(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kinjo J et al. | Activity-guided fractionation of green tea extract with antiproliferative activity against human stomach cancer cells. | 2002 | Biol. Pharm. Bull. | pmid:12230128 |
| Cantos E et al. | Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. | 2002 | J. Agric. Food Chem. | pmid:12236700 |
| Sanae F et al. | Effects of catechins on vascular tone in rat thoracic aorta with endothelium. | 2002 | Life Sci. | pmid:12270760 |
| Turner ND et al. | Opportunities for nutritional amelioration of radiation-induced cellular damage. | 2002 | Nutrition | pmid:12361786 |
| Lin SC et al. | Regulation of IGFBP-5 expression during tumourigenesis and differentiation of oral keratinocytes. | 2002 | J. Pathol. | pmid:12375264 |
| Lee MJ et al. | Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12376503 |
| Cai Y et al. | Contribution of presystemic hepatic extraction to the low oral bioavailability of green tea catechins in rats. | 2002 | Drug Metab. Dispos. | pmid:12386131 |
| Choi JY et al. | Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate. | 2002 | Neurotoxicology | pmid:12387363 |
| Nakagawa T and Yokozawa T | Direct scavenging of nitric oxide and superoxide by green tea. | 2002 | Food Chem. Toxicol. | pmid:12419687 |
| Cai YJ et al. | Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes. | 2002 | Chem. Phys. Lipids | pmid:12426080 |
| Saito M et al. | Green tea polyphenols inhibit metalloproteinase activities in the skin, muscle, and blood of rainbow trout. | 2002 | J. Agric. Food Chem. | pmid:12428978 |
| Anderson RA and Polansky MM | Tea enhances insulin activity. | 2002 | J. Agric. Food Chem. | pmid:12428980 |
| Tanaka T et al. | Accumulation of epigallocatechin quinone dimers during tea fermentation and formation of theasinensins. | 2002 | J. Nat. Prod. | pmid:12444680 |
| Vergote D et al. | (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. | 2002 | Breast Cancer Res. Treat. | pmid:12462380 |
| González de MejÃa E et al. | Topoisomerase I and II enzyme inhibitory aqueous extract of Ardisia compressa and ardisin protect against benomyl oxidation of hepatocytes. | 2002 | J. Agric. Food Chem. | pmid:12475294 |
| Maeda K et al. | Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier. | 2003 | Atherosclerosis | pmid:12482547 |
| Kajiya K et al. | Effects of external factors on the interaction of tea catechins with lipid bilayers. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12506968 |
| Suzuki M et al. | Epimerization of tea catechins and O-methylated derivatives of (-)-epigallocatechin-3-O-gallate: relationship between epimerization and chemical structure. | 2003 | J. Agric. Food Chem. | pmid:12517118 |
| Bain J et al. | The specificities of protein kinase inhibitors: an update. | 2003 | Biochem. J. | pmid:12534346 |
| Shen JZ et al. | Green tea catechins evoke a phasic contraction in rat aorta via H2O2-mediated multiple-signalling pathways. | Clin. Exp. Pharmacol. Physiol. | pmid:12542460 |