(-)-Epigallocatechin

(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Epigallocatechin?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Liver Diseases D008107 31 associated lipids
Glioblastoma D005909 27 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with (-)-Epigallocatechin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Epigallocatechin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with (-)-Epigallocatechin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Epigallocatechin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with (-)-Epigallocatechin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Epigallocatechin?

Rodent Model

Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).

Transgenic Model

Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with (-)-Epigallocatechin

Download all related citations
Per page 10 20 50 100 | Total 933
Authors Title Published Journal PubMed Link
Kinjo J et al. Activity-guided fractionation of green tea extract with antiproliferative activity against human stomach cancer cells. 2002 Biol. Pharm. Bull. pmid:12230128
Kushima Y et al. Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line. 2009 Biol. Pharm. Bull. pmid:19420761
Li F et al. Inhibitory effect of catechin-related compounds on renin activity. 2013 Biomed. Res. pmid:23782751
Matsuda H et al. Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. 2011 Bioorg. Med. Chem. pmid:21493073
Ishii T et al. Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin. 2010 Bioorg. Med. Chem. pmid:20598557
Huo C et al. Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs. 2010 Bioorg. Med. Chem. pmid:20045338
Shin ES et al. Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. 2008 Bioorg. Med. Chem. pmid:18313308
Manir MM et al. Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase. 2012 Bioorg. Med. Chem. pmid:22377672
Kumagai A et al. Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins. 2003 Bioorg. Med. Chem. pmid:14604677
Kim JA et al. New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H. 2011 Bioorg. Med. Chem. Lett. pmid:21489793
Tillekeratne LM et al. Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase. 2002 Bioorg. Med. Chem. Lett. pmid:11844664
Aihara Y et al. Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. 2009 Bioorg. Med. Chem. Lett. pmid:19524436
Uesato S et al. Antitumor promoting activities of 3-O-acyl-(-)epigallocatechins. 2000 Bioorg. Med. Chem. Lett. pmid:10937722
Jeon SY et al. Green tea catechins as a BACE1 (beta-secretase) inhibitor. 2003 Bioorg. Med. Chem. Lett. pmid:14592472
Lambert JD et al. Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives. 2005 Bioorg. Med. Chem. Lett. pmid:15686878
Kumamoto M et al. Effects of pH and metal ions on antioxidative activities of catechins. 2001 Biosci. Biotechnol. Biochem. pmid:11272815
Hayakawa F et al. Prooxidative activities of tea catechins in the presence of Cu2+. 2004 Biosci. Biotechnol. Biochem. pmid:15388955
Suzuki Y et al. Dose-dependent suppression of tea catechins with a galloyl moiety on postprandial hypertriglyceridemia in rats. 2005 Biosci. Biotechnol. Biochem. pmid:16041132
Hayashi N et al. Reduction of catechin astringency by the complexation of gallate-type catechins with pectin. 2005 Biosci. Biotechnol. Biochem. pmid:16041135
Mun'im A et al. Antioxidative compounds from Crotalaria sessiliflora. 2003 Biosci. Biotechnol. Biochem. pmid:12729010
Cheruiyot EK et al. Shoot epicatechin and epigallocatechin contents respond to water stress in tea [Camellia sinensis (L.) O. Kuntze]. 2008 Biosci. Biotechnol. Biochem. pmid:18460799
Sakanaka S et al. Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium, Porphyromonas gingivalis. 1996 Biosci. Biotechnol. Biochem. pmid:8704303
Nakagawa K et al. Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3-gallate and (-)-epigallocatechin, into human plasma. 1997 Biosci. Biotechnol. Biochem. pmid:9438978
