MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Familial Mediterranean Fever | D010505 | 12 associated lipids |
9-hode is a lipid of Fatty Acyls (FA) class. 9-hode is associated with abnormalities such as Atherosclerosis, Chronic disease and Rheumatoid Arthritis. The involved functions are known as Oxidation, Transcriptional Activation, Esthesia, Signal Transduction and Process. 9-hode often locates in viral nucleocapsid location, Blood, Body tissue, Protoplasm and Lysosomal. The associated genes with 9-HODE are CD1A gene, CD276 Antigen, CD14 gene, IMPACT gene and GPR132 gene. The related lipids are Fatty Acids, 9-hydroxy-10,12-octadecadienoic acid, Nonesterified Fatty Acids, octadecadienoic acid and Total cholesterol.
To understand associated biological information of 9-HODE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
9-HODE is suspected in Atherosclerosis, Chronic disease, Rheumatoid Arthritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 9-HODE
MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Familial Mediterranean Fever | D010505 | 12 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 9-HODE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Zhao T et al. | Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis. | 2016 | Oncotarget | pmid:26625314 |
Zha K et al. | LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation. | 2015 | Lipids Health Dis | pmid:26302822 |
Rolin J and Maghazachi AA | Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. | 2014 | J. Leukoc. Biol. | pmid:24493826 |
Nieman DC et al. | Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24760997 |
Yuan ZX et al. | Identification and profiling of targeted oxidized linoleic acid metabolites in rat plasma by quadrupole time-of-flight mass spectrometry. | 2013 | Biomed. Chromatogr. | pmid:23037960 |
Alsalem M et al. | The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms. | 2013 | Br. J. Pharmacol. | pmid:23278358 |
Nalam VJ et al. | The green peach aphid, Myzus persicae, acquires a LIPOXYGENASE5-derived oxylipin from Arabidopsis thaliana, which promotes colonization of the host plant. | 2013 | Plant Signal Behav | pmid:23221749 |
Garbin U et al. | Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids? | 2013 | Cardiovasc. Res. | pmid:22997156 |
Niculescu LS et al. | HDL inhibits endoplasmic reticulum stress by stimulating apoE and CETP secretion from lipid-loaded macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23537656 |
Garofalo JM et al. | Mouse mammary gland is refractory to the effects of ethanol after natural lactation. | 2013 | Comp. Med. | pmid:23561936 |