SCHEMBL2576454

SCHEMBL2576454 is a lipid of Polyketides (PK) class.

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Current reference collection contains 301 references associated with SCHEMBL2576454 in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
pmid:
Lall N and Meyer JJ Inhibition of drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis by diospyrin, isolated from Euclea natalensis. 2001 J Ethnopharmacol pmid:11694367
Chakrabarty S et al. Induction of apoptosis in human cancer cell lines by diospyrin, a plant-derived bisnaphthoquinonoid, and its synthetic derivatives. 2002 Cancer Lett. pmid:12406552
Lall N et al. Antimycobacterial activity of diospyrin derivatives and a structural analogue of diospyrin against Mycobacterium tuberculosis in vitro. 2003 J. Antimicrob. Chemother. pmid:12562718
Westphal S and Kalthoff H Apoptosis: targets in pancreatic cancer. 2003 Mol. Cancer pmid:12605713
Sanyal U et al. Liquid chromatographic separation of derivatives of diospyrin, a bioactive bisnaphthoquinonoid plant-product, and analogous naphthyl compounds. 2003 J Chromatogr A pmid:14584707
Harrison WT and Musgrave OC Diospyrin. 2004 Acta Crystallogr C pmid:15178863
Ganapaty S et al. Antitermitic quinones from Diospyros sylvatica. 2004 Phytochemistry pmid:15184011
Hazra B et al. Separation methods of quinonoid constituents of plants used in Oriental traditional medicines. 2004 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15556503
Hayeshi R et al. The interaction of selected natural products with human recombinant glutathione transferases. 2004 Phytother Res pmid:15597303
Tazi J et al. Selective inhibition of topoisomerase I and various steps of spliceosome assembly by diospyrin derivatives. 2005 Mol. Pharmacol. pmid:15625279
Hazra B et al. Enhancement of the tumour inhibitory activity, in vivo, of diospyrin, a plant-derived quinonoid, through liposomal encapsulation. 2005 Toxicol. Lett. pmid:15836998
Gupta S et al. New pharmaceutical microemulsion system for encapsulation and delivery of diospyrin, a plant-derived bioactive quinonoid compound. 2006 May-Jun Drug Deliv pmid:16556571
Ganapaty S et al. Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis. 2006 Phytochemistry pmid:16890968
Hazra B et al. Cytotoxicity of diospyrin and its derivatives in relation to the generation of reactive oxygen species in tumour cells in vitro and in vivo. 2007 Chemotherapy pmid:17347562
Das Sarma M et al. Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid. 2007 Bioorg. Med. Chem. pmid:17400463
Kumar B et al. Radiosensitization by diospyrin diethylether in MCF-7 breast carcinoma cell line. 2007 Mol. Cell. Biochem. pmid:17534696
Chhabra S et al. A computational docking study for prediction of binding mode of diospyrin and derivatives: Inhibitors of human and leishmanial DNA topoisomerase-I. 2007 Bioorg. Med. Chem. Lett. pmid:17562360
Sarma MD et al. Novel glycoconjugates of diospyrin, a quinonoid plant product: synthesis and evaluation of cytotoxicity against human malignant melanoma (A375) and laryngeal carcinoma (Hep2). 2007 Org. Biomol. Chem. pmid:17878970
Retraction notice to "A computational docking study for prediction of binding mode of diospyrin and derivatives: Inhibitors of human and leishmanial DNA topoisomerase-I" [Bioorg. Med. Chem. Lett. 17 (2007) 4604-4612]. 2007 Bioorg. Med. Chem. Lett. pmid:17987674
Das Sarma M et al. Synthesis of novel aminoquinonoid analogues of diospyrin and evaluation of their inhibitory activity against murine and human cancer cells. 2008 Eur J Med Chem pmid:18281125
Kantamreddi VS and Wright CW Investigation of Indian diospyros species for antiplasmodial properties. 2008 Evid Based Complement Alternat Med pmid:18604258
Kumar B et al. Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells. 2009 Mol. Cell. Biochem. pmid:18836818
de Oliveira Costa C et al. Development of a voltammetric sensor for diospyrin determination in nanomolar concentrations. 2006 Talanta pmid:18970475
van Alphen RJ et al. The spliceosome as target for anticancer treatment. 2009 Br. J. Cancer pmid:19034274
Mukherjee P et al. Apoptosis-like death in Leishmania donovani promastigotes induced by diospyrin and its ethanolamine derivative. 2009 Int. J. Antimicrob. Agents pmid:19783125
Sagar S et al. Anti-cancer activities of diospyrin, its derivatives and analogues. 2010 Eur J Med Chem pmid:20615584
Juge F et al. The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown. 2010 PLoS Genet. pmid:20862310
Smirlis D et al. Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death. 2010 Parasit Vectors pmid:21083891
Mukherjee A et al. 6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis. 2010 J. Exp. Clin. Cancer Res. pmid:21194464
Fonseca-Silva F et al. Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis. 2011 PLoS ONE pmid:21346801
Subramaniya BR et al. Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2. 2011 PLoS ONE pmid:21559086
Pinho BR et al. Is nitric oxide decrease observed with naphthoquinones in LPS stimulated RAW 264.7 macrophages a beneficial property? 2011 PLoS ONE pmid:21887376
Duncan R et al. Identification and characterization of genes involved in leishmania pathogenesis: the potential for drug target selection. 2011 Mol Biol Int pmid:22091403
Wang X et al. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. 2011 Chem. Biodivers. pmid:22162171
Landa P et al. Redox and non-redox mechanism of in vitro cyclooxygenase inhibition by natural quinones. 2012 Planta Med. pmid:22174077
Holzmann K et al. Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer. 2012 J Nucleic Acids pmid:22203889
Kumar B et al. Diospyrin derivative, an anticancer quinonoid, regulates apoptosis at endoplasmic reticulum as well as mitochondria by modulating cytosolic calcium in human breast carcinoma cells. 2012 Biochem. Biophys. Res. Commun. pmid:22209849
Baikar S and Malpathak N Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. 2010 Pharmacogn Rev pmid:22228937
Nematollahi A et al. Reviews on 1,4-naphthoquinones from Diospyros L. 2012 J Asian Nat Prod Res pmid:22263598
Hazra B et al. The prospective role of plant products in radiotherapy of cancer: a current overview. 2011 Front Pharmacol pmid:22291649