alpha-artemisic acid

Alpha-artemisic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1126 references associated with alpha-artemisic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for alpha-artemisic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-artemisic acid

MeSH term MeSH ID Detail
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Per page 10 20 | Total 13

NCBI Entrez Crosslinks

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Authors Title Published Journal PubMed Link
Cho Y and Ziboh VA Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. 1995 J. Nutr. pmid:7472653
Khan-Merchant N et al. Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. 2002 J. Nutr. pmid:12421837
Sauer LA et al. Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway. 2005 J. Nutr. pmid:16140887
Sauer LA et al. Dietary factors and growth and metabolism in experimental tumors. 2007 J. Nutr. Biochem. pmid:17418560
Stachowska E et al. Apolipoprotein E4 allele is associated with substantial changes in the plasma lipids and hyaluronic acid content in patients with nonalcoholic fatty liver disease. 2013 J. Physiol. Pharmacol. pmid:24388885
Dauchy RT et al. Light contamination during the dark phase in "photoperiodically controlled" animal rooms: effect on tumor growth and metabolism in rats. 1997 Lab. Anim. Sci. pmid:9355094
Bull AW et al. Regulation of the induction of ornithine decarboxylase in short-term rat colon organ culture by dexamethasone and 13-hydroxyoctadecadienoic acid (13-HODE). 1993 Life Sci. pmid:8326823
Zha K et al. LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation. 2015 Lipids Health Dis pmid:26302822
Kämmerer I et al. 13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages. 2011 Lipids Health Dis pmid:22129452
Buchanan MR and Bastida E Endothelium and underlying membrane reactivity with platelets, leukocytes and tumor cells: regulation by the lipoxygenase-derived fatty acid metabolites, 13-HODE and HETES. 1988 Med. Hypotheses pmid:3147361
Ruparel S et al. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 2012 Mol Pain pmid:23006841
Kim JS et al. Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. 2005 Mol. Cancer Res. pmid:16179498
Glasgow WC et al. Regulation of 13(S)-hydroxyoctadecadienoic acid biosynthesis in Syrian hamster embryo fibroblasts by the epidermal growth factor receptor tyrosine kinase. 1996 Mol. Pharmacol. pmid:8649342
Smith LC et al. Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats. 2006 Nutr Cancer pmid:17474866
Zuo X et al. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. 2006 Oncogene pmid:16288226
Chang J et al. 12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models. 2015 Oncotarget pmid:25576922
Melzig M and Scherke B Effect of metabolites from linoleic acid on migratory behaviour of endothelial cells. 1991 Pharmazie pmid:1886923
Gerhardt B et al. Lipoxygenase-mediated metabolism of storage lipids in germinating sunflower cotyledons and beta-oxidation of (9Z,11E,13S)-13-hydroxy-octadeca-9,11-dienoic acid by the cotyledonary glyoxysomes. 2005 Planta pmid:15526214
Weichert H et al. Metabolic profiling of oxylipins in germinating cucumber seedlings--lipoxygenase-dependent degradation of triacylglycerols and biosynthesis of volatile aldehydes. 2002 Planta pmid:12172844
Gouveia-Figueira S et al. Serum levels of oxylipins in achilles tendinopathy: an exploratory study. 2015 PLoS ONE pmid:25875933
Leghmar K et al. Cytomegalovirus Infection Triggers the Secretion of the PPARγ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures. 2015 PLoS ONE pmid:26171612
Sisignano M et al. Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. 2013 PLoS ONE pmid:24349046
Aisen PS et al. Circulating hydroxy fatty acids in familial Mediterranean fever. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:3919389
Liu B et al. 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7568126
Shureiqi I et al. The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12909723
Schade UF et al. The role of lipoxygenases in the activation of macrophages by lipopolysaccharide. 1988 Prog. Clin. Biol. Res. pmid:2839853
Botting R and Vane JR The receipt and dispatch of chemical messengers by endothelial cells. 1989 Prog. Clin. Biol. Res. pmid:2508095
Ney P et al. Hydroxy fatty acid and PGI2 formation in aortic tissue of normo- and hypercholesterolemic rabbits. 1989 Prog. Clin. Biol. Res. pmid:2508111
