Procyanidin B2

Procyanidin B2 is a lipid of Polyketides (PK) class. The involved functions are known as conjugation, Methylation, Excretory function, enzyme activity and sulfatase activity. Procyanidin b2 often locates in Blood, Epidermis and Upper Gastrointestinal Tract. The associated genes with Procyanidin B2 are NR5A2 gene, HRAS wt Allele, CFB gene, PTGS2 gene and MAPK8 gene.

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Introduction

To understand associated biological information of Procyanidin B2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Procyanidin B2

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Procyanidin B2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Procyanidin B2?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Procyanidin B2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Procyanidin B2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Procyanidin B2

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Authors Title Published Journal PubMed Link
Zhang Z et al. Proteomic analysis of kidney and protective effects of grape seed procyanidin B2 in db/db mice indicate MFG-E8 as a key molecule in the development of diabetic nephropathy. 2013 Biochim. Biophys. Acta pmid:23474305
Li XL et al. PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. 2013 PLoS ONE pmid:23922881
Fukami H et al. Isolation of a reduced form of cyanidin 3-O-β-D-glucoside from immature black soybean (Glycine max (L.) Merr.) and its reducing properties. 2013 J Oleo Sci pmid:23985492
Suda M et al. Syntheses of procyanidin B2 and B3 gallate derivatives using equimolar condensation mediated by Yb(OTf)3 and their antitumor activities. 2013 Bioorg. Med. Chem. Lett. pmid:23867167
Muthenna P et al. Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. 2013 IUBMB Life pmid:24136906
Tanaka K et al. Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis. 2013 Nat Prod Commun pmid:23472464
Sung NY et al. Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23872113
Alvarez AL et al. Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds. 2012 Phytother Res pmid:22318977
Martinez-Micaelo N et al. Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. 2012 Biochem. J. pmid:21954853
Rodríguez-Ramiro I et al. Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress. 2012 Eur J Nutr pmid:22042007
Feliciano RP et al. Comparison of isolated cranberry (Vaccinium macrocarpon Ait.) proanthocyanidins to catechin and procyanidins A2 and B2 for use as standards in the 4-(dimethylamino)cinnamaldehyde assay. 2012 J. Agric. Food Chem. pmid:22533362
Zumdick S et al. In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells. 2012 Fitoterapia pmid:22776719
Ottaviani JI et al. Intake of dietary procyanidins does not contribute to the pool of circulating flavanols in humans. 2012 Am. J. Clin. Nutr. pmid:22378733
Yu F et al. Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage. 2012 PLoS ONE pmid:23285083
Shrestha SP et al. Glucuronidation and methylation of procyanidin dimers b2 and 3,3″-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver. 2012 Pharm. Res. pmid:22068277
Crupi P et al. HPLC-DAD-ESI-MS analysis of flavonoid compounds in 5 seedless table grapes grown in Apulian Region. 2012 J. Food Sci. pmid:22309436
Rodríguez-Ramiro I et al. Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. 2011 J. Nutr. Biochem. pmid:21334869
Li BY et al. Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol. 2011 Apoptosis pmid:21505870
Li BY et al. Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation. 2011 Cell Biol. Int. pmid:21244366
Kahle K et al. Intestinal transit and systemic metabolism of apple polyphenols. 2011 Eur J Nutr pmid:21184087
Poupard P et al. Characterization of procyanidin B2 oxidation products in an apple juice model solution and confirmation of their presence in apple juice by high-performance liquid chromatography coupled to electrospray ion trap mass spectrometry. 2011 J Mass Spectrom pmid:22124992
Cai Q et al. Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products. 2011 Biosci. Biotechnol. Biochem. pmid:21897042
Ramos S et al. Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells. 2011 Toxicol In Vitro pmid:21945981
Rodríguez-Ramiro I et al. Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells. 2011 Eur J Nutr pmid:21046126
Gescher K et al. Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1. 2011 Antiviral Res. pmid:21070811
Stoupi S et al. In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. 2010 Drug Metab. Dispos. pmid:19910517
Stoupi S et al. Procyanidin B2 catabolism by human fecal microflora: partial characterization of 'dimeric' intermediates. 2010 Arch. Biochem. Biophys. pmid:20188693
Stoupi S et al. A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota. 2010 Mol Nutr Food Res pmid:19943260
Chou SC et al. Influence of gallate esterification on the activity of procyanidin B2 in androgen-dependent human prostate carcinoma LNCaP cells. 2010 Pharm. Res. pmid:20162340
Cho ES et al. Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. 2009 Free Radic. Biol. Med. pmid:19248828
Appeldoorn MM et al. Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats. 2009 J. Nutr. pmid:19494022
Takeshita M et al. Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA. 2009 J. Biol. Chem. pmid:19531480
Qa'dan F et al. Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo. 2009 J Ethnopharmacol pmid:19397981
Jung M et al. Influence of apple polyphenols on inflammatory gene expression. 2009 Mol Nutr Food Res pmid:19764067
Lee KW et al. Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. 2008 Cardiovasc. Res. pmid:18310679
Xiao JS et al. Rapid preparation of procyanidins B2 and C1 from Granny Smith apples by using low pressure column chromatography and identification of their oligomeric procyanidins. 2008 J. Agric. Food Chem. pmid:18298060
Cho ES et al. Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK. 2008 Mutat. Res. pmid:18272186
Mackenzie GG et al. Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. 2008 Biochem. Pharmacol. pmid:18275936
Kang NJ et al. Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. 2008 J. Biol. Chem. pmid:18519570
Zhou DN et al. [Phenols from the rhizomes of Arachniodes exilis]. 2008 Zhong Yao Cai pmid:18619264
Hosoi S et al. Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography-mass spectrometry. 2008 J Nat Med pmid:18404300
Huang XZ et al. [Studies on chemical constituents from roots of Craibiodendron henryi]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17583200
Contreras-Domínguez M et al. Degradation of procyanidins by Aspergillus fumigatus: identification of a novel aromatic ring cleavage product. 2006 Biochimie pmid:16905239
Chen DM et al. Inhibitory effects of procyanidin B(2) dimer on lipid-laden macrophage formation. 2006 J. Cardiovasc. Pharmacol. pmid:16954822
Kamimura A et al. Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced apoptosis in hair epithelial cells: an insight into their mechanisms. 2006 Skin Pharmacol Physiol pmid:16778458
Zhang WY et al. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. 2006 Biochem. Biophys. Res. Commun. pmid:16681998
Jo JY et al. Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. 2006 J. Agric. Food Chem. pmid:16536579
Sakano K et al. Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage. 2005 Free Radic. Biol. Med. pmid:16198231
Saito A et al. Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases. 2005 Bioorg. Med. Chem. pmid:15781387
Chinnici F et al. Improved HPLC determination of phenolic compounds in cv. golden delicious apples using a monolithic column. 2004 J. Agric. Food Chem. pmid:14709005