | Drug Metab. Dispos. | pmid:9311619 |
| Nakagawa K et al. | Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9438978 |
| Cos P et al. | Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. | 1998 | J. Nat. Prod. | pmid:9461655 |
| Kennedy DO et al. | Involvement of protein tyrosine phosphorylation in the effect of green tea polyphenols on Ehrlich ascites tumor cells in vitro. | 1998 | Chem. Biol. Interact. | pmid:9609384 |
| Lu LH et al. | Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK. | 1998 | Br. J. Pharmacol. | pmid:9720795 |
| Kaneko T et al. | Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells by catechins. | 1998 | Chem. Biol. Interact. | pmid:9744559 |
| Bouhamidi R et al. | High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation. | 1998 | C. R. Acad. Sci. III, Sci. Vie | pmid:9759355 |
| Soriani M et al. | Modulation of the UVA activation of haem oxygenase, collagenase and cyclooxygenase gene expression by epigallocatechin in human skin cells. | 1998 | FEBS Lett. | pmid:9845332 |
| Kondo K et al. | Mechanistic studies of catechins as antioxidants against radical oxidation. | 1999 | Arch. Biochem. Biophys. | pmid:9917331 |
| Yang CS et al. | Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies. | 1999 | Cancer Epidemiol. Biomarkers Prev. | pmid:9950244 |