(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jin CF et al. | Different effects of five catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. | 2001 | J. Agric. Food Chem. | pmid:11743804 |
| Nie G et al. | Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. | 2002 | Arch. Biochem. Biophys. | pmid:11747313 |
| Inoue MB et al. | Potentiometric and (1)H NMR studies of complexation of Al(3+) with (-)-epigallocatechin gallate, a major active constituent of green tea. | 2002 | J. Inorg. Biochem. | pmid:11750019 |
| Locher R et al. | Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. | 2002 | Eur. J. Pharmacol. | pmid:11755158 |
| Bhatia N et al. | Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. | 2001 | Nutr Cancer | pmid:11759294 |
| Wang LQ et al. | The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium. | 2001 | Chem. Pharm. Bull. | pmid:11767089 |
| Zhu BT et al. | Rapid conversion of tea catechins to monomethylated products by rat liver cytosolic catechol-O-methyltransferase. | 2001 | Xenobiotica | pmid:11780762 |
| Van Amelsvoort JM et al. | Plasma concentrations of individual tea catechins after a single oral dose in humans. | 2001 | Xenobiotica | pmid:11780763 |
| Kang HW et al. | Isolation and characterization of alkyl peroxy radical scavenging compound from leaves of Laurus nobilis. | 2002 | Biol. Pharm. Bull. | pmid:11824536 |
| Furuno K et al. | The contribution of the pyrogallol moiety to the superoxide radical scavenging activity of flavonoids. | 2002 | Biol. Pharm. Bull. | pmid:11824550 |
| Tillekeratne LM et al. | Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11844664 |
| Kandil FE et al. | Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. | 2002 | J. Agric. Food Chem. | pmid:11853481 |
| Annabi B et al. | Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. | 2002 | Biochim. Biophys. Acta | pmid:11853893 |
| Mochizuki M et al. | Kinetic analysis and mechanistic aspects of autoxidation of catechins. | 2002 | Biochim. Biophys. Acta | pmid:11853955 |
| Luo XD et al. | Polyphenolic antioxidants from the fruits of Chrysophyllum cainito L. (Star Apple). | 2002 | J. Agric. Food Chem. | pmid:11879006 |
| Kennedy DO et al. | Cellular thiol status-dependent inhibition of tumor cell growth via modulation of retinoblastoma protein phosphorylation by (-)-epigallocatechin. | 2002 | Cancer Lett. | pmid:11880178 |
| Fernández PL et al. | Study of catechin and xanthine tea profiles as geographical tracers. | 2002 | J. Agric. Food Chem. | pmid:11902920 |
| Tanaka T et al. | Synthesis of theaflavin from epicatechin and epigallocatechin by plant homogenates and role of epicatechin quinone in the synthesis and degradation of theaflavin. | 2002 | J. Agric. Food Chem. | pmid:11902970 |
| Dhawan A et al. | Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. | 2002 | Mutat. Res. | pmid:11909753 |
| Carini M et al. | Antioxidant and photoprotective activity of a lipophilic extract containing neolignans from Krameria triandra roots. | 2002 | Planta Med. | pmid:11914952 |