(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yousef GG et al. | Comparative phytochemical characterization of three Rhodiola species. | 2006 | Phytochemistry | pmid:16956631 |
| Das A et al. | Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids. | 2006 | Int. J. Cancer | pmid:16988947 |
| Han KH et al. | A water extract of Artemisia capillaris prevents 2,2'-azobis(2-amidinopropane) dihydrochloride-induced liver damage in rats. | 2006 | J Med Food | pmid:17004896 |
| Luximon-Ramma A et al. | Assessment of the polyphenolic composition of the organic extracts of Mauritian black teas: a potential contributor to their antioxidant functions. | 2006 | Biofactors | pmid:17012766 |
| Ko CH et al. | Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-deficient erythrocytes in vitro. | 2006 | Int. J. Mol. Med. | pmid:17016632 |
| Xu J et al. | Mixed-mode retention mechanism for (-)-epigallocatechin gallate on a 12% cross-linked agarose gel media. | 2006 | J Chromatogr A | pmid:17049539 |
| Tang FY et al. | Green tea catechin inhibits ephrin-A1-mediated cell migration and angiogenesis of human umbilical vein endothelial cells. | 2007 | J. Nutr. Biochem. | pmid:17049832 |
| Cortell JM and Kennedy JA | Effect of shading on accumulation of flavonoid compounds in (Vitis vinifera L.) pinot noir fruit and extraction in a model system. | 2006 | J. Agric. Food Chem. | pmid:17061828 |
| Park YJ et al. | [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. | 2006 | Yonsei Med. J. | pmid:17066513 |
| Haginaka J et al. | Uniformly-sized, molecularly imprinted polymers for (-)-epigallocatechin gallate, -epicatechin gallate and -gallocatechin gallate by multi-step swelling and polymerization method. | 2007 | J Chromatogr A | pmid:17070533 |
| Günther S et al. | Polyphenols prevent cell shedding from mouse mammary cancer spheroids and inhibit cancer cell invasion in confrontation cultures derived from embryonic stem cells. | 2007 | Cancer Lett. | pmid:17070989 |
| Annabi B et al. | Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg. | 2007 | Leuk. Res. | pmid:17081606 |
| Hamada M et al. | TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. | 2006 | J. Agric. Food Chem. | pmid:17090139 |
| Lo CY et al. | Trapping reactions of reactive carbonyl species with tea polyphenols in simulated physiological conditions. | 2006 | Mol Nutr Food Res | pmid:17103374 |
| Mirkov S et al. | Effects of green tea compounds on irinotecan metabolism. | 2007 | Drug Metab. Dispos. | pmid:17108060 |
| Alemdaroglu NC et al. | Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells. | 2007 | Planta Med. | pmid:17117344 |
| Changotade SI et al. | Epigallocatechin gallate's protective effect against MMP7 in recessive dystrophic epidermolysis bullosa patients. | 2007 | J. Invest. Dermatol. | pmid:17139264 |
| Venzie JL et al. | Electron-impact and glow-discharge ionization LC-MS analysis of green tea tincture. | 2007 | Anal Bioanal Chem | pmid:17139484 |
| Pajonk F et al. | The effects of tea extracts on proinflammatory signaling. | 2006 | BMC Med | pmid:17140430 |
| Gagné S et al. | Composition and cellular localization of tannins in Cabernet Sauvignon skins during growth. | 2006 | J. Agric. Food Chem. | pmid:17147434 |
| Yuan JM et al. | Urinary biomarkers of tea polyphenols and risk of colorectal cancer in the Shanghai Cohort Study. | 2007 | Int. J. Cancer | pmid:17149697 |
| Kim SY et al. | Application of far-infrared irradiation in the manufacturing process of green tea. | 2006 | J. Agric. Food Chem. | pmid:17177525 |
| Harnly JM et al. | Flavonoid content of U.S. fruits, vegetables, and nuts. | 2006 | J. Agric. Food Chem. | pmid:17177529 |
| Ogasawara M et al. | Differential effects of antioxidants on the in vitro invasion, growth and lung metastasis of murine colon cancer cells. | 2007 | Biol. Pharm. Bull. | pmid:17202688 |
