MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus | D003920 | 90 associated lipids |
Diabetic Nephropathies | D003928 | 39 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Prostatic Neoplasms | D011471 | 126 associated lipids |
Procyanidin B2 is a lipid of Polyketides (PK) class. The involved functions are known as conjugation, Methylation, Excretory function, enzyme activity and sulfatase activity. Procyanidin b2 often locates in Blood, Epidermis and Upper Gastrointestinal Tract. The associated genes with Procyanidin B2 are NR5A2 gene, HRAS wt Allele, CFB gene, PTGS2 gene and MAPK8 gene.
To understand associated biological information of Procyanidin B2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Procyanidin B2
MeSH term | MeSH ID | Detail |
---|---|---|
Diabetes Mellitus | D003920 | 90 associated lipids |
Diabetic Nephropathies | D003928 | 39 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Prostatic Neoplasms | D011471 | 126 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Cai Q et al. | Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21897042 |
Jeong JH et al. | An investigation into the ameliorating effect of black soybean extract on learning and memory impairment with assessment of neuroprotective effects. | 2014 | BMC Complement Altern Med | pmid:25496367 |
Bao L et al. | Grape seed procyanidin B2 ameliorates mitochondrial dysfunction and inhibits apoptosis via the AMP-activated protein kinase-silent mating type information regulation 2 homologue 1-PPARγ co-activator-1α axis in rat mesangial cells under high-dose glucosamine. | 2015 | Br. J. Nutr. | pmid:25404010 |
Zhao J et al. | Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. | 1999 | Carcinogenesis | pmid:10469619 |
Lee KW et al. | Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. | 2008 | Cardiovasc. Res. | pmid:18310679 |
Li BY et al. | Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation. | 2011 | Cell Biol. Int. | pmid:21244366 |
Muthenna P et al. | Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. | 2014 | Chem. Biol. Interact. | pmid:25199697 |
Shilpi A et al. | Mechanisms of DNA methyltransferase-inhibitor interactions: Procyanidin B2 shows new promise for therapeutic intervention of cancer. | 2015 | Chem. Biol. Interact. | pmid:25839702 |
Stoupi S et al. | In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. | 2010 | Drug Metab. Dispos. | pmid:19910517 |
Kahle K et al. | Intestinal transit and systemic metabolism of apple polyphenols. | 2011 | Eur J Nutr | pmid:21184087 |
RodrÃguez-Ramiro I et al. | Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress. | 2012 | Eur J Nutr | pmid:22042007 |
RodrÃguez-Ramiro I et al. | Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells. | 2011 | Eur J Nutr | pmid:21046126 |
Hostanska K et al. | Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. | 2003 | Eur J Pharm Biopharm | pmid:12837490 |
Novakovic A et al. | Endothelium-dependent vasorelaxant effect of procyanidin B2 on human internal mammary artery. | 2017 | Eur. J. Pharmacol. | pmid:28414054 |
Osakabe N et al. | Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. | 2002 | Exp. Biol. Med. (Maywood) | pmid:11788784 |
Zumdick S et al. | In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells. | 2012 | Fitoterapia | pmid:22776719 |
Fayeulle N et al. | Characterization of new flavan-3-ol derivatives in fermented cocoa beans. | 2018 | Food Chem | pmid:29680045 |
Kim AN et al. | The effect of grinding at various vacuum levels on the color, phenolics, and antioxidant properties of apple. | 2017 | Food Chem | pmid:27596414 |
Wen L et al. | Phenolic contents and cellular antioxidant activity of Chinese hawthorn "Crataegus pinnatifida". | 2015 | Food Chem | pmid:25976791 |
Tessarin P et al. | Influence of canopy-applied chitosan on the composition of organic cv. Sangiovese and Cabernet Sauvignon berries and wines. | 2016 | Food Chem | pmid:27211677 |