(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nunn AV et al. | Inflammatory modulation of exercise salience: using hormesis to return to a healthy lifestyle. | 2010 | Nutr Metab (Lond) | pmid:21143891 |
| Shen CL et al. | Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report. | 2010 | BMC Complement Altern Med | pmid:21143878 |
| Josic J et al. | Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial. | 2010 | Nutr J | pmid:21118565 |
| Gravina GL et al. | Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation. | 2010 | Mol. Cancer | pmid:21108789 |
| Kelsey NA et al. | Nutraceutical antioxidants as novel neuroprotective agents. | 2010 | Molecules | pmid:21060289 |
| Janecki A and Kolodziej H | Anti-adhesive activities of flavan-3-ols and proanthocyanidins in the interaction of group A-streptococci and human epithelial cells. | 2010 | Molecules | pmid:20953158 |
| Scola G et al. | Flavan-3-ol compounds from wine wastes with in vitro and in vivo antioxidant activity. | 2010 | Nutrients | pmid:22253995 |
| Ahmed S | Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise. | 2010 | Arthritis Res. Ther. | pmid:20447316 |
| Renouf M et al. | Plasma appearance and correlation between coffee and green tea metabolites in human subjects. | 2010 | Br. J. Nutr. | pmid:20691128 |
| Jimenez-Del-Rio M et al. | The effects of polyphenols on survival and locomotor activity in Drosophila melanogaster exposed to iron and paraquat. | 2010 | Neurochem. Res. | pmid:19701790 |
| Song DK et al. | Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. | 2010 | J. Korean Med. Sci. | pmid:20191036 |
| Neveu V et al. | Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. | 2010 | Database (Oxford) | pmid:20428313 |
| Wang P et al. | Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols. | 2010 | PLoS ONE | pmid:20419137 |
| Xia EQ et al. | Biological activities of polyphenols from grapes. | 2010 | Int J Mol Sci | pmid:20386657 |
| Lee SM et al. | Protective effect of catechin on apoptosis of the lens epithelium in rats with N-methyl-N-nitrosourea-induced cataracts. | 2010 | Korean J Ophthalmol | pmid:20379460 |
| Chacko SM et al. | Beneficial effects of green tea: a literature review. | 2010 | Chin Med | pmid:20370896 |
| Zielinsky P et al. | Maternal consumption of polyphenol-rich foods in late pregnancy and fetal ductus arteriosus flow dynamics. | 2010 | J Perinatol | pmid:19641513 |
| Huo C et al. | Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs. | 2010 | Bioorg. Med. Chem. | pmid:20045338 |
| Hayashi N et al. | Beta-cyclodextrin/surface plasmon resonance detection system for sensing bitter-astringent taste intensity of green tea catechins. | 2010 | J. Agric. Food Chem. | pmid:20572674 |
| Kamruzzaman SM et al. | Inhibitory effects of Bulnesia sarmienti aqueous extract on agonist-induced platelet activation and thrombus formation involves mitogen-activated protein kinases. | 2010 | J Ethnopharmacol | pmid:20558266 |
| Li JH et al. | Chemosystematics of tea trees based on tea leaf polyphenols as phenetic markers. | 2010 | Phytochemistry | pmid:20553697 |
| Miyata M et al. | The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site. | 2010 | Biochemistry | pmid:20565072 |
| Schantz M et al. | Metabolism of green tea catechins by the human small intestine. | 2010 | Biotechnol J | pmid:20931601 |
| Gundimeda U et al. | Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. | 2010 | J. Neurosci. Res. | pmid:20936703 |
| Canon F et al. | Ability of a salivary intrinsically unstructured protein to bind different tannin targets revealed by mass spectrometry. | 2010 | Anal Bioanal Chem | pmid:20665010 |