| Cao H et al. | Green tea increases anti-inflammatory tristetraprolin and decreases pro-inflammatory tumor necrosis factor mRNA levels in rats. | 2007 | J Inflamm (Lond) | pmid:17207279 |
| Gradisar H et al. | Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site. | 2007 | J. Med. Chem. | pmid:17228868 |
| Ebina T and Tsukada K | Protease inhibitors prevent the development of human rotavirus-induced diarrhea in suckling mice. | 1991 | Microbiol. Immunol. | pmid:1723785 |
| Sharma SK et al. | Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). | 2007 | J. Med. Chem. | pmid:17263522 |
| Koo SI and Noh SK | Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect. | 2007 | J. Nutr. Biochem. | pmid:17296491 |
| Kotani A et al. | Attomole catechins determination by capillary liquid chromatography with electrochemical detection. | 2007 | Anal Sci | pmid:17297226 |
| Li Y et al. | Oxidative coupling of the pyrogallol B-ring with a galloyl group during enzymatic oxidation of epigallocatechin 3-O-gallate. | 2007 | Phytochemistry | pmid:17320123 |
| Chan KY et al. | Intestinal efflux transport kinetics of green tea catechins in Caco-2 monolayer model. | 2007 | J. Pharm. Pharmacol. | pmid:17331343 |
| Lode HN et al. | Nutrient mixture including vitamin C, L-lysine, L-proline, and epigallocatechin is ineffective against tumor growth and metastasis in a syngeneic neuroblastoma model. | 2008 | Pediatr Blood Cancer | pmid:17366537 |
| Omoigui S | The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | 2007 | Immun Ageing | pmid:17374166 |
| Lee SJ et al. | Phenolic phytochemicals derived from red pine (Pinus densiflora) inhibit the invasion and migration of SK-Hep-1 human hepatocellular carcinoma cells. | 2007 | Ann. N. Y. Acad. Sci. | pmid:17404067 |
| Fernández K et al. | Characterization of Vitis vinifera L. Cv. Carménère grape and wine proanthocyanidins. | 2007 | J. Agric. Food Chem. | pmid:17407309 |
| el-Saadany MA et al. | Antioxidants modulate the IL-6 induced inhibition of negative acute-phase protein secretion in HepG2 cells. | 2008 Jan-Feb | Cell Biochem. Funct. | pmid:17410531 |
| Koyama K et al. | Influence of maceration temperature in red wine vinification on extraction of phenolics from berry skins and seeds of grape (Vitis vinifera). | 2007 | Biosci. Biotechnol. Biochem. | pmid:17420579 |
| Li YM et al. | Green tea catechins upregulate superoxide dismutase and catalase in fruit flies. | 2007 | Mol Nutr Food Res | pmid:17440995 |
| Yun JH et al. | (-)-Epigallocatechin gallate induces apoptosis, via caspase activation, in osteoclasts differentiated from RAW 264.7 cells. | 2007 | J. Periodont. Res. | pmid:17451540 |
| Huang HY et al. | Sample stacking for the analysis of catechins by microemulsion EKC. | 2007 | Electrophoresis | pmid:17464960 |
| Shin JK et al. | Antioxidant and pro-oxidant effects of green tea extracts in oxygen radical absorbance capacity assay. | 2007 | J Med Food | pmid:17472464 |
| Yamamoto S et al. | Rational method for designing efficient separations by chromatography on polystyrene-divinylbenzene resins eluted with aqueous ethanol. | 2007 | J Chromatogr A | pmid:17498724 |
| Alcalde-Eon C et al. | Identification of dimeric anthocyanins and new oligomeric pigments in red wine by means of HPLC-DAD-ESI/MSn. | 2007 | J Mass Spectrom | pmid:17511019 |
| Hao J et al. | Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats. | 2007 | J. Vet. Sci. | pmid:17519564 |
| Pan MH et al. | Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. | 2007 | J. Agric. Food Chem. | pmid:17539658 |
| Makena PS and Chung KT | Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. | 2007 | Food Chem. Toxicol. | pmid:17560706 |
| Morikawa K et al. | Epigallocatechin gallate-induced apoptosis does not affect adipocyte conversion of preadipocytes. | 2007 | Cell Biol. Int. | pmid:17631393 |
| Wang ZG et al. | Effect of supplementation of green tea polyphenols on the developmental competence of bovine oocytes in vitro. | 2007 | Braz. J. Med. Biol. Res. | pmid:17665044 |
