9-HODE

9-hode is a lipid of Fatty Acyls (FA) class. 9-hode is associated with abnormalities such as Atherosclerosis, Chronic disease and Rheumatoid Arthritis. The involved functions are known as Oxidation, Transcriptional Activation, Esthesia, Signal Transduction and Process. 9-hode often locates in viral nucleocapsid location, Blood, Body tissue, Protoplasm and Lysosomal. The associated genes with 9-HODE are CD1A gene, CD276 Antigen, CD14 gene, IMPACT gene and GPR132 gene. The related lipids are Fatty Acids, 9-hydroxy-10,12-octadecadienoic acid, Nonesterified Fatty Acids, octadecadienoic acid and Total cholesterol.

Cross Reference

Introduction

To understand associated biological information of 9-HODE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 9-HODE?

9-HODE is suspected in Atherosclerosis, Chronic disease, Rheumatoid Arthritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 9-HODE

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Body Weight D001835 333 associated lipids
Familial Mediterranean Fever D010505 12 associated lipids
Total 3

PubChem Associated disorders and diseases

What pathways are associated with 9-HODE

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 9-HODE through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 9-HODE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 9-HODE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 9-HODE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 9-HODE?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 9-HODE?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 9-HODE

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Authors Title Published Journal PubMed Link
Camp RD and Fincham NJ Inhibition of ionophore-stimulated leukotriene B4 production in human leucocytes by monohydroxy fatty acids. 1985 Br. J. Pharmacol. pmid:2994785
Aisen PS et al. Circulating hydroxy fatty acids in familial Mediterranean fever. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:3919389
Engels F et al. Cyclooxygenase-catalyzed formation of 9-hydroxylinoleic acid by guinea pig alveolar macrophages under non-stimulated conditions. 1986 FEBS Lett. pmid:3098580
Henry DY et al. Isolation and characterization of 9-hydroxy-10-trans,12-cis-octadecadienoic acid, a novel regulator of platelet adenylate cyclase from Glechoma hederacea L. Labiatae. 1987 Eur. J. Biochem. pmid:3691528
Nugteren DH and Kivits GA Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. 1987 Biochim. Biophys. Acta pmid:3113487
Pankonin G et al. Inhibition of cell migrations by the linoleic acid oxygenation product 9S-hydroxy 10E,12Z octadecadienoic acid (9-HODE). 1988 Biomed. Biochim. Acta pmid:3151051
Kühn H et al. Occurrence of free and esterified lipoxygenase products in leaves of Glechoma hederacea L. and other Labiatae. 1989 Eur. J. Biochem. pmid:2598926
Daret D et al. Synthesis of hydroxy fatty acids from linoleic acid by human blood platelets. 1989 Prostaglandins pmid:2505334
Kaduce TL et al. Formation of 9-hydroxyoctadecadienoic acid from linoleic acid in endothelial cells. 1989 J. Biol. Chem. pmid:2496121
Engels F et al. Modulatory activity of 9-hydroxy- and 9-hydroperoxy-octadecadienoic acid towards reactive oxygen species from guinea-pig pulmonary macrophages. 1989 Eur. J. Biochem. pmid:2550227