| Nakayama K et al. | Storage and allogeneic transplantation of peripheral nerve using a green tea polyphenol solution in a canine model. | 2010 | J Brachial Plex Peripher Nerve Inj | pmid:21110896 |
| Chan CM et al. | Effects of (-)-epigallocatechin gallate on RPE cell migration and adhesion. | 2010 | Mol. Vis. | pmid:20376327 |
| Lee JE et al. | Geographical and climatic dependencies of green tea (Camellia sinensis) metabolites: a (1)H NMR-based metabolomics study. | 2010 | J. Agric. Food Chem. | pmid:20828156 |
| Russo M et al. | Phytochemicals in cancer prevention and therapy: truth or dare? | 2010 | Toxins (Basel) | pmid:22069598 |
| Slusarz A et al. | Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer. | 2010 | Cancer Res. | pmid:20395211 |
| Bae HB et al. | The effect of epigallocatechin gallate on lipopolysaccharide-induced acute lung injury in a murine model. | 2010 | Inflammation | pmid:19838780 |
| Hanhineva K et al. | Impact of dietary polyphenols on carbohydrate metabolism. | 2010 | Int J Mol Sci | pmid:20480025 |
| Luo J et al. | Urinary polyphenols and breast cancer risk: results from the Shanghai Women's Health Study. | 2010 | Breast Cancer Res. Treat. | pmid:19653095 |
| Cao P et al. | Effect of green tea catechins and hydrolyzable tannins on benzo[a]pyrene-induced DNA adducts and structure-activity relationship. | 2010 | Chem. Res. Toxicol. | pmid:20218540 |
| Ueda M et al. | Tea catechins modulate the glucose transport system in 3T3-L1 adipocytes. | 2010 | Food Funct | pmid:21776468 |
| Castro J et al. | Determination of catechins and caffeine in proposed green tea standard reference materials by liquid chromatography-particle beam/electron ionization mass spectrometry (LC-PB/EIMS). | 2010 | Talanta | pmid:20875564 |
| Sánchez JC et al. | 1,1-Diphenyl-2-picrylhydrazyl radical and superoxide anion scavenging activity of Rhizophora mangle (L.) bark. | 2010 | Pharmacognosy Res | pmid:21589751 |
| Kim JH et al. | Effects of cellulase from Aspergillus niger and solvent pretreatments on the extractability of organic green tea waste. | 2010 | J. Agric. Food Chem. | pmid:20843026 |
| Sivam AS et al. | Properties of bread dough with added fiber polysaccharides and phenolic antioxidants: a review. | 2010 | J. Food Sci. | pmid:21535512 |
| Del Rio D et al. | Bioavailability and catabolism of green tea flavan-3-ols in humans. | 2010 Nov-Dec | Nutrition | pmid:20080030 |
| Qaâdan F et al. | Polyphenols from Ginkgo biloba. | 2010 Oct-Dec | Sci Pharm | pmid:21179324 |
| Ras RT et al. | Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis. | 2011 | PLoS ONE | pmid:21394199 |
| Khalifé S and Zafarullah M | Molecular targets of natural health products in arthritis. | 2011 | Arthritis Res. Ther. | pmid:21345249 |
| Javed T et al. | In-vitro antiviral activity of Solanum nigrum against Hepatitis C Virus. | 2011 | Virol. J. | pmid:21247464 |
| Maeda-Yamamoto M et al. | Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study. | 2011 | Cytotechnology | pmid:21207145 |
| Multhoff G et al. | Chronic inflammation in cancer development. | 2011 | Front Immunol | pmid:22566887 |
| Kim JA et al. | New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21489793 |
| Matsuda H et al. | Structural requirements of flavonoids for the adipogenesis of 3T3-L1 cells. | 2011 | Bioorg. Med. Chem. | pmid:21493073 |
| Kadoma Y and Fujisawa S | Radical-scavenging activity of dietary phytophenols in combination with co-antioxidants using the induction period method. | 2011 | Molecules | pmid:22173338 |
| Tachibana H | Green tea polyphenol sensing. | 2011 | Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. | pmid:21422740 |
| Yang H et al. | Characterization of unusual proanthocyanidins in leaves of bayberry ( Myrica rubra Sieb. et Zucc.). | 2011 | J. Agric. Food Chem. | pmid:21319804 |
