| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
Total
2
Epicatechin-3-gallate
Epicatechin-3-gallate is a lipid of Polyketides (PK) class. Epicatechin-3-gallate is associated with abnormalities such as Epilepsy and Megalencephaly. The involved functions are known as Docking, Drug Interactions, inhibitors, Oxidation and Inflammation Process. Epicatechin-3-gallate often locates in Solitary microtubule component of centriole or axonemal complex, Palmar surface, Glial and peritoneal. The associated genes with Epicatechin-3-gallate are Homologous Gene and TSC1 gene.
Cross Reference
Introduction
To understand associated biological information of Epicatechin-3-gallate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epicatechin-3-gallate?
Epicatechin-3-gallate is suspected in Epilepsy, Megalencephaly and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epicatechin-3-gallate
PubChem Associated disorders and diseases
What pathways are associated with Epicatechin-3-gallate
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epicatechin-3-gallate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Epicatechin-3-gallate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epicatechin-3-gallate?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epicatechin-3-gallate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epicatechin-3-gallate?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epicatechin-3-gallate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lin CL et al. | Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. | 2007 | J. Lipid Res. | pmid:17720960 |
| Katiyar SK et al. | Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols. | 1995 | J. Invest. Dermatol. | pmid:7665919 |
| Ryan P and Hynes MJ | The kinetics and mechanisms of the complex formation and antioxidant behaviour of the polyphenols EGCg and ECG with iron(III). | 2007 | J. Inorg. Biochem. | pmid:17257683 |
| Ghosh KS et al. | Studies on the interaction of copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate with calf thymus DNA. | 2008 | J. Inorg. Biochem. | pmid:18541305 |
| Liu TT and Yang TS | Effects of water-soluble natural antioxidants on photosensitized oxidation of conjugated linoleic acid in an oil-in-water emulsion system. | 2008 | J. Food Sci. | pmid:18460119 |
| Yuda N et al. | Polyphenols extracted from black tea (Camellia sinensis) residue by hot-compressed water and their inhibitory effect on pancreatic lipase in vitro. | 2012 | J. Food Sci. | pmid:23106349 |
| Chiu CT et al. | Hibiscus sabdariffa leaf polyphenolic extract induces human melanoma cell death, apoptosis, and autophagy. | 2015 | J. Food Sci. | pmid:25694272 |
| Tagashira T et al. | Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate. | 2012 | J. Food Sci. | pmid:22938538 |
| Chung JH et al. | Green tea formulations with vitamin C and xylitol on enhanced intestinal transport of green tea catechins. | 2013 | J. Food Sci. | pmid:23551173 |
| El-Hawary SA et al. | A profile of bioactive compounds of Rumex vesicarius L. | 2011 | J. Food Sci. | pmid:22417584 |
| Cui L et al. | Extraction of Epigallocatechin Gallate and Epicatechin Gallate from Tea Leaves Using β-Cyclodextrin. | 2017 | J. Food Sci. | pmid:28071811 |
| Zhang QH et al. | Simultaneous determination of catechin, epicatechin and epicatechin gallate in rat plasma by LC-ESI-MS/MS for pharmacokinetic studies after oral administration of Cynomorium songaricum extract. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22153330 |
| Peng J et al. | Separation and purification of four phenolic compounds from persimmon by high-speed counter-current chromatography. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29136554 |
| Narumi K et al. | Simultaneous detection of green tea catechins and gallic acid in human serum after ingestion of green tea tablets using ion-pair high-performance liquid chromatography with electrochemical detection. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24342507 |
| Fu T et al. | Simultaneous determination of the major active components of tea polyphenols in rat plasma by a simple and specific HPLC assay. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18922746 |
| Landis-Piwowar KR et al. | Methylation suppresses the proteasome-inhibitory function of green tea polyphenols. | 2007 | J. Cell. Physiol. | pmid:17477351 |
| Lo HM et al. | Tea polyphenols inhibit rat vascular smooth muscle cell adhesion and migration on collagen and laminin via interference with cell-ECM interaction. | 2007 | J. Biomed. Sci. | pmid:17436062 |
