9-HODE

9-hode is a lipid of Fatty Acyls (FA) class. 9-hode is associated with abnormalities such as Atherosclerosis, Chronic disease and Rheumatoid Arthritis. The involved functions are known as Oxidation, Transcriptional Activation, Esthesia, Signal Transduction and Process. 9-hode often locates in viral nucleocapsid location, Blood, Body tissue, Protoplasm and Lysosomal. The associated genes with 9-HODE are CD1A gene, CD276 Antigen, CD14 gene, IMPACT gene and GPR132 gene. The related lipids are Fatty Acids, 9-hydroxy-10,12-octadecadienoic acid, Nonesterified Fatty Acids, octadecadienoic acid and Total cholesterol.

Cross Reference

Introduction

To understand associated biological information of 9-HODE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 9-HODE?

9-HODE is suspected in Atherosclerosis, Chronic disease, Rheumatoid Arthritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 9-HODE

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Familial Mediterranean Fever D010505 12 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with 9-HODE

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 9-HODE through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 9-HODE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 9-HODE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 9-HODE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 9-HODE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 9-HODE?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 9-HODE

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Authors Title Published Journal PubMed Link
Zhao T et al. Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis. 2016 Oncotarget pmid:26625314
Zha K et al. LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation. 2015 Lipids Health Dis pmid:26302822
Rolin J and Maghazachi AA Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. 2014 J. Leukoc. Biol. pmid:24493826
Nieman DC et al. Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24760997
Yuan ZX et al. Identification and profiling of targeted oxidized linoleic acid metabolites in rat plasma by quadrupole time-of-flight mass spectrometry. 2013 Biomed. Chromatogr. pmid:23037960
Alsalem M et al. The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms. 2013 Br. J. Pharmacol. pmid:23278358
Nalam VJ et al. The green peach aphid, Myzus persicae, acquires a LIPOXYGENASE5-derived oxylipin from Arabidopsis thaliana, which promotes colonization of the host plant. 2013 Plant Signal Behav pmid:23221749
Garbin U et al. Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids? 2013 Cardiovasc. Res. pmid:22997156
Niculescu LS et al. HDL inhibits endoplasmic reticulum stress by stimulating apoE and CETP secretion from lipid-loaded macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23537656
Garofalo JM et al. Mouse mammary gland is refractory to the effects of ethanol after natural lactation. 2013 Comp. Med. pmid:23561936