(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bindon KA and Smith PA | Comparison of the affinity and selectivity of insoluble fibres and commercial proteins for wine proanthocyanidins. | 2013 | Food Chem | pmid:23122145 |
| Ghosh S et al. | (-)-Epicatechin gallate prevents alkali-salt mediated fibrillogenesis of hen egg white lysozyme. | 2013 | Int. J. Biol. Macromol. | pmid:23219698 |
| Roy S et al. | Combination therapy of dexamethasone with epigallocatechin enhances tibiotarsal bone articulation and modulates oxidative status correlates with cartilage cytokines expression in the early phase of experimental arthritis. | 2013 | Eur. J. Pharmacol. | pmid:23183110 |
| Koga K et al. | Proanthocyanidin oligomers isolated from Salacia reticulata leaves potently inhibit pancreatic lipase activity. | 2013 | J. Food Sci. | pmid:23278351 |
| Cudmore MJ et al. | Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1. | 2012 | Eur. Heart J. | pmid:21411816 |
| Lee YJ et al. | Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. | 2012 | J Neuroinflammation | pmid:22339795 |
| Yano T et al. | Unified approach to catechin hetero-oligomers: first total synthesis of trimer EZ-EG-CA isolated from Ziziphus jujuba. | 2012 | Org. Biomol. Chem. | pmid:22930202 |
| Arimboor R and Arumughan C | Effect of polymerization on antioxidant and xanthine oxidase inhibitory potential of sea buckthorn (H. rhamnoides) proanthocyanidins. | 2012 | J. Food Sci. | pmid:22938149 |
| Xiao JS et al. | Characterization of oligomeric procyanidins and identification of quercetin glucuronide from lotus ( Nelumbo nucifera Gaertn.) seedpod. | 2012 | J. Agric. Food Chem. | pmid:22369273 |
| Ikeda H et al. | Incompatibility between propericiazine oral solution and tea-based drink. | 2012 | Chem. Pharm. Bull. | pmid:22976331 |
| Zhou YB et al. | Polyphenol content of plasma and litter after the oral administration of green tea and tea polyphenols in chickens. | 2012 | J. Agric. Food Chem. | pmid:22224899 |
| Ikeda H et al. | [Mechanism of interaction between risperidone and tea catechin (2) influence of presence of galloyl group in catechin on insoluble complex formation with risperidone]. | 2012 | Yakugaku Zasshi | pmid:22214589 |
| Lee YH et al. | EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity. | 2012 | Int. J. Mol. Med. | pmid:22505206 |
| Roy S et al. | A novel combination of methotrexate and epigallocatechin attenuates the overexpression of pro-inflammatory cartilage cytokines and modulates antioxidant status in adjuvant arthritic rats. | 2012 | Inflammation | pmid:22453361 |
| Wang H et al. | Profiles and α-amylase inhibition activity of proanthocyanidins in unripe Manilkara zapota (chiku). | 2012 | J. Agric. Food Chem. | pmid:22394060 |
| Sasaki T et al. | Green tea catechins increase the force of contraction in isolated guinea pig atrial muscle preparations by increasing the amplitude of intracellular Ca2+ concentration. | 2012 | J. Vet. Med. Sci. | pmid:22864409 |
| Li D et al. | Development of an isocratic HPLC method for catechin quantification and its application to formulation studies. | 2012 | Fitoterapia | pmid:22735602 |
| Unno T et al. | Gallated form of tea catechin, not nongallated form, increases fecal starch excretion in rats. | 2012 | J. Nutr. Sci. Vitaminol. | pmid:23007066 |
| Delcambre A and Saucier C | Identification of new flavan-3-ol monoglycosides by UHPLC-ESI-Q-TOF in grapes and wine. | 2012 | J Mass Spectrom | pmid:22707165 |
| Jaiswal R et al. | Identification and characterization of proanthocyanidins of 16 members of the Rhododendron genus (Ericaceae) by tandem LC-MS. | 2012 | J Mass Spectrom | pmid:22689627 |
| Bustos I et al. | Effect of flavan-3-ols on the adhesion of potential probiotic lactobacilli to intestinal cells. | 2012 | J. Agric. Food Chem. | pmid:22889010 |
| Theisen LL and Muller CP | EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo. | 2012 | Antiviral Res. | pmid:22475498 |
| Ghiringhelli F et al. | Immunomodulation and anti-inflammatory roles of polyphenols as anticancer agents. | 2012 | Anticancer Agents Med Chem | pmid:22292769 |
