MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus | D003920 | 90 associated lipids |
Diabetic Nephropathies | D003928 | 39 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Prostatic Neoplasms | D011471 | 126 associated lipids |
Procyanidin B2 is a lipid of Polyketides (PK) class. The involved functions are known as conjugation, Methylation, Excretory function, enzyme activity and sulfatase activity. Procyanidin b2 often locates in Blood, Epidermis and Upper Gastrointestinal Tract. The associated genes with Procyanidin B2 are NR5A2 gene, HRAS wt Allele, CFB gene, PTGS2 gene and MAPK8 gene.
To understand associated biological information of Procyanidin B2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Procyanidin B2
MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus | D003920 | 90 associated lipids |
Diabetic Nephropathies | D003928 | 39 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Prostatic Neoplasms | D011471 | 126 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Xiao Y et al. | Procyanidin B2 protects against d-galactose-induced mimetic aging in mice: Metabolites and microbiome analysis. | 2018 | Food Chem. Toxicol. | pmid:29751077 |
Fayeulle N et al. | Characterization of new flavan-3-ol derivatives in fermented cocoa beans. | 2018 | Food Chem | pmid:29680045 |
Vallejo-Ochoa J et al. | Early plant growth and biochemical responses induced by Azospirillum brasilense Sp245 lipopolysaccharides in wheat (Triticum aestivum L.) seedlings are attenuated by procyanidin B2. | 2018 | Protoplasma | pmid:29110138 |
Deng M et al. | Effect of Storage Conditions on Phenolic Profiles and Antioxidant Activity of Litchi Pericarp. | 2018 | Molecules | pmid:30200581 |
Shi Q et al. | Comparative Analysis of Pigments, Phenolics, and Antioxidant Activity of Chinese Jujube ( Mill.) during Fruit Development. | 2018 | Molecules | pmid:30071615 |
Saenger T et al. | Short-term biomarkers of apple consumption. | 2017 | Mol Nutr Food Res | pmid:27794196 |
Wang W et al. | Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28844677 |
Matić P et al. | Validation of Spectrophotometric Methods for the Determination of Total Polyphenol and Total Flavonoid Content. | 2017 | J AOAC Int | pmid:28730980 |
Yin M et al. | Grape seed procyanidin B2 ameliorates hepatic lipid metabolism disorders in db/db mice. | 2017 | Mol Med Rep | pmid:28677803 |
Chen Y et al. | Anti-myocardial Ischemia Effect and Components of Litchi Pericarp Extracts. | 2017 | Phytother Res | pmid:28744920 |
Kim AN et al. | The effect of grinding at various vacuum levels on the color, phenolics, and antioxidant properties of apple. | 2017 | Food Chem | pmid:27596414 |
Novakovic A et al. | Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery. | 2017 | Eur. J. Pharmacol. | pmid:28414054 |
Tanaka S et al. | Procyanidin B2 gallates inhibit IFN-γ and IL-17 production in T cells by suppressing T-bet and RORγt expression. | 2017 | Int. Immunopharmacol. | pmid:28088699 |
Sereia AL et al. | Capillary Electrophoresis as Tool for Diastereomeric Separation in a Trichilia catigua Fraction. | 2017 | Phytochem Anal | pmid:27910216 |
Escott C et al. | Characterization of polymeric pigments and pyranoanthocyanins formed in microfermentations of non-Saccharomyces yeasts. | 2016 | J. Appl. Microbiol. | pmid:27511798 |
Cuadrado-Silva CT et al. | Targeted Metabolomic Analysis of Polyphenols with Antioxidant Activity in Sour Guava (Psidium friedrichsthalianum Nied.) Fruit. | 2016 | Molecules | pmid:28025550 |
Zhang JQ et al. | Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2. | 2016 | Oxid Med Cell Longev | pmid:27057282 |
Wang A et al. | Procyanidins Mitigate Osteoarthritis Pathogenesis by, at Least in Part, Suppressing Vascular Endothelial Growth Factor Signaling. | 2016 | Int J Mol Sci | pmid:27941690 |
Cherubin P et al. | Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds. | 2016 | PLoS ONE | pmid:27829022 |
Zhou Y et al. | Restoration of Mimecan Expression by Grape Seed Procyanidin B2 Through Regulation of Nuclear Factor-kappaB in Mice With Diabetic Nephropathy. | 2016 | Iran J Kidney Dis | pmid:27721232 |