| Katavic PL et al. | Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships. | 2007 | J. Nat. Prod. | pmid:17685652 |
| Green RJ et al. | Common tea formulations modulate in vitro digestive recovery of green tea catechins. | 2007 | Mol Nutr Food Res | pmid:17688297 |
| Niemeyer ED and Brodbelt JS | Isomeric differentiation of green tea catechins using gas-phase hydrogen/deuterium exchange reactions. | 2007 | J. Am. Soc. Mass Spectrom. | pmid:17702600 |
| Song JM et al. | Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives. | 2007 | Antiviral Res. | pmid:17709148 |
| Lin CL et al. | Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. | 2007 | J. Lipid Res. | pmid:17720960 |
| Matsuo Y et al. | Enzymatic oxidation of gallocatechin and epigallocatechin: effects of C-ring configuration on the reaction products. | 2008 | Phytochemistry | pmid:17888464 |
| Wang JS et al. | Validation of green tea polyphenol biomarkers in a phase II human intervention trial. | 2008 | Food Chem. Toxicol. | pmid:17888558 |
| Neilson AP et al. | Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion. | 2007 | J. Agric. Food Chem. | pmid:17924707 |
| Li W et al. | A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. | 2007 | PLoS ONE | pmid:17987129 |
| Nguyen M et al. | Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18040043 |
| Letchoumy PV et al. | Comparative evaluation of antiproliferative, antiangiogenic and apoptosis inducing potential of black tea polyphenols in the hamster buccal pouch carcinogenesis model. | 2007 | J Carcinog | pmid:18053169 |
| Niedzwiecki A | Micronutrient mixture in tumor growth and metastasis. | 2008 | Pediatr Blood Cancer | pmid:18061931 |
| Yang SW et al. | Protective effects of epigallocatechin gallate after UV irradiation in cultured human retinal pigment epithelial cells. | 2007 | Korean J Ophthalmol | pmid:18063889 |
| Kuzuhara T et al. | Green tea catechin as a chemical chaperone in cancer prevention. | 2008 | Cancer Lett. | pmid:18068893 |
| Wu Q et al. | Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu). | 2007 | Chem. Biodivers. | pmid:18081092 |
| Shen CL et al. | Protective effect of green tea polyphenols on bone loss in middle-aged female rats. | 2008 | Osteoporos Int | pmid:18084689 |
| Kajiya K et al. | Solid-state NMR analysis of the orientation and dynamics of epigallocatechin gallate, a green tea polyphenol, incorporated into lipid bilayers. | 2008 | Magn Reson Chem | pmid:18098154 |
| Neyestani TR et al. | Selective microbiologic effects of tea extract on certain antibiotics against Escherichia coli in vitro. | 2007 | J Altern Complement Med | pmid:18166124 |
| Inaba H et al. | Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (--)-epigallocatechin against HCT116 colorectal carcinoma cells. | 2008 | Biol. Pharm. Bull. | pmid:18175946 |
| Amici M et al. | Wheat sprout extract induces changes on 20S proteasomes functionality. | 2008 | Biochimie | pmid:18190797 |
| Zhu BT et al. | Molecular modelling study of the mechanism of high-potency inhibition of human catechol-O-methyltransferase by (-)-epigallocatechin-3-O-gallate. | 2008 | Xenobiotica | pmid:18197555 |
| Jin YR et al. | Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209568 |
| Son YH et al. | Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells. | 2008 | J. Cardiovasc. Pharmacol. | pmid:18209571 |
| Chen XN et al. | Radical scavenging activity and phenolic compounds in persimmon (Diospyros kaki L. cv. Mopan). | 2008 | J. Food Sci. | pmid:18211345 |
| de Souza LM et al. | HPLC/ESI-MS and NMR analysis of flavonoids and tannins in bioactive extract from leaves of Maytenus ilicifolia. | 2008 | J Pharm Biomed Anal | pmid:18215490 |
| Devika PT and Mainzen Prince PS | (-)-Epigallocatechin gallate (EGCG) prevents isoprenaline-induced cardiac marker enzymes and membrane-bound ATPases. | 2008 | J. Pharm. Pharmacol. | pmid:18251087 |