| Yoshiki Y et al. | Mechanism of catechin chemiluminescence in the presence of active oxygen. | 1996 May-Jun | J. Biolumin. Chemilumin. | pmid:8844343 |
| Byun MR et al. | (-)-Epicatechin gallate (ECG) stimulates osteoblast differentiation via Runt-related transcription factor 2 (RUNX2) and transcriptional coactivator with PDZ-binding motif (TAZ)-mediated transcriptional activation. | 2014 | J. Biol. Chem. | pmid:24515112 |
| Bernal P et al. | Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. | 2010 | J. Biol. Chem. | pmid:20516078 |
| Li C et al. | Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site. | 2011 | J. Biol. Chem. | pmid:21813650 |
| Taniguchi S et al. | Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. | 2005 | J. Biol. Chem. | pmid:15611092 |
| Bernal P et al. | Disruption of D-alanyl esterification of Staphylococcus aureus cell wall teichoic acid by the {beta}-lactam resistance modifier (-)-epicatechin gallate. | 2009 | J. Antimicrob. Chemother. | pmid:19307172 |
| Saito ST et al. | Characterization of the constituents and antioxidant activity of Brazilian green tea (Camellia sinensis var. assamica IAC-259 cultivar) extracts. | 2007 | J. Agric. Food Chem. | pmid:17937477 |
| de Freitas V and Mateus N | Structural features of procyanidin interactions with salivary proteins. | 2001 | J. Agric. Food Chem. | pmid:11262053 |
| Yao L et al. | Seasonal variations of phenolic compounds in Australia-grown tea (Camellia sinensis). | 2005 | J. Agric. Food Chem. | pmid:16076137 |
| Yin J et al. | Reduction of ferrylmyoglobin by theanine and green tea catechins. Importance of specific Acid catalysis. | 2013 | J. Agric. Food Chem. | pmid:23461366 |
| Sánchez-Tena S et al. | Epicatechin gallate impairs colon cancer cell metabolic productivity. | 2013 | J. Agric. Food Chem. | pmid:23594085 |
| Nakagawa T et al. | Protective activity of green tea against free radical- and glucose-mediated protein damage. | 2002 | J. Agric. Food Chem. | pmid:11929306 |
| Hossain SJ et al. | Effects of tea components on the response of GABA(A) receptors expressed in Xenopus Oocytes. | 2002 | J. Agric. Food Chem. | pmid:12083865 |
| Wollmann N and Hofmann T | Compositional and sensory characterization of red wine polymers. | 2013 | J. Agric. Food Chem. | pmid:23387831 |
| Anderson RA and Polansky MM | Tea enhances insulin activity. | 2002 | J. Agric. Food Chem. | pmid:12428980 |
| Sakanaka S | A novel convenient process to obtain a raw decaffeinated tea polyphenol fraction using a lignocellulose column. | 2003 | J. Agric. Food Chem. | pmid:12720405 |
| John KM et al. | Electrofocusing of methanolic extracts for identification of individual flavonol biomolecules in Camellia species. | 2006 | J. Agric. Food Chem. | pmid:16608196 |
| Kohri T et al. | Identification of metabolites of (-)-epicatechin gallate and their metabolic fate in the rat. | 2003 | J. Agric. Food Chem. | pmid:12926915 |
| Hossain SJ et al. | Polyphenol-induced inhibition of the response of na(+)/glucose cotransporter expressed in Xenopus oocytes. | 2002 | J. Agric. Food Chem. | pmid:12188632 |
| Jo JY et al. | Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. | 2006 | J. Agric. Food Chem. | pmid:16536579 |
| Maeda-Yamamoto M et al. | Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells. | 1999 | J. Agric. Food Chem. | pmid:10794635 |
| Konishi Y et al. | Tea polyphenols inhibit the transport of dietary phenolic acids mediated by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers. | 2003 | J. Agric. Food Chem. | pmid:14640574 |
| Ikeda I et al. | Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate. | 2003 | J. Agric. Food Chem. | pmid:14640575 |
| Fulcrand H et al. | Study of wine tannin oligomers by on-line liquid chromatography electrospray ionization mass spectrometry. | 1999 | J. Agric. Food Chem. | pmid:10552410 |
| Chen Z et al. | Degradation of green tea catechins in tea drinks. | 2001 | J. Agric. Food Chem. | pmid:11170614 |
| Ferreira PG et al. | Stimulation of acidic reduction of nitrite to nitric oxide by soybean phenolics: possible relevance to gastrointestinal host defense. | 2011 | J. Agric. Food Chem. | pmid:21510708 |
| Appeldoorn MM et al. | Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. | 2009 | J. Agric. Food Chem. | pmid:19722703 |
| Saito M et al. | Green tea polyphenols inhibit metalloproteinase activities in the skin, muscle, and blood of rainbow trout. | 2002 | J. Agric. Food Chem. | pmid:12428978 |
| Kobayashi Y et al. | Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. | 2000 | J. Agric. Food Chem. | pmid:11087528 |
