(-)-Epigallocatechin

(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Epigallocatechin?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Liver Diseases D008107 31 associated lipids
Glioblastoma D005909 27 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with (-)-Epigallocatechin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Epigallocatechin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (-)-Epigallocatechin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Epigallocatechin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (-)-Epigallocatechin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Epigallocatechin?

Rodent Model

Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).

Transgenic Model

Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with (-)-Epigallocatechin

Download all related citations
Per page 10 20 50 100 | Total 933
Authors Title Published Journal PubMed Link
Wang ZY et al. Inhibitory effect of green tea on the growth of established skin papillomas in mice. 1992 Cancer Res. pmid:1423310
Shi ST et al. Effects of green tea and black tea on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation, DNA methylation, and lung tumorigenesis in A/J mice. 1994 Cancer Res. pmid:8062257
Guo S et al. Microarray-assisted pathway analysis identifies mitogen-activated protein kinase signaling as a mediator of resistance to the green tea polyphenol epigallocatechin 3-gallate in her-2/neu-overexpressing breast cancer cells. 2006 Cancer Res. pmid:16707458
Slusarz A et al. Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer. 2010 Cancer Res. pmid:20395211
Luo H et al. Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. 2006 Carcinogenesis pmid:15930028
Sun CL et al. Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China. 2002 Carcinogenesis pmid:12189193
Nakagawa H et al. Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate. 2004 Carcinogenesis pmid:15090467
Kim M et al. (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. 2005 Carcinogenesis pmid:15860507
Rathore K et al. Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis. 2012 Carcinogenesis pmid:22045026
Anderson RF et al. Green tea catechins partially protect DNA from (.)OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals. 2001 Carcinogenesis pmid:11470748
Yoo S et al. Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans. 2011 Caries Res. pmid:21720161
Hirasawa M et al. Inhibition of acid production in dental plaque bacteria by green tea catechins. 2006 Caries Res. pmid:16707877
el-Saadany MA et al. Antioxidants modulate the IL-6 induced inhibition of negative acute-phase protein secretion in HepG2 cells. 2008 Jan-Feb Cell Biochem. Funct. pmid:17410531
Isemura M et al. Effects of catechins on the mouse lung carcinoma cell adhesion to the endothelial cells. 1993 Cell Biol. Int. pmid:8348114
Morikawa K et al. Epigallocatechin gallate-induced apoptosis does not affect adipocyte conversion of preadipocytes. 2007 Cell Biol. Int. pmid:17631393
Kaur T et al. Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation. 2011 Cell Death Dis pmid:21776018
Bellosta S et al. Inhibition of metalloproteinase-9 activity and gene expression by polyphenolic compounds isolated from the bark of Tristaniopsis calobuxus (Myrtaceae). 2003 Cell. Mol. Life Sci. pmid:12943230
Yin Y et al. Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR. 2017 Cell. Signal. pmid:28389416
Lin G et al. Enantioselective total syntheses of (+)-gallocatechin, (-)-epigallocatechin, and 8-C-ascorbyl-(-)-epigallocatechin. 2013 Chem Asian J pmid:23362126
Stef DS and Gergen I Effect of mineral-enriched diet and medicinal herbs on Fe, Mn, Zn, and Cu uptake in chicken. 2012 Chem Cent J pmid:22429523
Vodnar DC and Socaciu C Green tea increases the survival yield of Bifidobacteria in simulated gastrointestinal environment and during refrigerated conditions. 2012 Chem Cent J pmid:22727242
Wu Q et al. Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu). 2007 Chem. Biodivers. pmid:18081092
Kaneko T et al. Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells by catechins. 1998 Chem. Biol. Interact. pmid:9744559
Kennedy DO et al. Involvement of protein tyrosine phosphorylation in the effect of green tea polyphenols on Ehrlich ascites tumor cells in vitro. 1998 Chem. Biol. Interact. pmid:9609384
Opare Kennedy D et al. Growth inhibitory effect of green tea extract and (-)-epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases. 2001 Chem. Biol. Interact. pmid:11311209
Cui Y et al. Protective effects of polyphenols-enriched extract from Huangshan Maofeng green tea against CCl4-induced liver injury in mice. 2014 Chem. Biol. Interact. pmid:24973642
Tsuchiya H Stereospecificity in membrane effects of catechins. 2001 Chem. Biol. Interact. pmid:11248221
Ahmed R and Melacini G A solution NMR toolset to probe the molecular mechanisms of amyloid inhibitors. 2018 Chem. Commun. (Camb.) pmid:29658548
Sato M et al. Structural characteristics for superoxide anion radical scavenging and productive activities of green tea polyphenols including proanthocyanidin dimers. 2010 Chem. Pharm. Bull. pmid:20045974