| RodrÃguez-Durán LV et al. | Novel strategies for upstream and downstream processing of tannin acyl hydrolase. | 2011 | Enzyme Res | pmid:21941633 |
| Gavrilova V et al. | Separation, characterization and quantification of phenolic compounds in blueberries and red and black currants by HPLC-DAD-ESI-MSn. | 2011 | J. Agric. Food Chem. | pmid:21401099 |
| Yang Y et al. | Effects of some common food constituents on cardiovascular disease. | 2011 | ISRN Cardiol | pmid:22347642 |
| Arola-Arnal A and Bladé C | Proanthocyanidins modulate microRNA expression in human HepG2 cells. | 2011 | PLoS ONE | pmid:21998738 |
| Narukawa M et al. | Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21272567 |
| Jiang Y et al. | Immunoregulatory and anti-HIV-1 enzyme activities of antioxidant components from lotus (Nelumbo nucifera Gaertn.) rhizome. | 2011 | Biosci. Rep. | pmid:21114474 |
| Chandrasekara N and Shahidi F | Effect of roasting on phenolic content and antioxidant activities of whole cashew nuts, kernels, and testa. | 2011 | J. Agric. Food Chem. | pmid:21438525 |
| Singh T and Katiyar SK | Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition. | 2011 | PLoS ONE | pmid:22022384 |
| Kim Y et al. | The impact of packaging materials on the antioxidant phytochemical stability of aqueous infusions of green tea (Camellia sinensis) and yaupon holly (Ilex vomitoria) during cold storage. | 2011 | J. Agric. Food Chem. | pmid:21434687 |
| Herges K et al. | Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation. | 2011 | PLoS ONE | pmid:22022398 |
| Lv L et al. | Genistein inhibits advanced glycation end product formation by trapping methylglyoxal. | 2011 | Chem. Res. Toxicol. | pmid:21344933 |
| Riccio P et al. | May diet and dietary supplements improve the wellness of multiple sclerosis patients? A molecular approach. | 2011 | Autoimmune Dis | pmid:21461338 |
| Fujimura Y et al. | Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars. | 2011 | PLoS ONE | pmid:21853132 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Ali MB et al. | Berry skin development in Norton grape: distinct patterns of transcriptional regulation and flavonoid biosynthesis. | 2011 | BMC Plant Biol. | pmid:21219654 |
| Qa'dan F et al. | Proanthocyanidins from Ginkgo biloba leaf extract and their radical scavenging activity. | 2011 | Pharm Biol | pmid:21388236 |
| Kylli P et al. | Lingonberry (Vaccinium vitis-idaea) and European cranberry (Vaccinium microcarpon) proanthocyanidins: isolation, identification, and bioactivities. | 2011 | J. Agric. Food Chem. | pmid:21370878 |
| Sanna V et al. | Targeted biocompatible nanoparticles for the delivery of (-)-epigallocatechin 3-gallate to prostate cancer cells. | 2011 | J. Med. Chem. | pmid:21306166 |
| Pękal A et al. | Evaluation of the antioxidant properties of fruit and flavoured black teas. | 2011 | Eur J Nutr | pmid:21360165 |
| Wang SC et al. | Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3γ in an Experimental Animal Model. | 2011 | Evid Based Complement Alternat Med | pmid:19965962 |
| Wagner AE et al. | Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2. | 2011 | BMC Complement Altern Med | pmid:21199573 |
| Ankolekar C et al. | Inhibitory potential of tea polyphenolics and influence of extraction time against Helicobacter pylori and lack of inhibition of beneficial lactic acid bacteria. | 2011 | J Med Food | pmid:21663484 |
| Terra X et al. | Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes. | 2011 | Free Radic. Res. | pmid:21405989 |
| Lee YS et al. | Inhibitory effect of glucodistylin from the bark of Quercus acutissima on human recombinant aldose reductase and sorbitol accumulation. | 2011 | Arch. Pharm. Res. | pmid:21380803 |