| Al-Rejaie SS et al. | Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats. | 2012 | Lipids Health Dis | pmid:22423898 |
| Stef DS and Gergen I | Effect of mineral-enriched diet and medicinal herbs on Fe, Mn, Zn, and Cu uptake in chicken. | 2012 | Chem Cent J | pmid:22429523 |
| Li G et al. | A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22178739 |
| Apak R et al. | Selective determination of catechin among phenolic antioxidants with the use of a novel optical fiber reflectance sensor based on indophenol dye formation on nano-sized TiOâ‚‚. | 2012 | J. Agric. Food Chem. | pmid:22339278 |
| Maeda-Yamamoto M et al. | Epicatechin-3-O-(3″-O-methyl)-gallate content in various tea cultivars (Camellia sinensis L.) and its in vitro inhibitory effect on histamine release. | 2012 | J. Agric. Food Chem. | pmid:22339247 |
| Manir MM et al. | Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase. | 2012 | Bioorg. Med. Chem. | pmid:22377672 |
| Huang YF et al. | Dissecting genetic architecture of grape proanthocyanidin composition through quantitative trait locus mapping. | 2012 | BMC Plant Biol. | pmid:22369244 |
| Miller RJ et al. | A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins. | 2012 | Eur J Nutr | pmid:21445620 |
| Dinicola S et al. | Antiproliferative and apoptotic effects triggered by Grape Seed Extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines. | 2012 | Int J Mol Sci | pmid:22312277 |
| Yokozawa T et al. | Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress. | 2012 | Evid Based Complement Alternat Med | pmid:22844338 |
| Vodnar DC and Socaciu C | Green tea increases the survival yield of Bifidobacteria in simulated gastrointestinal environment and during refrigerated conditions. | 2012 | Chem Cent J | pmid:22727242 |
| Yamashita A et al. | Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia. | 2012 | Mar Drugs | pmid:22690141 |
| Davalli P et al. | Anticancer activity of green tea polyphenols in prostate gland. | 2012 | Oxid Med Cell Longev | pmid:22666523 |
| Grabber JH et al. | Identifying new lignin bioengineering targets: impact of epicatechin, quercetin glycoside, and gallate derivatives on the lignification and fermentation of maize cell walls. | 2012 | J. Agric. Food Chem. | pmid:22475000 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Luo ZM et al. | A new norisoprenoid and other compounds from Fuzhuan brick tea. | 2012 | Molecules | pmid:22430120 |
| Berindan-Neagoe I et al. | Early apoptosis signals induced by a low dose of epigallocatechin 3-gallate interfere with apoptotic and cell death pathways. | 2012 | J Nanosci Nanotechnol | pmid:22755028 |
| Blaylock RL and Maroon J | Natural plant products and extracts that reduce immunoexcitotoxicity-associated neurodegeneration and promote repair within the central nervous system. | 2012 | Surg Neurol Int | pmid:22439110 |
| Yang YJ et al. | Dietary flavan-3-ols intake and metabolic syndrome risk in Korean adults. | 2012 | Nutr Res Pract | pmid:22413043 |
| Choi SK et al. | Suppression of oxidative stress by grape seed supplementation in rats. | 2012 | Nutr Res Pract | pmid:22413034 |
| Matsumoto Y et al. | Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate. | 2012 | Front Microbiol | pmid:22355295 |
| Ortsäter H et al. | Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. | 2012 | Nutr Metab (Lond) | pmid:22333133 |
| Kim DY et al. | Boesenbergia pandurata attenuates diet-induced obesity by activating AMP-activated protein kinase and regulating lipid metabolism. | 2012 | Int J Mol Sci | pmid:22312299 |
| Gordon MH | Significance of dietary antioxidants for health. | 2012 | Int J Mol Sci | pmid:22312245 |
| Campbell BC et al. | Chemosensitization as a means to augment commercial antifungal agents. | 2012 | Front Microbiol | pmid:22393330 |
| Huang WY et al. | Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. | 2012 | J Zhejiang Univ Sci B | pmid:22302422 |
| Baumeister P et al. | Curcumin and other polyphenolic compounds in head and neck cancer chemoprevention. | 2012 | Oxid Med Cell Longev | pmid:22690273 |