Procyanidin B2

Procyanidin B2 is a lipid of Polyketides (PK) class. The involved functions are known as conjugation, Methylation, Excretory function, enzyme activity and sulfatase activity. Procyanidin b2 often locates in Blood, Epidermis and Upper Gastrointestinal Tract. The associated genes with Procyanidin B2 are NR5A2 gene, HRAS wt Allele, CFB gene, PTGS2 gene and MAPK8 gene.

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Introduction

To understand associated biological information of Procyanidin B2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Procyanidin B2

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Procyanidin B2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Procyanidin B2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Procyanidin B2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Procyanidin B2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Procyanidin B2

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Authors Title Published Journal PubMed Link
Huang XZ et al. [Studies on chemical constituents from roots of Craibiodendron henryi]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17583200
Zhou DN et al. [Phenols from the rhizomes of Arachniodes exilis]. 2008 Zhong Yao Cai pmid:18619264
Ramos S et al. Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells. 2011 Toxicol In Vitro pmid:21945981
Kamimura A et al. Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced apoptosis in hair epithelial cells: an insight into their mechanisms. 2006 Skin Pharmacol Physiol pmid:16778458
Jiang X et al. Analysis of accumulation patterns and preliminary study on the condensation mechanism of proanthocyanidins in the tea plant [Camellia sinensis]. 2015 Sci Rep pmid:25735226
Vallejo-Ochoa J et al. Early plant growth and biochemical responses induced by Azospirillum brasilense Sp245 lipopolysaccharides in wheat (Triticum aestivum L.) seedlings are attenuated by procyanidin B2. 2018 Protoplasma pmid:29110138
Yu F et al. Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage. 2012 PLoS ONE pmid:23285083
Li XL et al. PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. 2013 PLoS ONE pmid:23922881
Schmuch J et al. Extract from Rumex acetosa L. for prophylaxis of periodontitis: inhibition of bacterial in vitro adhesion and of gingipains of Porphyromonas gingivalis by epicatechin-3-O-(4β→8)-epicatechin-3-O-gallate (procyanidin-B2-Di-gallate). 2015 PLoS ONE pmid:25803708
Cherubin P et al. Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds. 2016 PLoS ONE pmid:27829022
Shahat AA et al. Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica. 2002 Planta Med. pmid:12094299
Butterweck V et al. Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats. 2003 Planta Med. pmid:12677519
Abrahams S et al. Identification and biochemical characterization of mutants in the proanthocyanidin pathway in Arabidopsis. 2002 Plant Physiol. pmid:12376625
Alvarez AL et al. Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds. 2012 Phytother Res pmid:22318977
Chen Y et al. Anti-myocardial Ischemia Effect and Components of Litchi Pericarp Extracts. 2017 Phytother Res pmid:28744920
Hussein G et al. Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease. 1999 Phytother Res pmid:10189947
Sereia AL et al. Capillary Electrophoresis as Tool for Diastereomeric Separation in a Trichilia catigua Fraction. 2017 Phytochem Anal pmid:27910216
Quettier-Deleu C et al. Hawthorn extracts inhibit LDL oxidation. 2003 Pharmazie pmid:12967038
Butterweck V et al. Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment. 2001 Pharmacopsychiatry pmid:11518068
Chou SC et al. Influence of gallate esterification on the activity of procyanidin B2 in androgen-dependent human prostate carcinoma LNCaP cells. 2010 Pharm. Res. pmid:20162340
Shrestha SP et al. Glucuronidation and methylation of procyanidin dimers b2 and 3,3″-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver. 2012 Pharm. Res. pmid:22068277
