| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
Total
4
Procyanidin B2
Procyanidin B2 is a lipid of Polyketides (PK) class. The involved functions are known as conjugation, Methylation, Excretory function, enzyme activity and sulfatase activity. Procyanidin b2 often locates in Blood, Epidermis and Upper Gastrointestinal Tract. The associated genes with Procyanidin B2 are NR5A2 gene, HRAS wt Allele, CFB gene, PTGS2 gene and MAPK8 gene.
Cross Reference
Introduction
To understand associated biological information of Procyanidin B2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Procyanidin B2?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Procyanidin B2
PubChem Associated disorders and diseases
What pathways are associated with Procyanidin B2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Procyanidin B2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Procyanidin B2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Procyanidin B2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Procyanidin B2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Procyanidin B2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Procyanidin B2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Wang JN et al. | Antioxidant activity of polyphenols from seeds of Vitis amurensis in vitro. | 2000 | Acta Pharmacol. Sin. | pmid:11360672 |
| Ottaviani JI et al. | Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. | 2012 | Am. J. Clin. Nutr. | pmid:22378733 |
| Gescher K et al. | Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1. | 2011 | Antiviral Res. | pmid:21070811 |
| Li BY et al. | Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol. | 2011 | Apoptosis | pmid:21505870 |
| Stoupi S et al. | Procyanidin B2 catabolism by human fecal microflora: partial characterization of 'dimeric' intermediates. | 2010 | Arch. Biochem. Biophys. | pmid:20188693 |
| Wittig J et al. | Quantification of procyanidins in oral herbal medicinal products containing extracts of Crataegus species. | 2002 | Arzneimittelforschung | pmid:11878204 |
| Zhang WY et al. | Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16681998 |
| Wang W et al. | Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28844677 |
| Sung NY et al. | Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23872113 |
| Martinez-Micaelo N et al. | Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. | 2012 | Biochem. J. | pmid:21954853 |
| Mackenzie GG et al. | Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. | 2008 | Biochem. Pharmacol. | pmid:18275936 |
| Yang H et al. | Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells. | 2014 | Biochem. Pharmacol. | pmid:25450671 |
| Zhang Z et al. | Proteomic analysis of kidney and protective effects of grape seed procyanidin B2 in db/db mice indicate MFG-E8 as a key molecule in the development of diabetic nephropathy. | 2013 | Biochim. Biophys. Acta | pmid:23474305 |
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| Luan SS et al. | Quantitative proteomics study of protective effects of grape seed procyanidin B2 on diabetic cardiomyopathy in db/db mice. | 2014 | Biosci. Biotechnol. Biochem. | pmid:25209507 |
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| Jeong JH et al. | An investigation into the ameliorating effect of black soybean extract on learning and memory impairment with assessment of neuroprotective effects. | 2014 | BMC Complement Altern Med | pmid:25496367 |
| Bao L et al. | Grape seed procyanidin B2 ameliorates mitochondrial dysfunction and inhibits apoptosis via the AMP-activated protein kinase-silent mating type information regulation 2 homologue 1-PPARγ co-activator-1α axis in rat mesangial cells under high-dose glucosamine. | 2015 | Br. J. Nutr. | pmid:25404010 |
| Zhao J et al. | Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. | 1999 | Carcinogenesis | pmid:10469619 |
| Lee KW et al. | Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. | 2008 | Cardiovasc. Res. | pmid:18310679 |
| Li BY et al. | Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation. | 2011 | Cell Biol. Int. | pmid:21244366 |
| Muthenna P et al. | Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. | 2014 | Chem. Biol. Interact. | pmid:25199697 |
| Shilpi A et al. | Mechanisms of DNA methyltransferase-inhibitor interactions: Procyanidin B2 shows new promise for therapeutic intervention of cancer. | 2015 | Chem. Biol. Interact. | pmid:25839702 |
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| RodrÃguez-Ramiro I et al. | Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells. | 2011 | Eur J Nutr | pmid:21046126 |
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| Novakovic A et al. | Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery. | 2017 | Eur. J. Pharmacol. | pmid:28414054 |
| Osakabe N et al. | Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. | 2002 | Exp. Biol. Med. (Maywood) | pmid:11788784 |
| Zumdick S et al. | In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells. | 2012 | Fitoterapia | pmid:22776719 |
| Lima Mdos S et al. | Phenolic compounds, organic acids and antioxidant activity of grape juices produced in industrial scale by different processes of maceration. | 2015 | Food Chem | pmid:26041208 |
| Fayeulle N et al. | Characterization of new flavan-3-ol derivatives in fermented cocoa beans. | 2018 | Food Chem | pmid:29680045 |
| Kim AN et al. | The effect of grinding at various vacuum levels on the color, phenolics, and antioxidant properties of apple. | 2017 | Food Chem | pmid:27596414 |
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| Tessarin P et al. | Influence of canopy-applied chitosan on the composition of organic cv. Sangiovese and Cabernet Sauvignon berries and wines. | 2016 | Food Chem | pmid:27211677 |
| Xiao Y et al. | Procyanidin B2 protects against d-galactose-induced mimetic aging in mice: Metabolites and microbiome analysis. | 2018 | Food Chem. Toxicol. | pmid:29751077 |
| Yin W et al. | Anti-inflammatory effects of grape seed procyanidin B2 on a diabetic pancreas. | 2015 | Food Funct | pmid:26207855 |
| Cai X et al. | Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro. | 2016 | Food Funct | pmid:26650960 |
| Baba S et al. | Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats. | 2002 | Free Radic. Biol. Med. | pmid:12086692 |
| Cho ES et al. | Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. | 2009 | Free Radic. Biol. Med. | pmid:19248828 |
| Sakano K et al. | Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage. | 2005 | Free Radic. Biol. Med. | pmid:16198231 |
| Li W et al. | Supplementation of procyanidins B2 attenuates photooxidation-induced apoptosis in ARPE-19 cells. | 2016 | Int J Food Sci Nutr | pmid:27251367 |
| Wang A et al. | Procyanidins Mitigate Osteoarthritis Pathogenesis by, at Least in Part, Suppressing Vascular Endothelial Growth Factor Signaling. | 2016 | Int J Mol Sci | pmid:27941690 |
| Tanaka S et al. | Procyanidin B2 gallates inhibit IFN-γ and IL-17 production in T cells by suppressing T-bet and RORγt expression. | 2017 | Int. Immunopharmacol. | pmid:28088699 |