alpha-artemisic acid

Alpha-artemisic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1126 references associated with alpha-artemisic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for alpha-artemisic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-artemisic acid

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Per page 10 20 | Total 13

NCBI Entrez Crosslinks

All references with alpha-artemisic acid

Download all related citations
Per page 10 20 50 100 | Total 261
Authors Title Published Journal PubMed Link
Vane JR and Botting RM Endothelium--thromboresistance. 1991 Wien. Klin. Wochenschr. pmid:1926866
Buchanan MR et al. 13-Hydroxyoctadecadienoic acid (13-HODE) metabolism and endothelial cell adhesion molecule expression: effect on platelet vessel wall adhesion. 1991 Wien. Klin. Wochenschr. pmid:1718092
Buchanan MR et al. Prevention and treatment of thrombosis: novel strategies arising from our understanding the healthy endothelium. 1993 Wien. Klin. Wochenschr. pmid:8333198
Tavakoli-Yaraki M et al. Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1. 2013 Tumour Biol. pmid:23055198
Hill EM et al. Differentiation dependency of eicosanoid enzyme expression in human tracheobronchial cells. 1998 Toxicol. Lett. pmid:9820673
Bertomeu MC et al. Selective effects of dietary fats on vascular 13-HODE synthesis and platelet/vessel wall interactions. 1990 Thromb. Res. pmid:2237838
Tloti MA et al. Effect of 13-hydroxyoctadeca-9,11-dienoic acid (13-HODE) on thrombin induced platelet adherence to endothelial cells in vitro. 1991 Thromb. Res. pmid:1866713
Weber E et al. Relationship between vessel wall 13-HODE synthesis and vessel wall thrombogenicity following injury: influence of salicylate and dipyridamole treatment. 1990 Thromb. Res. pmid:2315893
Simon TC et al. The induced lipoxygenase in atherosclerotic aorta converts linoleic acid to the platelet chemorepellant factor 13-HODE. 1989 Thromb. Res. pmid:2506664
de Graaf JC et al. Platelet adhesion to subendothelial structures under flow conditions: no effect of the lipoxygenase product 13-HODE. 1989 Thromb. Haemost. pmid:2814928
Yuan H et al. 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. 2010 Thorax pmid:20388757
Mabalirajan U et al. 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma. 2013 Sci Rep pmid:23528921
Ivanov I et al. Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes? 2012 Proteins pmid:22189720
Ziboh VA et al. Significance of lipoxygenase-derived monohydroxy fatty acids in cutaneous biology. 2000 Prostaglandins Other Lipid Mediat. pmid:11104337
Kandouz M et al. Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells. 2003 Prostaglandins Other Lipid Mediat. pmid:14518561
Zuo X and Shureiqi I Eicosanoid profiling in colon cancer: emergence of a pattern. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:22960430
Idborg H et al. Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice. 2013 Prostaglandins Other Lipid Mediat. pmid:23916744
Nixon JB et al. Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711249
Pasqualini ME et al. Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538085
Xi S et al. Suppression of proto-oncogene (AP-1) in a model of skin epidermal hyperproliferation is reversed by topical application of 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatrienoic acid. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765974
Hampel JK et al. Differential modulation of cell cycle, apoptosis and PPARgamma2 gene expression by PPARgamma agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16647253
Buchanan MR et al. Regulation of endothelial cell and platelet receptor-ligand binding by the 12- and 15-lipoxygenase monohydroxides, 12-, 15-HETE and 13-HODE. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690711
Tanabe M et al. Incorporation of arachidonic and linoleic acid hydroperoxides into cultured human umbilical vein endothelial cells. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120710
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Wittwer J and Hersberger M The two faces of the 15-lipoxygenase in atherosclerosis. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17869078
Nixon JB et al. 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643174
Daret D et al. Synthesis of hydroxy fatty acids from linoleic acid by human blood platelets. 1989 Prostaglandins pmid:2505334
Baer AN and Green FA Cyclooxygenase activity of cultured human mesothelial cells. 1993 Prostaglandins pmid:8378541
Spindler SA et al. Occurrence of 13(S)-hydroxyoctadecadienoic acid in biological samples. 1997 Prostaglandins pmid:9533182
Engels F et al. Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. 1996 Prostaglandins pmid:8880897