| Mata-Bilbao Mde L et al. | A new LC/MS/MS rapid and sensitive method for the determination of green tea catechins and their metabolites in biological samples. | 2007 | J. Agric. Food Chem. | pmid:17902624 |
| Uekusa Y et al. | Dynamic behavior of tea catechins interacting with lipid membranes as determined by NMR spectroscopy. | 2007 | J. Agric. Food Chem. | pmid:17966973 |
| Danila AM et al. | Determination of rutin, catechin, epicatechin, and epicatechin gallate in buckwheat Fagopyrum esculentum Moench by micro-high-performance liquid chromatography with electrochemical detection. | 2007 | J. Agric. Food Chem. | pmid:17253718 |
| Noda Y and Peterson DG | Structure-reactivity relationships of flavan-3-ols on product generation in aqueous glucose/glycine model systems. | 2007 | J. Agric. Food Chem. | pmid:17394338 |
| Kyle JA et al. | Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea. | 2007 | J. Agric. Food Chem. | pmid:17489604 |
| Wang R et al. | Kinetic study of the thermal stability of tea catechins in aqueous systems using a microwave reactor. | 2006 | J. Agric. Food Chem. | pmid:16881696 |
| Shen D et al. | Determination of the predominant catechins in Acacia catechu by liquid chromatography/electrospray ionization-mass spectrometry. | 2006 | J. Agric. Food Chem. | pmid:16637676 |
| Neilson AP et al. | Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion. | 2007 | J. Agric. Food Chem. | pmid:17924707 |
| Nitta Y et al. | Food components inhibiting recombinant human histidine decarboxylase activity. | 2007 | J. Agric. Food Chem. | pmid:17227057 |
| Mitani S et al. | Stopped-flow kinetic study of the aroxyl radical-scavenging action of catechins and vitamin C in ethanol and micellar solutions. | 2008 | J. Agric. Food Chem. | pmid:18500808 |
| Jumtee K et al. | Fast GC-FID based metabolic fingerprinting of Japanese green tea leaf for its quality ranking prediction. | 2009 | J Sep Sci | pmid:19569110 |
| Müller P and Downard KM | Catechin inhibition of influenza neuraminidase and its molecular basis with mass spectrometry. | 2015 | J Pharm Biomed Anal | pmid:25910046 |
| Mukai D et al. | Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans. | 2008 | J Nat Med | pmid:18404315 |
| Abib RT et al. | Genoprotective effects of the green tea-derived polyphenol/epicatechin gallate in C6 astroglial cells. | 2010 | J Med Food | pmid:20828315 |
| Jackson JK et al. | The inhibition of collagenase induced degradation of collagen by the galloyl-containing polyphenols tannic acid, epigallocatechin gallate and epicatechin gallate. | 2010 | J Mater Sci Mater Med | pmid:20162329 |
| Sarni-Manchado P and Cheynier V | Study of non-covalent complexation between catechin derivatives and peptides by electrospray ionization mass spectrometry. | 2002 | J Mass Spectrom | pmid:12112743 |
| Dhanani T et al. | Extraction optimization of gallic acid, (+)-catechin, procyanidin-B2, (-)-epicatechin, (-)-epigallocatechin gallate, and (-)-epicatechin gallate: their simultaneous identification and quantification in Saraca asoca. | 2017 | J Food Drug Anal | pmid:28911654 |
| Godsey J and Grundmann O | Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer. | 2016 | J Diet Suppl | pmid:26863913 |
| Abourashed EA et al. | Content Variation of Catechin Markers, Total Phenolics and Caffeine in Green Tea Dietary Supplements. | 2016 | J Diet Suppl | pmid:25299974 |
| Siddique YH et al. | Effect of epicatechin gallate dietary supplementation on transgenic Drosophila model of Parkinson's disease. | 2014 | J Diet Suppl | pmid:24670116 |
| Kumar NS and Rajapaksha M | Separation of catechin constituents from five tea cultivars using high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:16078712 |
| Du Q et al. | Scaling up of high-speed countercurrent chromatographic apparatus with three columns connected in series for rapid preparation of (-)-epicatechin. | 2013 | J Chromatogr A | pmid:23219478 |
| Haginaka J et al. | Uniformly-sized, molecularly imprinted polymers for (-)-epigallocatechin gallate, -epicatechin gallate and -gallocatechin gallate by multi-step swelling and polymerization method. | 2007 | J Chromatogr A | pmid:17070533 |
| Si W et al. | Bioassay-guided purification and identification of antimicrobial components in Chinese green tea extract. | 2006 | J Chromatogr A | pmid:16797571 |
| Peek J et al. | Identification of Novel Polyphenolic Inhibitors of Shikimate Dehydrogenase (AroE). | 2014 | J Biomol Screen | pmid:24632659 |
| Roman MC | Determination of catechins and caffeine in camillia sinensis raw materials, extracts, and dietary supplements by HPLC-uv: single-laboratory validation. | 2013 Sep-Oct | J AOAC Int | pmid:24282928 |