| Hu Y et al. | Bioactive components from the tea polyphenols influence on endogenous antioxidant defense system and modulate inflammatory cytokines after total-body irradiation in mice. | 2011 | Phytomedicine | pmid:21498061 |
| Chuu CP et al. | Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer. | 2011 | J. Biomed. Sci. | pmid:21859492 |
| Maruyama T et al. | Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. | 2011 | Arch. Oral Biol. | pmid:20869695 |
| Ishii T et al. | Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21228463 |
| Monobe M et al. | Increased plasma concentration of epigallocatechin in mice after orally administering a green tea (Camellia sinensis L.) extract supplemented by steamed rice. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21228465 |
| Thakur D et al. | Antimicrobial activities of tocklai vegetative tea clones. | 2011 | Indian J. Microbiol. | pmid:23024406 |
| Wu KM et al. | Green tea extract-induced lethal toxicity in fasted but not in nonfasted dogs. | 2011 | Int. J. Toxicol. | pmid:21098339 |
| Stingl JC et al. | Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. | 2011 | BMC Cancer | pmid:21851602 |
| Braicu C et al. | The relationships between biological activities and structure of flavan-3-ols. | 2011 | Int J Mol Sci | pmid:22272136 |
| Sung JH et al. | The anti-obesity effect of Lethariella cladonioides in 3T3-L1 cells and obese mice. | 2011 | Nutr Res Pract | pmid:22259674 |
| Mannion C et al. | Components of an anticancer diet: dietary recommendations, restrictions and supplements of the Bill Henderson Protocol. | 2011 | Nutrients | pmid:22254073 |
| Chan EW et al. | Antioxidant and antibacterial properties of green, black, and herbal teas of Camellia sinensis. | 2011 | Pharmacognosy Res | pmid:22224051 |
| Manalo DJ et al. | Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22138393 |
| Petraglia AL et al. | Stuck at the bench: Potential natural neuroprotective compounds for concussion. | 2011 | Surg Neurol Int | pmid:22059141 |
| Horáková L | Flavonoids in prevention of diseases with respect to modulation of Ca-pump function. | 2011 | Interdiscip Toxicol | pmid:22058652 |
| Atawodi SE | Nigerian foodstuffs with prostate cancer chemopreventive polyphenols. | 2011 | Infect. Agents Cancer | pmid:21992488 |
| Ingólfsson HI et al. | Effects of green tea catechins on gramicidin channel function and inferred changes in bilayer properties. | 2011 | FEBS Lett. | pmid:21896274 |
| Wisuitiprot W et al. | A novel technique for chitosan microparticle preparation using a water/silicone emulsion: green tea model. | 2011 | Int J Cosmet Sci | pmid:21323933 |
| Zheng R et al. | A comparative reverse docking strategy to identify potential antineoplastic targets of tea functional components and binding mode. | 2011 | Int J Mol Sci | pmid:21954353 |
| Mukai K et al. | Kinetic study of the quenching reaction of singlet oxygen by Pyrroloquinolinequinol (PQQH(2), a reduced form of Pyrroloquinolinequinone) in micellar solution. | 2011 | J. Agric. Food Chem. | pmid:21309575 |
| Derdemezis CS et al. | Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes. | 2011 | Biochem Res Int | pmid:21949907 |
| Tanaka T et al. | Pathobiology and chemoprevention of bladder cancer. | 2011 | J Oncol | pmid:21941546 |
| Rahman S et al. | In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines. | 2011 | BMC Complement Altern Med | pmid:21933433 |
| Li Y et al. | Epigenetic regulation of caloric restriction in aging. | 2011 | BMC Med | pmid:21867551 |
| Katiyar SK and Raman C | Green tea: a new option for the prevention or control of osteoarthritis. | 2011 | Arthritis Res. Ther. | pmid:21861859 |