Engels F et al. Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. 1991 Prostaglandins pmid:1662406
Bull AW et al. Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. 1991 Prostaglandins pmid:2020745
Schade UF et al. The role of lipoxygenases in the activation of macrophages by lipopolysaccharide. 1988 Prog. Clin. Biol. Res. pmid:2839853
Botting R and Vane JR The receipt and dispatch of chemical messengers by endothelial cells. 1989 Prog. Clin. Biol. Res. pmid:2508095
Ney P et al. Hydroxy fatty acid and PGI2 formation in aortic tissue of normo- and hypercholesterolemic rabbits. 1989 Prog. Clin. Biol. Res. pmid:2508111
Aisen PS et al. Circulating hydroxy fatty acids in familial Mediterranean fever. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:3919389
Liu B et al. 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7568126
Shureiqi I et al. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12909723
Gouveia-Figueira S et al. Serum levels of oxylipins in achilles tendinopathy: an exploratory study. 2015 PLoS ONE pmid:25875933
Leghmar K et al. Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures. 2015 PLoS ONE pmid:26171612
Sisignano M et al. Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. 2013 PLoS ONE pmid:24349046
Gerhardt B et al. Lipoxygenase-mediated metabolism of storage lipids in germinating sunflower cotyledons and beta-oxidation of (9Z,11E,13S)-13-hydroxy-octadeca-9,11-dienoic acid by the cotyledonary glyoxysomes. 2005 Planta pmid:15526214
Weichert H et al. Metabolic profiling of oxylipins in germinating cucumber seedlings--lipoxygenase-dependent degradation of triacylglycerols and biosynthesis of volatile aldehydes. 2002 Planta pmid:12172844
Melzig M and Scherke B Effect of metabolites from linoleic acid on migratory behaviour of endothelial cells. 1991 Pharmazie pmid:1886923
Chang J et al. 12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models. 2015 Oncotarget pmid:25576922
Zuo X et al. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. 2006 Oncogene pmid:16288226
Smith LC et al. Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats. 2006 Nutr Cancer pmid:17474866
Glasgow WC et al. Regulation of 13(S)-hydroxyoctadecadienoic acid biosynthesis in Syrian hamster embryo fibroblasts by the epidermal growth factor receptor tyrosine kinase. 1996 Mol. Pharmacol. pmid:8649342
Kim JS et al. Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. 2005 Mol. Cancer Res. pmid:16179498
Ruparel S et al. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 2012 Mol Pain pmid:23006841
Buchanan MR and Bastida E Endothelium and underlying membrane reactivity with platelets, leukocytes and tumor cells: regulation by the lipoxygenase-derived fatty acid metabolites, 13-HODE and HETES. 1988 Med. Hypotheses pmid:3147361
Zha K et al. LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation. 2015 Lipids Health Dis pmid:26302822
Kämmerer I et al. 13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages. 2011 Lipids Health Dis pmid:22129452
Bull AW et al. Regulation of the induction of ornithine decarboxylase in short-term rat colon organ culture by dexamethasone and 13-hydroxyoctadecadienoic acid (13-HODE). 1993 Life Sci. pmid:8326823
Dauchy RT et al. Light contamination during the dark phase in "photoperiodically controlled" animal rooms: effect on tumor growth and metabolism in rats. 1997 Lab. Anim. Sci. pmid:9355094
Stachowska E et al. Apolipoprotein E4 allele is associated with substantial changes in the plasma lipids and hyaluronic acid content in patients with nonalcoholic fatty liver disease. 2013 J. Physiol. Pharmacol. pmid:24388885
Sauer LA et al. Dietary factors and growth and metabolism in experimental tumors. 2007 J. Nutr. Biochem. pmid:17418560
Cho Y and Ziboh VA Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. 1995 J. Nutr. pmid:7472653
Fischer SM et al. Arachidonate has protumor-promoting action that is inhibited by linoleate in mouse skin carcinogenesis. 1996 J. Nutr. pmid:8642440
Khan-Merchant N et al. Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. 2002 J. Nutr. pmid:12421837
Sauer LA et al. Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. 2005 J. Nutr. pmid:16140887
Li D et al. Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. 2015 J. Nutr. pmid:25833778
Shureiqi I et al. 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. 2000 J. Natl. Cancer Inst. pmid:10904086
Cho Y and Ziboh VA Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol. 1994 J. Lipid Res. pmid:8169529
Thomas CE et al. Multiple lipid oxidation products in low density lipoproteins induce interleukin-1 beta release from human blood mononuclear cells. 1994 J. Lipid Res. pmid:8014577
