| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang X et al. | Puerarin Attenuates Cardiac Hypertrophy Partly Through Increasing Mir-15b/195 Expression and Suppressing Non-Canonical Transforming Growth Factor Beta (Tgfβ) Signal Pathway. | 2016 | Med. Sci. Monit. | pmid:27145790 |
| Xiong N et al. | hVMAT2: A Target of Individualized Medication for Parkinson's Disease. | 2016 | Neurotherapeutics | pmid:27137201 |
| Wang Q et al. | WITHDRAWN: Puerarin injection for unstable angina pectoris. | 2016 | Cochrane Database Syst Rev | pmid:27136749 |
| Wang ZK et al. | Alleviation of Lead-Induced Apoptosis by Puerarin via Inhibiting Mitochondrial Permeability Transition Pore Opening in Primary Cultures of Rat Proximal Tubular Cells. | 2016 | Biol Trace Elem Res | pmid:27116952 |
| Yuan SY et al. | Puerarin prevents bone loss in ovariectomized mice and inhibits osteoclast formation in vitro. | 2016 | Chin J Nat Med | pmid:27114313 |
| Cheng Y et al. | Protective Effect of Puerarin Against Oxidative Stress Injury of Neural Cells and Related Mechanisms. | 2016 | Med. Sci. Monit. | pmid:27074962 |
| Saraswat G et al. | Molecular cues to the anti-implantation effect of nano-puerarin in rats. | 2016 | Reproduction | pmid:27026713 |
| Xue Q et al. | Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke. | 2016 | Int. J. Biol. Sci. | pmid:27019622 |
| Zhao J et al. | Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI). | 2017 | Mol. Neurobiol. | pmid:27013468 |
| Ma Y et al. | Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3 Expression, a Modulator of Apoptosis and Autophagy. | 2016 | Med. Sci. Monit. | pmid:27011313 |
| Luo X et al. | Puerarin Exerts a Delayed Inhibitory Effect on the Proliferation of Cardiomyocytes Derived from Murine ES Cells via Slowing Progression through G2/M Phase. | 2016 | Cell. Physiol. Biochem. | pmid:27008508 |
| Hu Y et al. | Inhibitory effect of puerarin on vascular smooth muscle cells proliferation induced by oxidised low-density lipoprotein via suppressing ERK 1/2 phosphorylation and PCNA expression. | 2016 | Pharmazie | pmid:27004373 |
| Qu H et al. | Rapid lateral-flow immunoassay for the quantum dot-based detection of puerarin. | 2016 | Biosens Bioelectron | pmid:26991602 |
| Jiang QD and Li XP | Effect of puerarin on the expression of NMU, NPY, and POMC genes in the hypothalamus. | 2016 | Genet. Mol. Res. | pmid:26985919 |
| Su HF et al. | Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms. | 2016 | Acta Pharmacol. Sin. | pmid:26972494 |
| Xu X et al. | Puerarin reduces apoptosis in rat hippocampal neurons culturea in high glucose medium by modulating the p38 mitogen activated protein kinase and c-Jun N-terminal kinase signaling pathways. | 2016 | J Tradit Chin Med | pmid:26946623 |
| Liu B et al. | Puerarin for ischaemic stroke. | 2016 | Cochrane Database Syst Rev | pmid:26891451 |
| Hong XP et al. | Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. | 2016 | J. Alzheimers Dis. | pmid:26890737 |
| Li W et al. | Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats. | 2016 | J Diabetes Res | pmid:26881260 |
| Chang BY et al. | Protective activity of kudzu (Pueraria thunbergiana) vine on chemically-induced hepatotoxicity: in vitro and in vivo studies. | 2016 | BMC Complement Altern Med | pmid:26825303 |
| Suthon S et al. | Anti-osteoporotic effects of Pueraria candollei var. mirifica on bone mineral density and histomorphometry in estrogen-deficient rats. | 2016 | J Nat Med | pmid:26815435 |
| Yang L et al. | Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling. | 2016 | Mol. Endocrinol. | pmid:26789107 |
| Qiao L et al. | A HPLC-MS/MS method for determination of 6'''-feruloylspinosin in rat plasma and tissues: Pharmacokinetics and tissue distribution study. | 2016 | J Pharm Biomed Anal | pmid:26780157 |
| Zhao YZ et al. | Using PG-Liposome-Based System to Enhance Puerarin Liver-Targeted Therapy for Alcohol-Induced Liver Disease. | 2016 | AAPS PharmSciTech | pmid:26753818 |
