MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
Familial Mediterranean Fever | D010505 | 12 associated lipids |
9-hode is a lipid of Fatty Acyls (FA) class. 9-hode is associated with abnormalities such as Atherosclerosis, Chronic disease and Rheumatoid Arthritis. The involved functions are known as Oxidation, Transcriptional Activation, Esthesia, Signal Transduction and Process. 9-hode often locates in viral nucleocapsid location, Blood, Body tissue, Protoplasm and Lysosomal. The associated genes with 9-HODE are CD1A gene, CD276 Antigen, CD14 gene, IMPACT gene and GPR132 gene. The related lipids are Fatty Acids, 9-hydroxy-10,12-octadecadienoic acid, Nonesterified Fatty Acids, octadecadienoic acid and Total cholesterol.
To understand associated biological information of 9-HODE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
9-HODE is suspected in Atherosclerosis, Chronic disease, Rheumatoid Arthritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 9-HODE
MeSH term | MeSH ID | Detail |
---|---|---|
Body Weight | D001835 | 333 associated lipids |
Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
Familial Mediterranean Fever | D010505 | 12 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 9-HODE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ramsden CE et al. | Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959954 |
Pollack AZ et al. | Relation of blood cadmium, lead, and mercury levels to biomarkers of lipid peroxidation in premenopausal women. | 2012 | Am. J. Epidemiol. | pmid:22302120 |
Yuki K et al. | Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22790953 |
De Petrocellis L et al. | A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons. | 2012 | Br. J. Pharmacol. | pmid:22861649 |
Ruparel S et al. | The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. | 2012 | Mol Pain | pmid:23006841 |
Gaskins AJ et al. | Adherence to a Mediterranean diet and plasma concentrations of lipid peroxidation in premenopausal women. | 2010 | Am. J. Clin. Nutr. | pmid:20943796 |
Ogawa A et al. | Identification and analysis of two splice variants of human G2A generated by alternative splicing. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19855098 |
Liu W et al. | Ex vivo oxidation in tissue and plasma assays of hydroxyoctadecadienoates: Z,E/E,E stereoisomer ratios. | 2010 | Chem. Res. Toxicol. | pmid:20423158 |
Imaizumi S et al. | L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. | 2010 | Drug Metab Lett | pmid:20642447 |
Kawakami Y et al. | Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. | 2009 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19457650 |