Meilhac O et al. Lipid peroxides induce expression of catalase in cultured vascular cells. 2000 J. Lipid Res. pmid:10946007
Nikkari T et al. Monitoring of lipoprotein oxidation by gas chromatographic analysis of hydroxy fatty acids. 1995 J. Lipid Res. pmid:7706944
Hui R et al. Epidermal growth factor-stimulated production of esterified 13(S)-hydroxyoctadecadienoic acid is associated with tumor suppressor phenotype in Syrian hamster embryo fibroblasts. 1997 J. Lipid Res. pmid:9034199
Fang X et al. 13-(S)-hydroxyoctadecadienoic acid (13-HODE) incorporation and conversion to novel products by endothelial cells. 1999 J. Lipid Res. pmid:10191294
Akiba S et al. Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification. 2003 J. Lipid Res. pmid:12777475
Murthy S et al. 13-hydroxy octadecadienoic acid (13-HODE) inhibits triacylglycerol-rich lipoprotein secretion by CaCo-2 cells. 1998 J. Lipid Res. pmid:9643357
Kang LT and Vanderhoek JY Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin. 1998 J. Lipid Res. pmid:9684751
Folcik VA and Cathcart MK Predominance of esterified hydroperoxy-linoleic acid in human monocyte-oxidized LDL. 1994 J. Lipid Res. pmid:7806971
Baer AN et al. Stereospecificity of the products of the fatty acid oxygenases derived from psoriatic scales. 1991 J. Lipid Res. pmid:1906083
Daret D et al. Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production. 1993 J. Lipid Res. pmid:8228632
van de Velde MJ et al. 13-HODE inhibits the intracellular calcium increase of activated human polymorphonuclear cells. 1994 J. Leukoc. Biol. pmid:8071595
Rolin J and Maghazachi AA Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis. 2014 J. Leukoc. Biol. pmid:24493826
Duell EA et al. Determination of 5,12, and 15-lipoxygenase products in keratomed biopsies of normal and psoriatic skin. 1988 J. Invest. Dermatol. pmid:2844912
Godessart N et al. Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1beta. 1996 J. Invest. Dermatol. pmid:8875957
Miller CC and Ziboh VA Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). 1990 J. Invest. Dermatol. pmid:2106562
Ogawa E et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. 2011 J. Invest. Dermatol. pmid:21068754
Mani I et al. Evidence of nuclear PKC/MAP-kinase cascade in guinea pig model of epidermal hyperproliferation. 1999 J. Invest. Dermatol. pmid:9886262
Matzner Y et al. Generation of lipid neutrophil chemoattractant by irradiated bovine aortic endothelial cells. 1988 J. Immunol. pmid:3128604
Black LL et al. Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice. 2015 J. Immunol. pmid:26466956
Fischer B et al. Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma. 2002 J. Immunol. pmid:11884452
Coutant F et al. Sensing environmental lipids by dendritic cell modulates its function. 2004 J. Immunol. pmid:14688309
Nakamura M et al. Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells. 1995 J. Histochem. Cytochem. pmid:7868854
Yoshinaga M et al. The 15-lipoxygenase-1 expression may enhance the sensitivity to non-steroidal anti-inflammatory drug-induced apoptosis in colorectal cancers from patients who are treated with the compounds. 2007 J. Gastroenterol. Hepatol. pmid:17559385
Kühn H et al. Involvement of 15-lipoxygenase in early stages of atherogenesis. 1994 J. Exp. Med. pmid:8195716
Ikawa H et al. Arachidonate 12-lipoxygenase in porcine anterior pituitary cells: its localization and possible function in gonadotrophs. 1996 J. Endocrinol. pmid:8568469
Han KH et al. Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. 2000 J. Clin. Invest. pmid:10995790
Folcik VA et al. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques. 1995 J. Clin. Invest. pmid:7615823
Kühn H et al. In vivo action of 15-lipoxygenase in early stages of human atherogenesis. 1997 J. Clin. Invest. pmid:9062346
Dandona P et al. The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. 2001 J. Clin. Endocrinol. Metab. pmid:11232024
Aljada A et al. Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action? 2001 J. Clin. Endocrinol. Metab. pmid:11443197
Schild RL et al. The activity of PPAR gamma in primary human trophoblasts is enhanced by oxidized lipids. 2002 J. Clin. Endocrinol. Metab. pmid:11889173
Aljada A et al. Troglitazone reduces the expression of PPARgamma while stimulating that of PPARalpha in mononuclear cells in obese subjects. 2001 J. Clin. Endocrinol. Metab. pmid:11443177
Cimen I et al. 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma. 2011 J. Cell. Biochem. pmid:21544861
Buchanan MR et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. 1985 J. Biol. Chem. pmid:3934168