Procyanidin B2

Procyanidin B2 is a lipid of Polyketides (PK) class. The involved functions are known as conjugation, Methylation, Excretory function, enzyme activity and sulfatase activity. Procyanidin b2 often locates in Blood, Epidermis and Upper Gastrointestinal Tract. The associated genes with Procyanidin B2 are NR5A2 gene, HRAS wt Allele, CFB gene, PTGS2 gene and MAPK8 gene.

Cross Reference

Introduction

To understand associated biological information of Procyanidin B2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Procyanidin B2

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Procyanidin B2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Procyanidin B2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Procyanidin B2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Procyanidin B2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Procyanidin B2

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Authors Title Published Journal PubMed Link
Luan SS et al. Quantitative proteomics study of protective effects of grape seed procyanidin B2 on diabetic cardiomyopathy in db/db mice. 2014 Biosci. Biotechnol. Biochem. pmid:25209507
Jeong JH et al. An investigation into the ameliorating effect of black soybean extract on learning and memory impairment with assessment of neuroprotective effects. 2014 BMC Complement Altern Med pmid:25496367
Bao L et al. Grape seed procyanidin B2 ameliorates mitochondrial dysfunction and inhibits apoptosis via the AMP-activated protein kinase-silent mating type information regulation 2 homologue 1-PPARγ co-activator-1α axis in rat mesangial cells under high-dose glucosamine. 2015 Br. J. Nutr. pmid:25404010
Zhao J et al. Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation-promotion protocol and identification of procyanidin B5-3'-gallate as the most effective antioxidant constituent. 1999 Carcinogenesis pmid:10469619
Lee KW et al. Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. 2008 Cardiovasc. Res. pmid:18310679
Li BY et al. Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation. 2011 Cell Biol. Int. pmid:21244366
Muthenna P et al. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. 2014 Chem. Biol. Interact. pmid:25199697
Shilpi A et al. Mechanisms of DNA methyltransferase-inhibitor interactions: Procyanidin B2 shows new promise for therapeutic intervention of cancer. 2015 Chem. Biol. Interact. pmid:25839702
Stoupi S et al. In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats. 2010 Drug Metab. Dispos. pmid:19910517
Kahle K et al. Intestinal transit and systemic metabolism of apple polyphenols. 2011 Eur J Nutr pmid:21184087