| Huang FJ and Chan WH | Apoptotic effects on maturation of mouse oocytes, fertilization and fetal development by puerarin. | 2016 | Drug Chem Toxicol | pmid:26712108 |
| Cheng G et al. | Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique. | 2016 | AAPS PharmSciTech | pmid:26694058 |
| Liu X et al. | Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. | 2016 | Metab Brain Dis | pmid:26686502 |
| Liu CM et al. | Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. | 2016 | Chem. Biol. Interact. | pmid:26607348 |
| Zhang H et al. | Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage. | 2015 | Biomed Res Int | pmid:26576421 |
| Wang D et al. | Automated On-Line Microdialysis Sampling Coupled with HPLC for Synchronous Determination of Puerarin in Subcutaneous Tissue and Plasma Following Topical Administration. | 2015 | Clin. Lab. | pmid:26554250 |
| Wang D et al. | Evaluation of kudzu root extract-induced hepatotoxicity. | 2015 | J Ethnopharmacol | pmid:26545459 |
| Liu S et al. | Puerarin attenuates severe burn-induced acute myocardial injury in rats. | 2015 | Burns | pmid:26514700 |
| Zhao SS et al. | Puerarin attenuates learning and memory impairments and inhibits oxidative stress in STZ-induced SAD mice. | 2015 | Neurotoxicology | pmid:26511841 |
| Wu S et al. | Study of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer. | 2015 | Molecules | pmid:26501241 |
| Zhai Y et al. | Preparation and Characterization of Puerarin-Loaded Lipid Nanocapsules. | 2015 | J Nanosci Nanotechnol | pmid:26353476 |
| Yin M et al. | Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway. | 2015 | Cell. Physiol. Biochem. | pmid:26330232 |
| Zhu X et al. | Puerarin Protects Human Neuroblastoma SH-SY5Y Cells against Glutamate-Induced Oxidative Stress and Mitochondrial Dysfunction. | 2016 | J. Biochem. Mol. Toxicol. | pmid:26277993 |
| Zhang F et al. | Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats. | 2015 | Int. Immunopharmacol. | pmid:26218281 |
| Pan X et al. | Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats. | 2015 | Med. Sci. Monit. | pmid:26201474 |
| Haque Bhuiyan MM et al. | The neuritogenic and synaptogenic effects of the ethanolic extract of radix Puerariae in cultured rat hippocampal neurons. | 2015 | J Ethnopharmacol | pmid:26196403 |
| Zhang J et al. | Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats induced by chronic ischemia. | 2015 | Int J Clin Exp Pathol | pmid:26191159 |
| Liu B et al. | Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26188094 |
| Gang C et al. | Puerarin Suppresses Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting NADPH Oxidase Activation and Oxidative Stress-Triggered AP-1 Signaling Pathways. | 2015 | J Pharm Pharm Sci | pmid:26158288 |
| Yu D et al. | Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways. | 2015 | Int. J. Mol. Med. | pmid:26101183 |
| Yi Y et al. | The construction of puerarin nanocrystals and its pharmacokinetic and in vivo-in vitro correlation (IVIVC) studies on beagle dog. | 2015 | Colloids Surf B Biointerfaces | pmid:26099971 |
| Cheng W et al. | Puerarin improves cardiac function through regulation of energy metabolism in Streptozotocin-Nicotinamide induced diabetic mice after myocardial infarction. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26079885 |
| Wenjun H et al. | The Protective Effect of Puerarin on Myocardial Infarction Reperfusion Injury (MIRI): A Meta-Analysis of Randomized Studies in Rat Models. | 2015 | Med. Sci. Monit. | pmid:26067875 |
| Sun D et al. | Simultaneous determination of acetylpuerarin and puerarin in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study following intravenous and oral administration. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26021848 |
| Zhao J et al. | Botanical Drug Puerarin Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Neurotoxicity via Upregulating Mitochondrial Enzyme Arginase-2. | 2016 | Mol. Neurobiol. | pmid:25952544 |
| Liu AC et al. | Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats. | 2015 | Chin J Nat Med | pmid:25908622 |