| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu Z et al. | Simultaneous determination of safflor yellow A, puerarin, daidzein, ginsenosides (Rg(1), Rb(1), Rd), and notoginsenoside R(1) in rat plasma by liquid chromatography-mass spectrometry. | 2007 | J Pharm Biomed Anal | pmid:17590558 |
| Li H et al. | Fragmentation study of a 8-C-glycosyl isoflavone, puerarin, using electrospray ion trap time-of-flight mass spectrometry at high resolution. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17610215 |
| Lin F et al. | Puerarin facilitates Ca(2+)-induced Ca(2+) release triggered by KCl-depolarization in primary cultured rat hippocampal neurons. | 2007 | Eur. J. Pharmacol. | pmid:17610871 |
| Xu X and Zhang Z | Effects of puerarin on synaptic structural modification in hippocampus of ovariectomized mice. | 2007 | Planta Med. | pmid:17628835 |
| Sun XH et al. | Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17652634 |
| Zhou HY et al. | [Separation and determination of puerarin, daidzin and daidzein in stems and leaves of Pueraria thomsonii by RP-HPLC]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17655152 |
| Mo SF et al. | Hypouricemic action of selected flavonoids in mice: structure-activity relationships. | 2007 | Biol. Pharm. Bull. | pmid:17666819 |
| Gao Q et al. | Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. | 2007 | Eur. J. Pharmacol. | pmid:17692311 |
| Xu X and Zheng X | Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons. | 2007 | J Ethnopharmacol | pmid:17698307 |
| Yue PF et al. | [Preparation and characterization of the puerarin submicron emulsion]. | 2007 | Yao Xue Xue Bao | pmid:17702404 |
| Li Y et al. | Comparative physicochemical characterization of phospholipids complex of puerarin formulated by conventional and supercritical methods. | 2008 | Pharm. Res. | pmid:17828444 |
| Wu L et al. | Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats. | 2007 | Phytomedicine | pmid:17870452 |
| Li DY et al. | [Clinical significance of matrix metalloproteinase-9 and tissue factors secreted by cultured monocyte-derived macrophage of patients with coronary heart disease in vitro and the intervenient effect of puerarin on them]. | 2007 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17879530 |
| Singh AK et al. | Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. | 2007 | J Med Food | pmid:17887948 |
| Cherdshewasart W and Sutjit W | Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria lobata tubers. | 2008 | Phytomedicine | pmid:17890070 |
| Xu LX et al. | Determination of 4'-methoxy-puerarin in puerarin by reversed phase HPLC. | 1991 | Yao Xue Xue Bao | pmid:1789117 |
| Cherdshewasart W and Sriwatcharakul S | Major isoflavonoid contents of the 1-year-cultivated phytoestrogen-rich herb, Pueraria mirifica. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17928711 |
| Xiao J et al. | Analysis of binding interaction between puerarin and bovine serum albumin by multi-spectroscopic method. | 2007 | J Pharm Biomed Anal | pmid:17942262 |
| Quan DQ and Xu GX | Formulation optimization of self-emulsifying preparations of puerarin through self-emulsifying performances evaluation in vitro and pharmacokinetic studies in vivo. | 2007 | Yao Xue Xue Bao | pmid:17944241 |
| Xu XH et al. | Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. | 2007 | Biomed. Environ. Sci. | pmid:17948770 |
| Chung MJ et al. | Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. | 2008 | Eur. J. Pharmacol. | pmid:17976573 |
| Yue PF et al. | Development and optimization of intravenous puerarin emulsions formation by a novel complex-phase inversion-homogenization technology. | 2007 | Chem. Pharm. Bull. | pmid:17978512 |
| Hwang YP et al. | Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. | 2007 | Arch. Pharm. Res. | pmid:18038910 |
| Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
| Zhang GW et al. | [Studies on the interaction between puerarin and bovine serum albumin]. | 2007 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:18051529 |
| He Y et al. | Binding of puerarin to human serum albumin: a spectroscopic analysis and molecular docking. | 2008 | J Fluoresc | pmid:18058205 |
| Gu YZ et al. | [Preparation of puerarin liposome and its oral absorption in rat]. | 2007 | Zhong Yao Cai | pmid:18074848 |
| Li Q et al. | [Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes]. | 2007 | Wei Sheng Yan Jiu | pmid:18095572 |
| Cherdshewasart W et al. | Determination of the estrogenic activity of wild phytoestrogen-rich Pueraria mirifica by MCF-7 proliferation assay. | 2008 | J. Reprod. Dev. | pmid:18160771 |
| Yang H et al. | [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161289 |
| Liu R et al. | [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161305 |
| Yue PF et al. | The study to reduce the hemolysis side effect of puerarin by a submicron emulsion delivery system. | 2008 | Biol. Pharm. Bull. | pmid:18175940 |
| Tian YX et al. | Radical dynamics of puerarin as revealed by laser flash photolysis and spin density analysis. | 2008 | J Phys Chem B | pmid:18232684 |
| Lu Y et al. | [Pharmacokinetics of pueraria for intranasal on spray in rabbits]. | 2007 | Zhong Yao Cai | pmid:18236755 |
| Wang Q et al. | Quantification of puerarin in plasma by on-line solid-phase extraction column switching liquid chromatography-tandem mass spectrometry and its applications to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18242154 |
| Tan Y et al. | Puerarin for acute ischaemic stroke. | 2008 | Cochrane Database Syst Rev | pmid:18254067 |
| Wang Z et al. | Study on the interaction of puerarin with lysozyme by spectroscopic methods. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:18262462 |
| Zhu Z et al. | Effects of puerarin on pulmonary vascular remodeling and protein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats. | 2008 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:18278451 |
| Cherdshewasart W and Sriwatcharakul S | Metabolic activation promotes estrogenic activity of the phytoestrogen-rich plant. | 2008 | Maturitas | pmid:18313242 |
| Ding MP et al. | [Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330247 |
| Guo Y et al. | [Study on effect of different combinations of traditional Chinese medicine preparation active parts on metabolism of puerarin in plasma of rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330251 |
| Zhang SY et al. | The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction. | 2008 Mar-Apr | J Asian Nat Prod Res | pmid:18348063 |
| Wang Y et al. | Preventive effects of puerarin on alcohol-induced osteonecrosis. | 2008 | Clin. Orthop. Relat. Res. | pmid:18350350 |
| Chen JW et al. | [Molecular mechanism of reversing multi-drug resistance of K562/AO2 by puerarin]. | 2008 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:18382055 |
| He H et al. | The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2008 | Phytother Res | pmid:18389490 |
| Yue PF et al. | Preparation, characterization, and pharmacokinetic evaluation of puerarin submicron emulsion. | 2008 Jan-Feb | PDA J Pharm Sci Technol | pmid:18402366 |
| Huang J et al. | Selective adsorption of tannin from flavonoids by organically modified attapulgite clay. | 2008 | J. Hazard. Mater. | pmid:18433994 |
| Chang Q et al. | Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high-performance liquid chromatography. | Phytochem Anal | pmid:18438756 | |
| Li Y et al. | Process parameters and morphology in puerarin, phospholipids and their complex microparticles generation by supercritical antisolvent precipitation. | 2008 | Int J Pharm | pmid:18440736 |
| Clarke DB et al. | Determination of phytoestrogens in dietary supplements by LC-MS/MS. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:18478479 |