alpha-artemisic acid

Alpha-artemisic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1126 references associated with alpha-artemisic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for alpha-artemisic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-artemisic acid

MeSH term MeSH ID Detail
Adenomatous Polyps D018256 4 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Thrombosis D013927 49 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Familial Mediterranean Fever D010505 12 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hypertension D006973 115 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Arteriosclerosis D001161 86 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 | Total 13

NCBI Entrez Crosslinks

All references with alpha-artemisic acid

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Authors Title Published Journal PubMed Link
Xi S et al. Suppression of proto-oncogene (AP-1) in a model of skin epidermal hyperproliferation is reversed by topical application of 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatrienoic acid. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765974
Ziboh VA et al. Significance of lipoxygenase-derived monohydroxy fatty acids in cutaneous biology. 2000 Prostaglandins Other Lipid Mediat. pmid:11104337
Shureiqi I et al. 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. 2000 J. Natl. Cancer Inst. pmid:10904086
Dandona P et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. 2001 J. Clin. Endocrinol. Metab. pmid:11232024
Aljada A et al. Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action? 2001 J. Clin. Endocrinol. Metab. pmid:11443197
Kelavkar UP et al. Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis. 2001 Carcinogenesis pmid:11698337
Aljada A et al. Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects. 2001 J. Clin. Endocrinol. Metab. pmid:11443177
Ek-Von Mentzer BA et al. Binding of 13-HODE and 15-HETE to phospholipid bilayers, albumin, and intracellular fatty acid binding proteins. implications for transmembrane and intracellular transport and for protection from lipid peroxidation. 2001 J. Biol. Chem. pmid:11278949
Azuma Y et al. 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-10 and IL-12 production by macrophages. 2001 Biochem. Biophys. Res. Commun. pmid:11327705
Hsi LC et al. 15-lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor gamma via the MAPK signaling pathway. 2001 J. Biol. Chem. pmid:11447213
Kim YS et al. The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7. 2001 J. Biol. Chem. pmid:11448950
Shureiqi I et al. Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. 2001 Cancer Res. pmid:11406566
Jude AR et al. 13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases. 2001 Drug Metab. Dispos. pmid:11302930
Fischer B et al. Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma. 2002 J. Immunol. pmid:11884452
Schild RL et al. The activity of PPAR gamma in primary human trophoblasts is enhanced by oxidized lipids. 2002 J. Clin. Endocrinol. Metab. pmid:11889173
Askari B et al. Oleate and linoleate enhance the growth-promoting effects of insulin-like growth factor-I through a phospholipase D-dependent pathway in arterial smooth muscle cells. 2002 J. Biol. Chem. pmid:12138107
Jostarndt K et al. Dissociation of apoptosis induction and CD36 upregulation by enzymatically modified low-density lipoprotein in monocytic cells. 2002 Biochem. Biophys. Res. Commun. pmid:11798172
Hsi LC et al. Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma. 2002 J. Biol. Chem. pmid:12189136
Müller K et al. Modulation of epidermal tumor development caused by targeted overexpression of epidermis-type 12S-lipoxygenase. 2002 Cancer Res. pmid:12183416
Khan-Merchant N et al. Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. 2002 J. Nutr. pmid:12421837
Weichert H et al. Metabolic profiling of oxylipins in germinating cucumber seedlings--lipoxygenase-dependent degradation of triacylglycerols and biosynthesis of volatile aldehydes. 2002 Planta pmid:12172844
Müller C et al. Perturbation of lipid metabolism by linoleic acid hydroperoxide in CaCo-2 cells. 2002 Mar-Apr Biol. Chem. pmid:12033453
Nixon JB et al. Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711249
Pasqualini ME et al. Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538085
Akiba S et al. Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification. 2003 J. Lipid Res. pmid:12777475
Hatley ME et al. Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice. 2003 J. Biol. Chem. pmid:12734208
Wu J et al. 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. 2003 Carcinogenesis pmid:12584173
Shureiqi I et al. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12909723
Kandouz M et al. Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells. 2003 Prostaglandins Other Lipid Mediat. pmid:14518561
Blask DE et al. Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression. 2003 Breast Cancer Res. Treat. pmid:12846415
Cho H et al. Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. 2003 Anal. Biochem. pmid:12782030
Chechetkin IR et al. The novel pathway for ketodiene oxylipin biosynthesis in Jerusalem artichoke (Helianthus tuberosus) tubers. 2004 Biochim. Biophys. Acta pmid:15522817
Coutant F et al. Sensing environmental lipids by dendritic cell modulates its function. 2004 J. Immunol. pmid:14688309
Dauchy RT et al. Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid. 2004 Cancer Lett. pmid:15145516
Blask DE et al. Melatonin uptake and growth prevention in rat hepatoma 7288CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxyoctadecadienoic acid and the potential role of phytomelatonin. 2004 Carcinogenesis pmid:14754876
Tanabe M et al. Incorporation of arachidonic and linoleic acid hydroperoxides into cultured human umbilical vein endothelial cells. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120710
Nixon JB et al. 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643174
Schneider C et al. Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. 2004 Chem. Res. Toxicol. pmid:15257619
Jostarndt K et al. Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way. 2004 Biochem. Pharmacol. pmid:15104237
Hsi LC et al. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells. 2004 Cancer Res. pmid:15574791
Akiba S et al. Translocation of phospholipase A2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester formation. 2004 Biochim. Biophys. Acta pmid:15522824
Hübke H et al. Characterization and quantification of free and esterified 9- and 13-hydroxyoctadecadienoic acids (HODE) in barley, germinating barley, and finished malt. 2005 J. Agric. Food Chem. pmid:15740040
Terao J et al. Glutathione peroxidase mimics as novel antioxidants from vegetables. 2005 Biofactors pmid:15817993
Gerhardt B et al. Lipoxygenase-mediated metabolism of storage lipids in germinating sunflower cotyledons and beta-oxidation of (9Z,11E,13S)-13-hydroxy-octadeca-9,11-dienoic acid by the cotyledonary glyoxysomes. 2005 Planta pmid:15526214
Sauer LA et al. Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. 2005 J. Nutr. pmid:16140887
Shureiqi I et al. The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis. 2005 Cancer Res. pmid:16357157
Manini P et al. Free radical oxidation of coriolic acid (13-(S)-hydroxy-9Z,11E-octadecadienoic acid). 2005 Chem. Phys. Lipids pmid:15784234
Heslin MJ et al. Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer. 2005 Ann. Surg. pmid:15912043
Kim JH et al. Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein. 2005 Biochim. Biophys. Acta pmid:16185917
Cho H et al. Conjugated linoleic acid, cis-9,trans-11, is a substrate for pulmonary 15-lipoxygenase-1 in rat. 2005 J. Agric. Food Chem. pmid:16131140