Cai X et al. | Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro. | 2016 | Food Funct | pmid:26650960 |
Li W et al. | Supplementation of procyanidins B2 attenuates photooxidation-induced apoptosis in ARPE-19 cells. | 2016 | Int J Food Sci Nutr | pmid:27251367 |
Tessarin P et al. | Influence of canopy-applied chitosan on the composition of organic cv. Sangiovese and Cabernet Sauvignon berries and wines. | 2016 | Food Chem | pmid:27211677 |
Lima Mdos S et al. | Phenolic compounds, organic acids and antioxidant activity of grape juices produced in industrial scale by different processes of maceration. | 2015 | Food Chem | pmid:26041208 |
Liszt KI et al. | Identification of Catechin, Syringic Acid, and Procyanidin B2 in Wine as Stimulants of Gastric Acid Secretion. | 2015 | J. Agric. Food Chem. | pmid:26244870 |
Wu S et al. | Procyanidin B2 attenuates neurological deficits and blood-brain barrier disruption in a rat model of cerebral ischemia. | 2015 | Mol Nutr Food Res | pmid:26228251 |
Yin W et al. | Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas. | 2015 | Food Funct | pmid:26207855 |
Schmuch J et al. | Extract from Rumex acetosa L. for prophylaxis of periodontitis: inhibition of bacterial in vitro adhesion and of gingipains of Porphyromonas gingivalis by epicatechin-3-O-(4β→8)-epicatechin-3-O-gallate (procyanidin-B2-Di-gallate). | 2015 | PLoS ONE | pmid:25803708 |
Zuriarrain A et al. | Polyphenolic profile in cider and antioxidant power. | 2015 | J. Sci. Food Agric. | pmid:25475490 |
Yang BY et al. | Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice. | 2015 | Molecules | pmid:26151119 |
Kopustinskiene DM et al. | Direct effects of (-)-epicatechin and procyanidin B2 on the respiration of rat heart mitochondria. | 2015 | Biomed Res Int | pmid:25811024 |
Bao L et al. | Grape seed procyanidin B2 ameliorates mitochondrial dysfunction and inhibits apoptosis via the AMP-activated protein kinase-silent mating type information regulation 2 homologue 1-PPARγ co-activator-1α axis in rat mesangial cells under high-dose glucosamine. | 2015 | Br. J. Nutr. | pmid:25404010 |
Jiang X et al. | Analysis of accumulation patterns and preliminary study on the condensation mechanism of proanthocyanidins in the tea plant [Camellia sinensis]. | 2015 | Sci Rep | pmid:25735226 |
Wen L et al. | Phenolic contents and cellular antioxidant activity of Chinese hawthorn "Crataegus pinnatifida". | 2015 | Food Chem | pmid:25976791 |
Martinez-Micaelo N et al. | Procyanidin B2 inhibits inflammasome-mediated IL-1β production in lipopolysaccharide-stimulated macrophages. | 2015 | Mol Nutr Food Res | pmid:25379992 |
Yin W et al. | Critical role of prohibitin in endothelial cell apoptosis caused by glycated low-density lipoproteins and protective effects of grape seed procyanidin B2. | 2015 | J. Cardiovasc. Pharmacol. | pmid:25343566 |
Li D et al. | Procyanidin B2 inhibits high glucose‑induced epithelial‑mesenchymal transition in HK‑2 human renal proximal tubular epithelial cells. | 2015 | Mol Med Rep | pmid:26498003 |
Shilpi A et al. | Mechanisms of DNA methyltransferase-inhibitor interactions: Procyanidin B2 shows new promise for therapeutic intervention of cancer. | 2015 | Chem. Biol. Interact. | pmid:25839702 |
Luan SS et al. | Quantitative proteomics study of protective effects of grape seed procyanidin B2 on diabetic cardiomyopathy in db/db mice. | 2014 | Biosci. Biotechnol. Biochem. | pmid:25209507 |
Muthenna P et al. | Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. | 2014 | Chem. Biol. Interact. | pmid:25199697 |
De Taeye C et al. | Degradation of (-)-epicatechin and procyanidin B2 in aqueous and lipidic model systems. first evidence of "chemical" flavan-3-ol oligomers in processed cocoa. | 2014 | J. Agric. Food Chem. | pmid:25167469 |
Espley RV et al. | Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice. | 2014 | J. Nutr. | pmid:24353343 |