Daret D et al. Synthesis of hydroxy fatty acids from linoleic acid by human blood platelets. 1989 Prostaglandins pmid:2505334
Baer AN and Green FA Cyclooxygenase activity of cultured human mesothelial cells. 1993 Prostaglandins pmid:8378541
Spindler SA et al. Occurrence of 13(S)-hydroxyoctadecadienoic acid in biological samples. 1997 Prostaglandins pmid:9533182
Engels F et al. Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. 1996 Prostaglandins pmid:8880897
Engels F et al. Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. 1991 Prostaglandins pmid:1662406
Bull AW et al. Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. 1991 Prostaglandins pmid:2020745
Nixon JB et al. Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711249
Pasqualini ME et al. Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538085
Xi S et al. Suppression of proto-oncogene (AP-1) in a model of skin epidermal hyperproliferation is reversed by topical application of 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatrienoic acid. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765974
Hampel JK et al. Differential modulation of cell cycle, apoptosis and PPARgamma2 gene expression by PPARgamma agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16647253
Buchanan MR et al. Regulation of endothelial cell and platelet receptor-ligand binding by the 12- and 15-lipoxygenase monohydroxides, 12-, 15-HETE and 13-HODE. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690711
Tanabe M et al. Incorporation of arachidonic and linoleic acid hydroperoxides into cultured human umbilical vein endothelial cells. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120710
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Wittwer J and Hersberger M The two faces of the 15-lipoxygenase in atherosclerosis. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17869078
Nixon JB et al. 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643174
Ziboh VA et al. Significance of lipoxygenase-derived monohydroxy fatty acids in cutaneous biology. 2000 Prostaglandins Other Lipid Mediat. pmid:11104337
Kandouz M et al. Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells. 2003 Prostaglandins Other Lipid Mediat. pmid:14518561
Zuo X and Shureiqi I Eicosanoid profiling in colon cancer: emergence of a pattern. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:22960430
Idborg H et al. Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice. 2013 Prostaglandins Other Lipid Mediat. pmid:23916744
Ivanov I et al. Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes? 2012 Proteins pmid:22189720
Mabalirajan U et al. 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma. 2013 Sci Rep pmid:23528921
Yuan H et al. 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. 2010 Thorax pmid:20388757
de Graaf JC et al. Platelet adhesion to subendothelial structures under flow conditions: no effect of the lipoxygenase product 13-HODE. 1989 Thromb. Haemost. pmid:2814928
Bertomeu MC et al. Selective effects of dietary fats on vascular 13-HODE synthesis and platelet/vessel wall interactions. 1990 Thromb. Res. pmid:2237838
Tloti MA et al. Effect of 13-hydroxyoctadeca-9,11-dienoic acid (13-HODE) on thrombin induced platelet adherence to endothelial cells in vitro. 1991 Thromb. Res. pmid:1866713
Weber E et al. Relationship between vessel wall 13-HODE synthesis and vessel wall thrombogenicity following injury: influence of salicylate and dipyridamole treatment. 1990 Thromb. Res. pmid:2315893
Simon TC et al. The induced lipoxygenase in atherosclerotic aorta converts linoleic acid to the platelet chemorepellant factor 13-HODE. 1989 Thromb. Res. pmid:2506664
Hill EM et al. Differentiation dependency of eicosanoid enzyme expression in human tracheobronchial cells. 1998 Toxicol. Lett. pmid:9820673
Tavakoli-Yaraki M et al. Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1. 2013 Tumour Biol. pmid:23055198
Vane JR and Botting RM Endothelium--thromboresistance. 1991 Wien. Klin. Wochenschr. pmid:1926866
Buchanan MR et al. 13-Hydroxyoctadecadienoic acid (13-HODE) metabolism and endothelial cell adhesion molecule expression: effect on platelet vessel wall adhesion. 1991 Wien. Klin. Wochenschr. pmid:1718092
Buchanan MR et al. Prevention and treatment of thrombosis: novel strategies arising from our understanding the healthy endothelium. 1993 Wien. Klin. Wochenschr. pmid:8333198