Ikeda H et al. Incompatibility between propericiazine oral solution and tea-based drink. 2012 Chem. Pharm. Bull. pmid:22976331
Wang LQ et al. The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium. 2001 Chem. Pharm. Bull. pmid:11767089
Yoshida T et al. New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors. 1996 Chem. Pharm. Bull. pmid:8795264
Jang JH et al. Analysis of green tea compounds and their stability in dentifrices of different pH levels. 2014 Chem. Pharm. Bull. pmid:24695342
Agusta A et al. Stereoselective oxidation at C-4 of flavans by the endophytic fungus Diaporthe sp. isolated from a tea plant. 2005 Chem. Pharm. Bull. pmid:16327190
Cai YJ et al. Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes. 2002 Chem. Phys. Lipids pmid:12426080
Liu Z et al. Antioxidative effects of green tea polyphenols on free radical initiated and photosensitized peroxidation of human low density lipoprotein. 2000 Chem. Phys. Lipids pmid:10878235
Kawai Y et al. Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage. 2008 Chem. Res. Toxicol. pmid:18512968
Bandele OJ et al. Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. 2008 Chem. Res. Toxicol. pmid:18461976
Lv L et al. Genistein inhibits advanced glycation end product formation by trapping methylglyoxal. 2011 Chem. Res. Toxicol. pmid:21344933
Muzolf-Panek M et al. Role of catechin quinones in the induction of EpRE-mediated gene expression. 2008 Chem. Res. Toxicol. pmid:19548356
Palermo CM et al. Identification of potential aryl hydrocarbon receptor antagonists in green tea. 2003 Chem. Res. Toxicol. pmid:12870889
Valcic S et al. Antioxidant chemistry of green tea catechins. New oxidation products of (-)-epigallocatechin gallate and (-)-epigallocatechin from their reactions with peroxyl radicals. 2000 Chem. Res. Toxicol. pmid:10995252
Cao P et al. Effect of green tea catechins and hydrolyzable tannins on benzo[a]pyrene-induced DNA adducts and structure-activity relationship. 2010 Chem. Res. Toxicol. pmid:20218540
Li C et al. Analysis of urinary metabolites of tea catechins by liquid chromatography/electrospray ionization mass spectrometry. 2001 Chem. Res. Toxicol. pmid:11409941
Ferrer-Gallego R et al. Characterization of Sensory Properties of Flavanols - A Molecular Dynamic Approach. 2015 Chem. Senses pmid:25934978
Neshchadin D et al. Probing the antioxidant activity of polyphenols by CIDNP: from model compounds to green tea and red wine. 2010 Chemistry pmid:20440723
Zhang Y et al. Simultaneous quantification of ten constituents of Xanthoceras sorbifolia Bunge using UHPLC-MS methods and evaluation of their radical scavenging, DNA scission protective, and α-glucosidase inhibitory activities. 2015 Chin J Nat Med pmid:26614463
Yang CH et al. Supplementary catechins attenuate cooking-oil-fumes-induced oxidative stress in rat lung. 2009 Chin J Physiol pmid:19777801
Chacko SM et al. Beneficial effects of green tea: a literature review. 2010 Chin Med pmid:20370896
Liu J et al. Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies. 2008 Chin Med pmid:18940008
Park SJ et al. Effects of Epigallocatechin-3-Gallate on the Expression of TGF-β1, PKC α/βII, and NF-κB in High-Glucose-Stimulated Glomerular Epithelial Cells. 2011 Chonnam Med J pmid:22111071
Markus MA and Morris BJ Resveratrol in prevention and treatment of common clinical conditions of aging. 2008 Clin Interv Aging pmid:18686754
Chow HH et al. Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. 2005 Clin. Cancer Res. pmid:15958649
Chow HH et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. 2003 Clin. Cancer Res. pmid:12960117
Rizvi SI et al. Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes. Clin. Exp. Pharmacol. Physiol. pmid:15730438
Shen JZ et al. Green tea catechins evoke a phasic contraction in rat aorta via H2O2-mediated multiple-signalling pathways. Clin. Exp. Pharmacol. Physiol. pmid:12542460
Mak JC Potential role of green tea catechins in various disease therapies: progress and promise. 2012 Clin. Exp. Pharmacol. Physiol. pmid:22229384
Chen CH et al. An in vitro hyperbaric oxygen system for evaluation of free radical damage and protection by catechins on hemorheological parameters. 2011 Clin. Hemorheol. Microcirc. pmid:22012826
Safety assessment and potential health benefits of food components based on selected scientific criteria. ILSI North America Technical Committee on Food Components for Health Promotion. 1999 Crit Rev Food Sci Nutr pmid:10367185
Kim DO and Lee CY Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. 2004 Crit Rev Food Sci Nutr pmid:15462129
Butt MS and Sultan MT Green tea: nature's defense against malignancies. 2009 Crit Rev Food Sci Nutr pmid:19399671
Lamoral-Theys D et al. Natural polyphenols that display anticancer properties through inhibition of kinase activity. 2010 Curr. Med. Chem. pmid:20156174
Magrone T et al. Human use of Leucoselect® Phytosome® with special reference to inflammatory-allergic pathologies in frail elderly patients. 2014 Curr. Pharm. Des. pmid:23701566
Crouvezier S et al. The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro. 2001 Cytokine pmid:11243706
Maeda-Yamamoto M et al. Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study. 2011 Cytotechnology pmid:21207145
