(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ludwig A et al. | The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15033450 |
| Long LH and Halliwell B | The effects of oxaloacetate on hydrogen peroxide generation from ascorbate and epigallocatechin gallate in cell culture media: potential for altering cell metabolism. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22166196 |
| Narukawa M et al. | Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21272567 |
| Bertoldi M et al. | Green tea polyphenols: novel irreversible inhibitors of dopa decarboxylase. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11374875 |
| Abe I et al. | Green tea polyphenols: novel and potent inhibitors of squalene epoxidase. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679280 |
| Manalo DJ et al. | Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22138393 |
| Bain J et al. | The specificities of protein kinase inhibitors: an update. | 2003 | Biochem. J. | pmid:12534346 |
| Hong J et al. | Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. | 2001 | Biochem. Pharmacol. | pmid:11705450 |
| Chen D et al. | Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. | 2005 | Biochem. Pharmacol. | pmid:15857617 |
| Baek WK et al. | Inhibitory modulation of ATP-sensitive potassium channels by gallate-ester moiety of (-)-epigallocatechin-3-gallate. | 2005 | Biochem. Pharmacol. | pmid:16216226 |
| Ochiai H et al. | Epigallocatechin-3-gallate is an inhibitor of Na+, K(+)-ATPase by favoring the E1 conformation. | 2009 | Biochem. Pharmacol. | pmid:19539611 |
| Feng W et al. | Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1). | 2010 | Biochem. Pharmacol. | pmid:20471964 |
| Miyata M et al. | The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site. | 2010 | Biochemistry | pmid:20565072 |
| Kamihira-Ishijima M et al. | Inhibitory mechanism of pancreatic amyloid fibril formation: formation of the complex between tea catechins and the fragment of residues 22-27. | 2012 | Biochemistry | pmid:23205879 |
| Nakane H and Ono K | Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases. | 1990 | Biochemistry | pmid:1693287 |
| Kong LX and Zeng CM | Effects of Seeding on Lysozyme Amyloid Fibrillation in the Presence of Epigallocatechin and Polyethylene Glycol. | 2017 | Biochemistry Mosc. | pmid:28320299 |
| Ikeda I et al. | Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats. | 1992 | Biochim. Biophys. Acta | pmid:1643098 |
| Annabi B et al. | Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. | 2002 | Biochim. Biophys. Acta | pmid:11853893 |
| Mochizuki M et al. | Kinetic analysis and mechanistic aspects of autoxidation of catechins. | 2002 | Biochim. Biophys. Acta | pmid:11853955 |
| Sugita-Konishi Y et al. | Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of Vero toxin from enterohemorrhagic Escherichia coli O157:H7. | 1999 | Biochim. Biophys. Acta | pmid:10572924 |