(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Farhan M et al. | Mobilization of copper ions in human peripheral lymphocytes by catechins leading to oxidative DNA breakage: A structure activity study. | 2015 | Arch. Biochem. Biophys. | pmid:26142371 |
| Takagaki A et al. | Isolation and characterization of rat intestinal bacteria involved in biotransformation of (-)-epigallocatechin. | 2014 | Arch. Microbiol. | pmid:24947740 |
| Narotzki B et al. | Green tea: a promising natural product in oral health. | 2012 | Arch. Oral Biol. | pmid:22226360 |
| Maruyama T et al. | Supplementation of green tea catechins in dentifrices suppresses gingival oxidative stress and periodontal inflammation. | 2011 | Arch. Oral Biol. | pmid:20869695 |
| Lyu SY and Park WB | Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. | 2005 | Arch. Pharm. Res. | pmid:15974445 |
| Lee YS et al. | Inhibitory effect of glucodistylin from the bark of Quercus acutissima on human recombinant aldose reductase and sorbitol accumulation. | 2011 | Arch. Pharm. Res. | pmid:21380803 |
| Han DH and Kim JH | Difference in growth suppression and apoptosis induction of EGCG and EGC on human promyelocytic leukemia HL-60 cells. | 2009 | Arch. Pharm. Res. | pmid:19407972 |
| Ozcan A et al. | Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced cystitis in rats. | 2005 | Arch. Toxicol. | pmid:15800758 |
| Khalifé S and Zafarullah M | Molecular targets of natural health products in arthritis. | 2011 | Arthritis Res. Ther. | pmid:21345249 |
| Ahmed S | Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise. | 2010 | Arthritis Res. Ther. | pmid:20447316 |
| Katiyar SK and Raman C | Green tea: a new option for the prevention or control of osteoarthritis. | 2011 | Arthritis Res. Ther. | pmid:21861859 |
| Maeda K et al. | Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier. | 2003 | Atherosclerosis | pmid:12482547 |
| Riccio P et al. | May diet and dietary supplements improve the wellness of multiple sclerosis patients? A molecular approach. | 2011 | Autoimmune Dis | pmid:21461338 |
| Hisamura F et al. | Protective effect of green tea extract and tea polyphenols against FK506-induced cytotoxicity in renal cells. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16445594 |
| Wang CJ et al. | (-)-epigallocatechin gallate inhibits endothelin-1-induced C-reactive protein production in vascular smooth muscle cells. | 2010 | Basic Clin. Pharmacol. Toxicol. | pmid:20346058 |
| Derdemezis CS et al. | Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes. | 2011 | Biochem Res Int | pmid:21949907 |
| Ludwig A et al. | The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15033450 |
| Park BJ et al. | Antifungal susceptibility of epigallocatechin 3-O-gallate (EGCg) on clinical isolates of pathogenic yeasts. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16831406 |
| Long LH et al. | Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10873562 |
| Abe I et al. | Green tea polyphenols: novel and potent inhibitors of squalene epoxidase. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679280 |