Nomizu K et al. Antioxidants from steamed used tea leaves and their reaction behavior. 2008 Biosci. Biotechnol. Biochem. pmid:18603807
Kakuda T et al. Effects of tea (Camellia sinensis) chemical compounds on ethanol metabolism in ICR mice. 1996 Biosci. Biotechnol. Biochem. pmid:8987593
Koyama K et al. Influence of maceration temperature in red wine vinification on extraction of phenolics from berry skins and seeds of grape (Vitis vinifera). 2007 Biosci. Biotechnol. Biochem. pmid:17420579
Okushio K et al. Methylation of tea catechins by rat liver homogenates. 1999 Biosci. Biotechnol. Biochem. pmid:10192923
Furuyashiki T et al. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. 2004 Biosci. Biotechnol. Biochem. pmid:15564676
Hong YH et al. Enzymatic improvement in the polyphenol extractability and antioxidant activity of green tea extracts. 2013 Biosci. Biotechnol. Biochem. pmid:23291774
Kajiya K et al. Effects of external factors on the interaction of tea catechins with lipid bilayers. 2002 Biosci. Biotechnol. Biochem. pmid:12506968
Yoshioka H et al. Spin-trapping study on the hydroxyl radical formed from a tea catechin-Cu(II) system. 2001 Biosci. Biotechnol. Biochem. pmid:11577706
Kida K et al. Deodorizing effects of tea catechins on amines and ammonia. 2002 Biosci. Biotechnol. Biochem. pmid:11999411
Murakami C et al. Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells. 2002 Biosci. Biotechnol. Biochem. pmid:12224642
Hashimoto T et al. Interaction of tea catechins with lipid bilayers investigated with liposome systems. 1999 Biosci. Biotechnol. Biochem. pmid:10664864
Hayakawa F et al. DNA cleavage activities of (-)-epigallocatechin, (-)-epicatechin, (+)-catechin, and (-)-epigallocatechin gallate with various kinds of metal ions. 1999 Biosci. Biotechnol. Biochem. pmid:10610127
Monobe M et al. Effect on the epigallocatechin gallate/epigallocatechin ratio in a green tea (Camellia sinensis L.) extract of different extraction temperatures and its effect on IgA production in mice. 2010 Biosci. Biotechnol. Biochem. pmid:21150115
Mori T et al. Covalent binding of tea catechins to protein thiols: the relationship between stability and electrophilic reactivity. 2010 Biosci. Biotechnol. Biochem. pmid:21150116
Ishii T et al. Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization. 2011 Biosci. Biotechnol. Biochem. pmid:21228463
Monobe M et al. Increased plasma concentration of epigallocatechin in mice after orally administering a green tea (Camellia sinensis L.) extract supplemented by steamed rice. 2011 Biosci. Biotechnol. Biochem. pmid:21228465
Jiang Y et al. Immunoregulatory and anti-HIV-1 enzyme activities of antioxidant components from lotus (Nelumbo nucifera Gaertn.) rhizome. 2011 Biosci. Rep. pmid:21114474
Jin Y et al. Separation of catechin compounds from different teas. 2006 Biotechnol J pmid:16892250
Schantz M et al. Metabolism of green tea catechins by the human small intestine. 2010 Biotechnol J pmid:20931601
Zhong K et al. Enzymatic production of epigallocatechin by using an epigallocatechin gallate hydrolase induced from Aspergillus oryzae. 2008 May-Jun Biotechnol. Prog. pmid:18452340
Rajavelu A et al. The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. 2011 BMC Biochem. pmid:21510884
Stingl JC et al. Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. 2011 BMC Cancer pmid:21851602
Moran DM et al. Puromycin-based vectors promote a ROS-dependent recruitment of PML to nuclear inclusions enriched with HSP70 and Proteasomes. 2009 BMC Cell Biol. pmid:19409099
Lehnert M et al. Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats. 2010 BMC Complement Altern Med pmid:20735845
Wagner AE et al. Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2. 2011 BMC Complement Altern Med pmid:21199573
Zor M et al. Antigenotoxic properties of Paliurus spina-christi Mill fruits and their active compounds. 2017 BMC Complement Altern Med pmid:28446228
Rahman S et al. In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines. 2011 BMC Complement Altern Med pmid:21933433