Dimorphecolic acid

Dimorphecolic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 404 references associated with Dimorphecolic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Dimorphecolic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dimorphecolic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Familial Mediterranean Fever D010505 12 associated lipids
Total 2

All references with Dimorphecolic acid

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Zhao T et al. Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis. 2016 Oncotarget pmid:26625314
Zha K et al. LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation. 2015 Lipids Health Dis pmid:26302822
Rolin J and Maghazachi AA Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. 2014 J. Leukoc. Biol. pmid:24493826
Nieman DC et al. Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24760997
Yuan ZX et al. Identification and profiling of targeted oxidized linoleic acid metabolites in rat plasma by quadrupole time-of-flight mass spectrometry. 2013 Biomed. Chromatogr. pmid:23037960
Alsalem M et al. The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms. 2013 Br. J. Pharmacol. pmid:23278358
Nalam VJ et al. The green peach aphid, Myzus persicae, acquires a LIPOXYGENASE5-derived oxylipin from Arabidopsis thaliana, which promotes colonization of the host plant. 2013 Plant Signal Behav pmid:23221749
Garbin U et al. Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids? 2013 Cardiovasc. Res. pmid:22997156
Niculescu LS et al. HDL inhibits endoplasmic reticulum stress by stimulating apoE and CETP secretion from lipid-loaded macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23537656
Garofalo JM et al. Mouse mammary gland is refractory to the effects of ethanol after natural lactation. 2013 Comp. Med. pmid:23561936
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Pollack AZ et al. Relation of blood cadmium, lead, and mercury levels to biomarkers of lipid peroxidation in premenopausal women. 2012 Am. J. Epidemiol. pmid:22302120
Yuki K et al. Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei. 2012 Biosci. Biotechnol. Biochem. pmid:22790953
De Petrocellis L et al. A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons. 2012 Br. J. Pharmacol. pmid:22861649
Ruparel S et al. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 2012 Mol Pain pmid:23006841
Gaskins AJ et al. Adherence to a Mediterranean diet and plasma concentrations of lipid peroxidation in premenopausal women. 2010 Am. J. Clin. Nutr. pmid:20943796
Ogawa A et al. Identification and analysis of two splice variants of human G2A generated by alternative splicing. 2010 J. Pharmacol. Exp. Ther. pmid:19855098
Liu W et al. Ex vivo oxidation in tissue and plasma assays of hydroxyoctadecadienoates: Z,E/E,E stereoisomer ratios. 2010 Chem. Res. Toxicol. pmid:20423158
Imaizumi S et al. L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. 2010 Drug Metab Lett pmid:20642447
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Yokoi H et al. Peroxisome proliferator-activated receptor gamma ligands isolated from adlay seed (Coix lacryma-jobi L. var. ma-yuen STAPF.). 2009 Biol. Pharm. Bull. pmid:19336916
Obinata H and Izumi T G2A as a receptor for oxidized free fatty acids. 2009 Prostaglandins Other Lipid Mediat. pmid:19063986
Muellner MK et al. Hydrogen sulfide destroys lipid hydroperoxides in oxidized LDL. 2009 Biochem. J. pmid:19265508
Hattori T et al. G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid. 2008 J. Invest. Dermatol. pmid:18034171
Hampel JK et al. Differential modulation of cell cycle, apoptosis and PPARgamma2 gene expression by PPARgamma agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16647253
Hübke H et al. Characterization and quantification of free and esterified 9- and 13-hydroxyoctadecadienoic acids (HODE) in barley, germinating barley, and finished malt. 2005 J. Agric. Food Chem. pmid:15740040
Kim E et al. An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis. 2005 Oncogene pmid:15558016
Obinata H et al. Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. 2005 J. Biol. Chem. pmid:16236715
Coutant F et al. Sensing environmental lipids by dendritic cell modulates its function. 2004 J. Immunol. pmid:14688309
Cahoon EB and Kinney AJ Dimorphecolic acid is synthesized by the coordinate activities of two divergent Delta12-oleic acid desaturases. 2004 J. Biol. Chem. pmid:14718523
Komaraiah P et al. Enhanced production of antimicrobial sesquiterpenes and lipoxygenase metabolites in elicitor-treated hairy root cultures of Solanum tuberosum. 2003 Biotechnol. Lett. pmid:12882150
Salomonsson L et al. Oxidised LDL decreases VEGFR-1 expression in human monocyte-derived macrophages. 2003 Atherosclerosis pmid:12921977
Fischer B et al. Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma. 2002 J. Immunol. pmid:11884452
Schild RL et al. The activity of PPAR gamma in primary human trophoblasts is enhanced by oxidized lipids. 2002 J. Clin. Endocrinol. Metab. pmid:11889173
Weichert H et al. Metabolic profiling of oxylipins in germinating cucumber seedlings--lipoxygenase-dependent degradation of triacylglycerols and biosynthesis of volatile aldehydes. 2002 Planta pmid:12172844
Dandona P et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. 2001 J. Clin. Endocrinol. Metab. pmid:11232024
Aljada A et al. Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action? 2001 J. Clin. Endocrinol. Metab. pmid:11443197
Jisaka M et al. Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine. 2001 Arch. Biochem. Biophys. pmid:11368335
Aljada A et al. Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects. 2001 J. Clin. Endocrinol. Metab. pmid:11443177
Han KH et al. Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. 2000 J. Clin. Invest. pmid:10995790
Fauconnier ML et al. Potato tubers exhibit both homolytic and heterolytic hydroperoxide fatty acid-cleaving activities. 2000 Biochem. Soc. Trans. pmid:11171231
Bürger F et al. Positional- and stereo-selectivity of fatty acid oxygenation catalysed by mouse (12S)-lipoxygenase isoenzymes. 2000 Biochem. J. pmid:10816426
Inouye M et al. Formation of 9-hydroxy linoleic acid as a product of phospholipid peroxidation in diabetic erythrocyte membranes. 1999 Biochim. Biophys. Acta pmid:10320803
Sarraf P et al. Loss-of-function mutations in PPAR gamma associated with human colon cancer. 1999 Mol. Cell pmid:10394368
Bürger F et al. Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes. 1999 Mol. Carcinog. pmid:10078938
Chen NG et al. PPARgamma agonists enhance human vascular endothelial adhesiveness by increasing ICAM-1 expression. 1999 Biochem. Biophys. Res. Commun. pmid:10512746
Jang MK et al. Regulation of ferritin light chain gene expression by oxidized low-density lipoproteins in human monocytic THP-1 cells. 1999 Biochem. Biophys. Res. Commun. pmid:10558912
Truitt A et al. Antiplatelet effects of conjugated linoleic acid isomers. 1999 Biochim. Biophys. Acta pmid:10320806
Jira W et al. Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients. 1998 Chem. Phys. Lipids pmid:9488997
Nagy L et al. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. 1998 Cell pmid:9568715

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