Gaivelyte K et al. | Variation of quantitative composition of phenolic compounds in rowan (Sorbus aucuparia L.) leaves during the growth season. | 2014 | Nat. Prod. Res. | pmid:24697599 |
Baselga-Escudero L et al. | Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. | 2014 | Nucleic Acids Res. | pmid:24165878 |
Ou K et al. | Microbial catabolism of procyanidins by human gut microbiota. | 2014 | Mol Nutr Food Res | pmid:25045165 |
Ekuadzi E et al. | Chemical constituents from Gouania longipetala and Glyphaea brevis. | 2014 | Nat. Prod. Res. | pmid:24910899 |
Yang H et al. | Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells. | 2014 | Biochem. Pharmacol. | pmid:25450671 |
Jeong JH et al. | An investigation into the ameliorating effect of black soybean extract on learning and memory impairment with assessment of neuroprotective effects. | 2014 | BMC Complement Altern Med | pmid:25496367 |
Bai X et al. | Antioxidant activity and HPLC analysis of polyphenol-enriched extracts from industrial apple pomace. | 2013 | J. Sci. Food Agric. | pmid:23460126 |
Zhang Z et al. | Proteomic analysis of kidney and protective effects of grape seed procyanidin B2 in db/db mice indicate MFG-E8 as a key molecule in the development of diabetic nephropathy. | 2013 | Biochim. Biophys. Acta | pmid:23474305 |
Li XL et al. | PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. | 2013 | PLoS ONE | pmid:23922881 |
Fukami H et al. | Isolation of a reduced form of cyanidin 3-O-β-D-glucoside from immature black soybean (Glycine max (L.) Merr.) and its reducing properties. | 2013 | J Oleo Sci | pmid:23985492 |
Suda M et al. | Syntheses of procyanidin B2 and B3 gallate derivatives using equimolar condensation mediated by Yb(OTf)3 and their antitumor activities. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23867167 |
Muthenna P et al. | Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. | 2013 | IUBMB Life | pmid:24136906 |
Tanaka K et al. | Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis. | 2013 | Nat Prod Commun | pmid:23472464 |
Sung NY et al. | Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23872113 |
Zhang J et al. | Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats. | 2013 | J Ethnopharmacol | pmid:23685195 |
Alvarez AL et al. | Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds. | 2012 | Phytother Res | pmid:22318977 |
Martinez-Micaelo N et al. | Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. | 2012 | Biochem. J. | pmid:21954853 |
RodrÃguez-Ramiro I et al. | Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress. | 2012 | Eur J Nutr | pmid:22042007 |
Feliciano RP et al. | Comparison of isolated cranberry (Vaccinium macrocarpon Ait.) proanthocyanidins to catechin and procyanidins A2 and B2 for use as standards in the 4-(dimethylamino)cinnamaldehyde assay. | 2012 | J. Agric. Food Chem. | pmid:22533362 |
Zumdick S et al. | In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells. | 2012 | Fitoterapia | pmid:22776719 |
Ottaviani JI et al. | Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. | 2012 | Am. J. Clin. Nutr. | pmid:22378733 |
Yu F et al. | Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage. | 2012 | PLoS ONE | pmid:23285083 |
Shrestha SP et al. | Glucuronidation and methylation of procyanidin dimers b2 and 3,3″-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver. | 2012 | Pharm. Res. | pmid:22068277 |
Crupi P et al. | HPLC-DAD-ESI-MS analysis of flavonoid compounds in 5 seedless table grapes grown in Apulian Region. | 2012 | J. Food Sci. | pmid:22309436 |
RodrÃguez-Ramiro I et al. | Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. | 2011 | J. Nutr. Biochem. | pmid:21334869 |
Li BY et al. | Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol. | 2011 | Apoptosis | pmid:21505870 |
Li BY et al. | Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation. | 2011 | Cell Biol. Int. | pmid:21244366 |
Kahle K et al. | Intestinal transit and systemic metabolism of apple polyphenols. | 2011 | Eur J Nutr | pmid:21184087 |
