Procyanidin B2

Procyanidin B2 is a lipid of Polyketides (PK) class. The involved functions are known as conjugation, Methylation, Excretory function, enzyme activity and sulfatase activity. Procyanidin b2 often locates in Blood, Epidermis and Upper Gastrointestinal Tract. The associated genes with Procyanidin B2 are NR5A2 gene, HRAS wt Allele, CFB gene, PTGS2 gene and MAPK8 gene.

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Introduction

To understand associated biological information of Procyanidin B2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Procyanidin B2

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Procyanidin B2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Procyanidin B2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Procyanidin B2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Procyanidin B2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Procyanidin B2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Procyanidin B2

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Authors Title Published Journal PubMed Link
Cho ES et al. Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. 2009 Free Radic. Biol. Med. pmid:19248828
Appeldoorn MM et al. Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats. 2009 J. Nutr. pmid:19494022
Takeshita M et al. Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA. 2009 J. Biol. Chem. pmid:19531480
Qa'dan F et al. Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo. 2009 J Ethnopharmacol pmid:19397981
Lee KW et al. Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. 2008 Cardiovasc. Res. pmid:18310679
Xiao JS et al. Rapid preparation of procyanidins B2 and C1 from Granny Smith apples by using low pressure column chromatography and identification of their oligomeric procyanidins. 2008 J. Agric. Food Chem. pmid:18298060
Cho ES et al. Cocoa procyanidins protect PC12 cells from hydrogen-peroxide-induced apoptosis by inhibiting activation of p38 MAPK and JNK. 2008 Mutat. Res. pmid:18272186
Mackenzie GG et al. Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations. 2008 Biochem. Pharmacol. pmid:18275936
Kang NJ et al. Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. 2008 J. Biol. Chem. pmid:18519570
Zhou DN et al. [Phenols from the rhizomes of Arachniodes exilis]. 2008 Zhong Yao Cai pmid:18619264
Hosoi S et al. Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography-mass spectrometry. 2008 J Nat Med pmid:18404300
Huang XZ et al. [Studies on chemical constituents from roots of Craibiodendron henryi]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17583200
Contreras-Domínguez M et al. Degradation of procyanidins by Aspergillus fumigatus: identification of a novel aromatic ring cleavage product. 2006 Biochimie pmid:16905239
Chen DM et al. Inhibitory effects of procyanidin B(2) dimer on lipid-laden macrophage formation. 2006 J. Cardiovasc. Pharmacol. pmid:16954822
Kamimura A et al. Procyanidin oligomers counteract TGF-beta1- and TGF-beta2-induced apoptosis in hair epithelial cells: an insight into their mechanisms. 2006 Skin Pharmacol Physiol pmid:16778458
Zhang WY et al. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] suppresses the expression of cyclooxygenase-2 in endotoxin-treated monocytic cells. 2006 Biochem. Biophys. Res. Commun. pmid:16681998
Jo JY et al. Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. 2006 J. Agric. Food Chem. pmid:16536579
Sakano K et al. Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage. 2005 Free Radic. Biol. Med. pmid:16198231
Saito A et al. Systematic synthesis of galloyl-substituted procyanidin B1 and B2, and their ability of DPPH radical scavenging activity and inhibitory activity of DNA polymerases. 2005 Bioorg. Med. Chem. pmid:15781387
Chinnici F et al. Improved HPLC determination of phenolic compounds in cv. golden delicious apples using a monolithic column. 2004 J. Agric. Food Chem. pmid:14709005