Monobe M et al. Enhancement of phagocytic activity of macrophage-like cells by pyrogallol-type green tea polyphenols through caspase signaling pathways. 2010 Cytotechnology pmid:20502963
Koparal AT et al. Differential effect of green tea catechins on three endothelial cell clones isolated from rat adipose tissue and on human umbilical vein endothelial cells. 2004 Cytotechnology pmid:19003256
Neveu V et al. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. 2010 Database (Oxford) pmid:20428313
Andersson LE et al. Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase. 2018 Diabetes pmid:29229616
Tucci SA et al. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents. 2010 Diabetes Metab Syndr Obes pmid:21437083
Mirkov S et al. Effects of green tea compounds on irinotecan metabolism. 2007 Drug Metab. Dispos. pmid:17108060
Chen L et al. Absorption, distribution, elimination of tea polyphenols in rats. 1997 Drug Metab. Dispos. pmid:9311619
Cai Y et al. Contribution of presystemic hepatic extraction to the low oral bioavailability of green tea catechins in rats. 2002 Drug Metab. Dispos. pmid:12386131
Meng X et al. Formation and identification of 4'-O-methyl-(-)-epigallocatechin in humans. 2001 Drug Metab. Dispos. pmid:11353745
Lu H et al. Glucuronides of tea catechins: enzymology of biosynthesis and biological activities. 2003 Drug Metab. Dispos. pmid:12642472
Lu H et al. Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate. 2003 Drug Metab. Dispos. pmid:12695345
Fisher-Wellman K and Bloomer RJ Acute exercise and oxidative stress: a 30 year history. 2009 Dyn Med pmid:19144121
Pomponio R et al. Microemulsion electrokinetic chromatography for the analysis of green tea catechins: effect of the cosurfactant on the separation selectivity. 2003 Electrophoresis pmid:12761797
Gotti R et al. Differentiation of green tea samples by chiral CD-MEKC analysis of catechins content. 2009 Electrophoresis pmid:19637216
Zhang H et al. Improving sensitivity by large-volume sample stacking combined with sweeping without polarity switching by capillary electrophoresis coupled to photodiode array ultraviolet detection. 2008 Electrophoresis pmid:18384029
Huang HY and Lien WC Analyses of phenolic compounds by microemulsion electrokinetic chromatography. 2005 Electrophoresis pmid:16041702
Kodama S et al. Direct enantioseparation of catechin and epicatechin in tea drinks by 6-O-alpha-D-glucosyl-beta-cyclodextrin-modified micellar electrokinetic chromatography. 2004 Electrophoresis pmid:15352024
Huang HY et al. Sample stacking for the analysis of catechins by microemulsion EKC. 2007 Electrophoresis pmid:17464960
Rodríguez-Durán LV et al. Novel strategies for upstream and downstream processing of tannin acyl hydrolase. 2011 Enzyme Res pmid:21941633
Kang H et al. Green tea consumption and stomach cancer risk: a meta-analysis. 2010 Epidemiol Health pmid:21191454
Park KD and Cho SJ Synthesis and antimicrobial activities of 3-O-alkyl analogues of (+)-catechin: improvement of stability and proposed action mechanism. 2010 Eur J Med Chem pmid:19962795
Lin SF et al. Synthesis and structure-activity relationship of 3-O-acylated (-)-epigallocatechins as 5α-reductase inhibitors. 2010 Eur J Med Chem pmid:21044810
Egert S et al. Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans. 2013 Eur J Nutr pmid:22366739
Pękal A et al. Evaluation of the antioxidant properties of fruit and flavoured black teas. 2011 Eur J Nutr pmid:21360165
Zinellu A et al. N- and S-homocysteinylation reduce the binding of human serum albumin to catechins. 2017 Eur J Nutr pmid:26658763
Miller RJ et al. A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins. 2012 Eur J Nutr pmid:21445620
Cudmore MJ et al. Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1. 2012 Eur. Heart J. pmid:21411816
Bastianetto S et al. Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. 2006 Eur. J. Neurosci. pmid:16420415
Kim TH et al. Effects of (-) epigallocatechin-3-gallate on Na(+) currents in rat dorsal root ganglion neurons. 2009 Eur. J. Pharmacol. pmid:19111536
Roy S et al. Combination therapy of dexamethasone with epigallocatechin enhances tibiotarsal bone articulation and modulates oxidative status correlates with cartilage cytokines expression in the early phase of experimental arthritis. 2013 Eur. J. Pharmacol. pmid:23183110
Locher R et al. Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. 2002 Eur. J. Pharmacol. pmid:11755158
Obara K et al. Mechanism of potentiation by tea epigallocatechin of contraction in porcine coronary artery: the role of protein kinase Cδ-mediated CPI-17 phosphorylation. 2011 Eur. J. Pharmacol. pmid:21827748
Ravindranath MH et al. Differential growth suppression of human melanoma cells by tea (Camellia sinensis) epicatechins (ECG, EGC and EGCG). 2009 Evid Based Complement Alternat Med pmid:18955299
Wang SC et al. Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3γ in an Experimental Animal Model. 2011 Evid Based Complement Alternat Med pmid:19965962
Park CH et al. Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging. 2012 Evid Based Complement Alternat Med pmid:22649473