| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
Total
4
Procyanidin B2
Procyanidin B2 is a lipid of Polyketides (PK) class. The involved functions are known as conjugation, Methylation, Excretory function, enzyme activity and sulfatase activity. Procyanidin b2 often locates in Blood, Epidermis and Upper Gastrointestinal Tract. The associated genes with Procyanidin B2 are NR5A2 gene, HRAS wt Allele, CFB gene, PTGS2 gene and MAPK8 gene.
Cross Reference
Introduction
To understand associated biological information of Procyanidin B2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Procyanidin B2?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Procyanidin B2
PubChem Associated disorders and diseases
What pathways are associated with Procyanidin B2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Procyanidin B2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Procyanidin B2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Procyanidin B2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Procyanidin B2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Procyanidin B2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Procyanidin B2
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|---|---|---|---|---|
| Bai X et al. | Antioxidant activity and HPLC analysis of polyphenol-enriched extracts from industrial apple pomace. | 2013 | J. Sci. Food Agric. | pmid:23460126 |
| Zhang Z et al. | Proteomic analysis of kidney and protective effects of grape seed procyanidin B2 in db/db mice indicate MFG-E8 as a key molecule in the development of diabetic nephropathy. | 2013 | Biochim. Biophys. Acta | pmid:23474305 |
| Suda M et al. | Syntheses of procyanidin B2 and B3 gallate derivatives using equimolar condensation mediated by Yb(OTf)3 and their antitumor activities. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23867167 |
| Muthenna P et al. | Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. | 2013 | IUBMB Life | pmid:24136906 |
| Tanaka K et al. | Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis. | 2013 | Nat Prod Commun | pmid:23472464 |
| Sung NY et al. | Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23872113 |
| Zhang J et al. | Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats. | 2013 | J Ethnopharmacol | pmid:23685195 |
| Alvarez AL et al. | Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds. | 2012 | Phytother Res | pmid:22318977 |
| Martinez-Micaelo N et al. | Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. | 2012 | Biochem. J. | pmid:21954853 |
| RodrÃguez-Ramiro I et al. | Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress. | 2012 | Eur J Nutr | pmid:22042007 |
| Feliciano RP et al. | Comparison of isolated cranberry (Vaccinium macrocarpon Ait.) proanthocyanidins to catechin and procyanidins A2 and B2 for use as standards in the 4-(dimethylamino)cinnamaldehyde assay. | 2012 | J. Agric. Food Chem. | pmid:22533362 |
| Zumdick S et al. | In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells. | 2012 | Fitoterapia | pmid:22776719 |
| Ottaviani JI et al. | Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. | 2012 | Am. J. Clin. Nutr. | pmid:22378733 |
| Yu F et al. | Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage. | 2012 | PLoS ONE | pmid:23285083 |
| Shrestha SP et al. | Glucuronidation and methylation of procyanidin dimers b2 and 3,3″-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver. | 2012 | Pharm. Res. | pmid:22068277 |
| Crupi P et al. | HPLC-DAD-ESI-MS analysis of flavonoid compounds in 5 seedless table grapes grown in Apulian Region. | 2012 | J. Food Sci. | pmid:22309436 |
| RodrÃguez-Ramiro I et al. | Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. | 2011 | J. Nutr. Biochem. | pmid:21334869 |
| Li BY et al. | Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol. | 2011 | Apoptosis | pmid:21505870 |
| Li BY et al. | Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation. | 2011 | Cell Biol. Int. | pmid:21244366 |
| Kahle K et al. | Intestinal transit and systemic metabolism of apple polyphenols. | 2011 | Eur J Nutr | pmid:21184087 |
| Poupard P et al. | Characterization of procyanidin B2 oxidation products in an apple juice model solution and confirmation of their presence in apple juice by high-performance liquid chromatography coupled to electrospray ion trap mass spectrometry. | 2011 | J Mass Spectrom | pmid:22124992 |
| Cai Q et al. | Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21897042 |
| Ramos S et al. | Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells. | 2011 | Toxicol In Vitro | pmid:21945981 |
| RodrÃguez-Ramiro I et al. | Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells. | 2011 | Eur J Nutr | pmid:21046126 |
| Gescher K et al. | Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1. | 2011 | Antiviral Res. | pmid:21070811 |
| Stoupi S et al. | In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. | 2010 | Drug Metab. Dispos. | pmid:19910517 |
| Stoupi S et al. | Procyanidin B2 catabolism by human fecal microflora: partial characterization of 'dimeric' intermediates. | 2010 | Arch. Biochem. Biophys. | pmid:20188693 |
| Stoupi S et al. | A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota. | 2010 | Mol Nutr Food Res | pmid:19943260 |
| Chou SC et al. | Influence of gallate esterification on the activity of procyanidin B2 in androgen-dependent human prostate carcinoma LNCaP cells. | 2010 | Pharm. Res. | pmid:20162340 |
| Cho ES et al. | Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. | 2009 | Free Radic. Biol. Med. | pmid:19248828 |
| Appeldoorn MM et al. | Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats. | 2009 | J. Nutr. | pmid:19494022 |
| Takeshita M et al. | Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA. | 2009 | J. Biol. Chem. | pmid:19531480 |
| Qa'dan F et al. | Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo. | 2009 | J Ethnopharmacol | pmid:19397981 |
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| Lee KW et al. | Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. | 2008 | Cardiovasc. Res. | pmid:18310679 |
| Xiao JS et al. | Rapid preparation of procyanidins B2 and C1 from Granny Smith apples by using low pressure column chromatography and identification of their oligomeric procyanidins. | 2008 | J. Agric. Food Chem. | pmid:18298060 |
| Cho ES et al. | Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK. | 2008 | Mutat. Res. | pmid:18272186 |
| Mackenzie GG et al. | Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. | 2008 | Biochem. Pharmacol. | pmid:18275936 |
| Kang NJ et al. | Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. | 2008 | J. Biol. Chem. | pmid:18519570 |
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| Hosoi S et al. | Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography-mass spectrometry. | 2008 | J Nat Med | pmid:18404300 |
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| Contreras-DomÃnguez M et al. | Degradation of procyanidins by Aspergillus fumigatus: identification of a novel aromatic ring cleavage product. | 2006 | Biochimie | pmid:16905239 |
| Chen DM et al. | Inhibitory effects of procyanidin B(2) dimer on lipid-laden macrophage formation. | 2006 | J. Cardiovasc. Pharmacol. | pmid:16954822 |
| Kamimura A et al. | Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced apoptosis in hair epithelial cells: an insight into their mechanisms. | 2006 | Skin Pharmacol Physiol | pmid:16778458 |
| Zhang WY et al. | Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16681998 |
| Jo JY et al. | Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. | 2006 | J. Agric. Food Chem. | pmid:16536579 |
| Sakano K et al. | Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage. | 2005 | Free Radic. Biol. Med. | pmid:16198231 |
| Saito A et al. | Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases. | 2005 | Bioorg. Med. Chem. | pmid:15781387 |
| Chinnici F et al. | Improved HPLC determination of phenolic compounds in cv. golden delicious apples using a monolithic column. | 2004 | J. Agric. Food Chem. | pmid:14709005 |