Zhang JQ et al. Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2. 2016 Oxid Med Cell Longev pmid:27057282
Nomoto H et al. Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. 2004 Nutr Cancer pmid:15456639
Waffo-Téguo P et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. 2001 Nutr Cancer pmid:11962253
Baselga-Escudero L et al. Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. 2014 Nucleic Acids Res. pmid:24165878
Gaivelyte K et al. Variation of quantitative composition of phenolic compounds in rowan (Sorbus aucuparia L.) leaves during the growth season. 2014 Nat. Prod. Res. pmid:24697599
Ekuadzi E et al. Chemical constituents from Gouania longipetala and Glyphaea brevis. 2014 Nat. Prod. Res. pmid:24910899
Tanaka K et al. Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis. 2013 Nat Prod Commun pmid:23472464
Bahorun T et al. Phenolic constituents and antioxidant capacities of Crataegus monogyna (Hawthorn) callus extracts. 2003 Nahrung pmid:12866623
Cho ES et al. Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK. 2008 Mutat. Res. pmid:18272186
Cuadrado-Silva CT et al. Targeted Metabolomic Analysis of Polyphenols with Antioxidant Activity in Sour Guava (Psidium friedrichsthalianum Nied.) Fruit. 2016 Molecules pmid:28025550
Yang BY et al. Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice. 2015 Molecules pmid:26151119
Deng M et al. Effect of Storage Conditions on Phenolic Profiles and Antioxidant Activity of Litchi Pericarp. 2018 Molecules pmid:30200581
Shi Q et al. Comparative Analysis of Pigments, Phenolics, and Antioxidant Activity of Chinese Jujube ( Mill.) during Fruit Development. 2018 Molecules pmid:30071615
Stoupi S et al. A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota. 2010 Mol Nutr Food Res pmid:19943260
Saenger T et al. Short-term biomarkers of apple consumption. 2017 Mol Nutr Food Res pmid:27794196
Ou K et al. Microbial catabolism of procyanidins by human gut microbiota. 2014 Mol Nutr Food Res pmid:25045165
Wu S et al. Procyanidin B2 attenuates neurological deficits and blood-brain barrier disruption in a rat model of cerebral ischemia. 2015 Mol Nutr Food Res pmid:26228251
Martinez-Micaelo N et al. Procyanidin B2 inhibits inflammasome-mediated IL-1β production in lipopolysaccharide-stimulated macrophages. 2015 Mol Nutr Food Res pmid:25379992
Jung M et al. Influence of apple polyphenols on inflammatory gene expression. 2009 Mol Nutr Food Res pmid:19764067
Yin M et al. Grape seed procyanidin B2 ameliorates hepatic lipid metabolism disorders in db/db mice. 2017 Mol Med Rep pmid:28677803
Li D et al. Procyanidin B2 inhibits high glucose‑induced epithelial‑mesenchymal transition in HK‑2 human renal proximal tubular epithelial cells. 2015 Mol Med Rep pmid:26498003
Bai X et al. Antioxidant activity and HPLC analysis of polyphenol-enriched extracts from industrial apple pomace. 2013 J. Sci. Food Agric. pmid:23460126
Zuriarrain A et al. Polyphenolic profile in cider and antioxidant power. 2015 J. Sci. Food Agric. pmid:25475490
Kozikowski AP et al. Studies in polyphenol chemistry and bioactivity. 2. Establishment of interflavan linkage regio- and stereochemistry by oxidative degradation of an O-alkylated derivative of procyanidin B2 to (R)-(-)-2,4-diphenylbutyric acid. 2000 J. Org. Chem. pmid:10993368
Rodríguez-Ramiro I et al. Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. 2011 J. Nutr. Biochem. pmid:21334869
Appeldoorn MM et al. Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats. 2009 J. Nutr. pmid:19494022
Espley RV et al. Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice. 2014 J. Nutr. pmid:24353343
Kakiuchi N et al. Inhibitory effect of tannins on reverse transcriptase from RNA tumor virus. 1985 Jul-Aug J. Nat. Prod. pmid:2413172
Haslam E Natural polyphenols (vegetable tannins) as drugs: possible modes of action. 1996 J. Nat. Prod. pmid:8991956