| Shim JS et al. | The effects of panduratin A isolated from Kaempferia pandurata on the expression of matrix metalloproteinase-1 and type-1 procollagen in human skin fibroblasts. | 2008 | Planta Med. | pmid:18253916 |
| Zhang B et al. | Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro. | 2008 | Brain Res. | pmid:18255049 |
| Sasazuki S et al. | Plasma tea polyphenols and gastric cancer risk: a case-control study nested in a large population-based prospective study in Japan. | 2008 | Cancer Epidemiol. Biomarkers Prev. | pmid:18268118 |
| Haque AM et al. | Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats. | 2008 | J. Nutr. Biochem. | pmid:18280729 |
| Shin ES et al. | Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. | 2008 | Bioorg. Med. Chem. | pmid:18313308 |
| Sánchez-del-Campo L et al. | Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate. | 2008 | J. Med. Chem. | pmid:18324763 |
| Yao K et al. | Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent apoptosis in human lens epithelial cells. | 2008 | Mol. Vis. | pmid:18334937 |
| Pietrovski EF et al. | Topical anti-inflammatory activity of Eugenia brasiliensis Lam. (Myrtaceae) leaves. | 2008 | J. Pharm. Pharmacol. | pmid:18380921 |
| Zhang H et al. | Improving sensitivity by large-volume sample stacking combined with sweeping without polarity switching by capillary electrophoresis coupled to photodiode array ultraviolet detection. | 2008 | Electrophoresis | pmid:18384029 |
| Mukai D et al. | Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans. | 2008 | J Nat Med | pmid:18404315 |
| Hazgui S et al. | Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells. | 2008 | Respir. Res. | pmid:18426555 |
| Sang S et al. | Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18433082 |
| Wang K et al. | Preparative isolation and purification of theaflavins and catechins by high-speed countercurrent chromatography. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18436487 |
| Kuzuhara T et al. | Generation of mouse monoclonal antibody against (-)-epigallocatechin gallate. | 2008 | Biol. Pharm. Bull. | pmid:18451499 |
| Zhong K et al. | Enzymatic production of epigallocatechin by using an epigallocatechin gallate hydrolase induced from Aspergillus oryzae. | 2008 May-Jun | Biotechnol. Prog. | pmid:18452340 |
| Cheruiyot EK et al. | Shoot epicatechin and epigallocatechin contents respond to water stress in tea [Camellia sinensis (L.) O. Kuntze]. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18460799 |
| Bandele OJ et al. | Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. | 2008 | Chem. Res. Toxicol. | pmid:18461976 |
| Nomura S et al. | Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue. | 2008 | J. Nutr. Biochem. | pmid:18479902 |
| Ortiz J et al. | Interaction of environmental moisture with powdered green tea formulations: effect on catechin chemical stability. | 2008 | J. Agric. Food Chem. | pmid:18489105 |
| Mitani S et al. | Stopped-flow kinetic study of the aroxyl radical-scavenging action of catechins and vitamin C in ethanol and micellar solutions. | 2008 | J. Agric. Food Chem. | pmid:18500808 |
| Kawai Y et al. | Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage. | 2008 | Chem. Res. Toxicol. | pmid:18512968 |
| Moon HS et al. | Physico-chemical modifications of conjugated linoleic acid for ruminal protection and oxidative stability. | 2008 | Nutr Metab (Lond) | pmid:18513443 |
| Neukam K et al. | Tea flavanols inhibit cell growth and DNA topoisomerase II activity and induce endoreduplication in cultured Chinese hamster cells. | 2008 | Mutat. Res. | pmid:18541453 |
| Hisamura F et al. | Synergistic effect of green tea polyphenols on their protection against FK506-induced cytotoxicity in renal cells. | 2008 | Am. J. Chin. Med. | pmid:18543393 |
| Dai F et al. | Antioxidant synergism of green tea polyphenols with alpha-tocopherol and L-ascorbic acid in SDS micelles. | 2008 | Biochimie | pmid:18554517 |