Poupard P et al. | Characterization of procyanidin B2 oxidation products in an apple juice model solution and confirmation of their presence in apple juice by high-performance liquid chromatography coupled to electrospray ion trap mass spectrometry. | 2011 | J Mass Spectrom | pmid:22124992 |
Cai Q et al. | Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21897042 |
Ramos S et al. | Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells. | 2011 | Toxicol In Vitro | pmid:21945981 |
RodrÃguez-Ramiro I et al. | Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells. | 2011 | Eur J Nutr | pmid:21046126 |
Gescher K et al. | Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1. | 2011 | Antiviral Res. | pmid:21070811 |
Stoupi S et al. | In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. | 2010 | Drug Metab. Dispos. | pmid:19910517 |
Stoupi S et al. | Procyanidin B2 catabolism by human fecal microflora: partial characterization of 'dimeric' intermediates. | 2010 | Arch. Biochem. Biophys. | pmid:20188693 |
Stoupi S et al. | A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota. | 2010 | Mol Nutr Food Res | pmid:19943260 |
Chou SC et al. | Influence of gallate esterification on the activity of procyanidin B2 in androgen-dependent human prostate carcinoma LNCaP cells. | 2010 | Pharm. Res. | pmid:20162340 |
Cho ES et al. | Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. | 2009 | Free Radic. Biol. Med. | pmid:19248828 |
Appeldoorn MM et al. | Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats. | 2009 | J. Nutr. | pmid:19494022 |
Takeshita M et al. | Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA. | 2009 | J. Biol. Chem. | pmid:19531480 |
Qa'dan F et al. | Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo. | 2009 | J Ethnopharmacol | pmid:19397981 |
Jung M et al. | Influence of apple polyphenols on inflammatory gene expression. | 2009 | Mol Nutr Food Res | pmid:19764067 |
Lee KW et al. | Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. | 2008 | Cardiovasc. Res. | pmid:18310679 |
Xiao JS et al. | Rapid preparation of procyanidins B2 and C1 from Granny Smith apples by using low pressure column chromatography and identification of their oligomeric procyanidins. | 2008 | J. Agric. Food Chem. | pmid:18298060 |
Cho ES et al. | Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK. | 2008 | Mutat. Res. | pmid:18272186 |
Mackenzie GG et al. | Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. | 2008 | Biochem. Pharmacol. | pmid:18275936 |
Kang NJ et al. | Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. | 2008 | J. Biol. Chem. | pmid:18519570 |
Zhou DN et al. | [Phenols from the rhizomes of Arachniodes exilis]. | 2008 | Zhong Yao Cai | pmid:18619264 |
Hosoi S et al. | Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography-mass spectrometry. | 2008 | J Nat Med | pmid:18404300 |
Huang XZ et al. | [Studies on chemical constituents from roots of Craibiodendron henryi]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17583200 |
Contreras-DomÃnguez M et al. | Degradation of procyanidins by Aspergillus fumigatus: identification of a novel aromatic ring cleavage product. | 2006 | Biochimie | pmid:16905239 |
Chen DM et al. | Inhibitory effects of procyanidin B(2) dimer on lipid-laden macrophage formation. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16954822 |
Kamimura A et al. | Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced apoptosis in hair epithelial cells: an insight into their mechanisms. | 2006 | Skin Pharmacol Physiol | pmid:16778458 |
Zhang WY et al. | Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16681998 |
Jo JY et al. | Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. | 2006 | J. Agric. Food Chem. | pmid:16536579 |
Sakano K et al. | Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage. | 2005 | Free Radic. Biol. Med. | pmid:16198231 |
Saito A et al. | Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases. | 2005 | Bioorg. Med. Chem. | pmid:15781387 |
Nomoto H et al. | Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. | 2004 | Nutr Cancer | pmid:15456639 |