| Koch W et al. | Catechin Composition and Antioxidant Activity of Black Teas in Relation to Brewing Time. | 2017 | J AOAC Int | pmid:28707612 |
| Park JS et al. | EGCG inhibits recepteur d'origine nantais expression by suppressing Egr-1 in gastric cancer cells. | 2013 | Int. J. Oncol. | pmid:23337910 |
| Nakamuta M et al. | Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells. | 2005 | Int. J. Mol. Med. | pmid:16142404 |
| Daniel KG et al. | Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome beta5 subunit. | 2006 | Int. J. Mol. Med. | pmid:16964415 |
| Stapleton PD et al. | Epicatechin gallate, a component of green tea, reduces halotolerance in Staphylococcus aureus. | 2006 | Int. J. Food Microbiol. | pmid:16839636 |
| Kim JH et al. | Inhibitory activity of (-)-epicatechin-3,5-O-digallate on α-glucosidase and in silico analysis. | 2018 | Int. J. Biol. Macromol. | pmid:28958819 |
| Lei S et al. | Effective synthesis of theaflavin-3,3'-digallate with epigallocatechin-3-O-gallate and epicatechin gallate as substrates by using immobilized pear polyphenol oxidase. | 2017 | Int. J. Biol. Macromol. | pmid:27780760 |
| Ghosh S et al. | (-)-Epicatechin gallate prevents alkali-salt mediated fibrillogenesis of hen egg white lysozyme. | 2013 | Int. J. Biol. Macromol. | pmid:23219698 |
| Krych J and Gebicka L | Catalase is inhibited by flavonoids. | 2013 | Int. J. Biol. Macromol. | pmid:23567286 |
| Stapleton PD et al. | Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallates. | 2004 | Int. J. Antimicrob. Agents | pmid:15120724 |
| Cushnie TP and Lamb AJ | Recent advances in understanding the antibacterial properties of flavonoids. | 2011 | Int. J. Antimicrob. Agents | pmid:21514796 |
| Shen JM et al. | Chitosan-based luminescent/magnetic hybrid nanogels for insulin delivery, cell imaging, and antidiabetic research of dietary supplements. | 2012 | Int J Pharm | pmid:22342466 |
| Zhang L et al. | Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. | 2004 | Int J Pharm | pmid:15541906 |
| Jun X et al. | Separation of major catechins from green tea by ultrahigh pressure extraction. | 2010 | Int J Pharm | pmid:19874878 |
| Farhan M et al. | Mobilization of Nuclear Copper by Green Tea Polyphenol Epicatechin-3-Gallate and Subsequent Prooxidant Breakage of Cellular DNA: Implications for Cancer Chemotherapy. | 2016 | Int J Mol Sci | pmid:28035959 |
| Rosado H et al. | Impact of the β-Lactam Resistance Modifier (-)-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus. | 2015 | Int J Mol Sci | pmid:26213914 |
| Qin R et al. | The combination of catechin and epicatechin callate from Fructus Crataegi potentiates beta-lactam antibiotics against methicillin-resistant staphylococcus aureus (MRSA) in vitro and in vivo. | 2013 | Int J Mol Sci | pmid:23325048 |
| Zheng R et al. | A comparative reverse docking strategy to identify potential antineoplastic targets of tea functional components and binding mode. | 2011 | Int J Mol Sci | pmid:21954353 |
| Nakanishi T et al. | Catechins inhibit vascular endothelial growth factor production and cyclooxygenase-2 expression in human dental pulp cells. | 2015 | Int Endod J | pmid:24847951 |
| Fujisawa S et al. | A quantitative approach to the free radical interaction between alpha-tocopherol or ascorbate and flavonoids. | 2006 Jul-Aug | In Vivo | pmid:16900773 |
| Zhang Y et al. | [Assessment of inner filter effect corrections in fluorimetry of the interaction between polyphenols and proteins]. | 2014 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:24783545 |
| Soe WM et al. | In vitro drug interactions of gallates with antibiotics in Staphylococcus Aureus. | 2010 | Front Biosci (Elite Ed) | pmid:20036910 |
| Crespy V et al. | Glucuronidation of the green tea catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by rat hepatic and intestinal microsomes. | 2004 | Free Radic. Res. | pmid:15621722 |
| Caturla N et al. | The relationship between the antioxidant and the antibacterial properties of galloylated catechins and the structure of phospholipid model membranes. | 2003 | Free Radic. Biol. Med. | pmid:12633742 |
| Chiou YS et al. | Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia. | 2016 | Free Radic. Biol. Med. | pmid:26878775 |
| Zhong Z et al. | Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats. | 2004 | Free Radic. Biol. Med. | pmid:15110390 |
| Bors W and Michel C | Antioxidant capacity of flavanols and gallate esters: pulse radiolysis studies. | 1999 | Free Radic. Biol. Med. | pmid:10641736 |
| Galati G et al. | Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. | 2006 | Free Radic. Biol. Med. | pmid:16458187 |