(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Opare Kennedy D et al. | Growth inhibitory effect of green tea extract and (-)-epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases. | 2001 | Chem. Biol. Interact. | pmid:11311209 |
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| Katiyar SK and Elmets CA | Green tea polyphenolic antioxidants and skin photoprotection (Review). | 2001 | Int. J. Oncol. | pmid:11351267 |
| Smith DM and Dou QP | Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis. | 2001 | Int. J. Mol. Med. | pmid:11351279 |
| Meng X et al. | Formation and identification of 4'-O-methyl-(-)-epigallocatechin in humans. | 2001 | Drug Metab. Dispos. | pmid:11353745 |
| Fujimura Y et al. | A tea catechin suppresses the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells. | 2001 | J. Agric. Food Chem. | pmid:11368631 |
| Bertoldi M et al. | Green tea polyphenols: novel irreversible inhibitors of dopa decarboxylase. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11374875 |
| Beppu M et al. | Water-soluble antioxidants inhibit macrophage recognition of oxidized erythrocytes. | 2001 | Biol. Pharm. Bull. | pmid:11379784 |
| Warden BA et al. | Catechins are bioavailable in men and women drinking black tea throughout the day. | 2001 | J. Nutr. | pmid:11385060 |
| Li C et al. | Analysis of urinary metabolites of tea catechins by liquid chromatography/electrospray ionization mass spectrometry. | 2001 | Chem. Res. Toxicol. | pmid:11409941 |
| Muto S et al. | Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450. | 2001 | Mutat. Res. | pmid:11470492 |
| Anderson RF et al. | Green tea catechins partially protect DNA from (.)OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals. | 2001 | Carcinogenesis | pmid:11470748 |
| Yoshioka H et al. | Spin-trapping study on the hydroxyl radical formed from a tea catechin-Cu(II) system. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11577706 |
| Hong J et al. | Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. | 2001 | Biochem. Pharmacol. | pmid:11705450 |
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| Jin CF et al. | Different effects of five catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. | 2001 | J. Agric. Food Chem. | pmid:11743804 |
| Nie G et al. | Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. | 2002 | Arch. Biochem. Biophys. | pmid:11747313 |
| Inoue MB et al. | Potentiometric and (1)H NMR studies of complexation of Al(3+) with (-)-epigallocatechin gallate, a major active constituent of green tea. | 2002 | J. Inorg. Biochem. | pmid:11750019 |
| Locher R et al. | Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. | 2002 | Eur. J. Pharmacol. | pmid:11755158 |
| Bhatia N et al. | Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. | 2001 | Nutr Cancer | pmid:11759294 |
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| Annabi B et al. | Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. | 2002 | Biochim. Biophys. Acta | pmid:11853893 |
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