MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Familial Mediterranean Fever | D010505 | 12 associated lipids |
9-hode is a lipid of Fatty Acyls (FA) class. 9-hode is associated with abnormalities such as Atherosclerosis, Chronic disease and Rheumatoid Arthritis. The involved functions are known as Oxidation, Transcriptional Activation, Esthesia, Signal Transduction and Process. 9-hode often locates in viral nucleocapsid location, Blood, Body tissue, Protoplasm and Lysosomal. The associated genes with 9-HODE are CD1A gene, CD276 Antigen, CD14 gene, IMPACT gene and GPR132 gene. The related lipids are Fatty Acids, 9-hydroxy-10,12-octadecadienoic acid, Nonesterified Fatty Acids, octadecadienoic acid and Total cholesterol.
To understand associated biological information of 9-HODE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
9-HODE is suspected in Atherosclerosis, Chronic disease, Rheumatoid Arthritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 9-HODE
MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Familial Mediterranean Fever | D010505 | 12 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 9-HODE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Bürger F et al. | Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes. | 1999 | Mol. Carcinog. | pmid:10078938 |
Inouye M et al. | Formation of 9-hydroxy linoleic acid as a product of phospholipid peroxidation in diabetic erythrocyte membranes. | 1999 | Biochim. Biophys. Acta | pmid:10320803 |
Truitt A et al. | Antiplatelet effects of conjugated linoleic acid isomers. | 1999 | Biochim. Biophys. Acta | pmid:10320806 |
Garcia-Cruset S et al. | Oxysterols in cap and core of human advanced atherosclerotic lesions. | 1999 | Free Radic. Res. | pmid:10342328 |
Sarraf P et al. | Loss-of-function mutations in PPAR gamma associated with human colon cancer. | 1999 | Mol. Cell | pmid:10394368 |
Chen NG et al. | PPARgamma agonists enhance human vascular endothelial adhesiveness by increasing ICAM-1 expression. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10512746 |
Jang MK et al. | Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10558912 |
Bürger F et al. | Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes. | 2000 | Biochem. J. | pmid:10816426 |
Han KH et al. | Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. | 2000 | J. Clin. Invest. | pmid:10995790 |