| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kong H et al. | Effect of Puerarin on the Pharmacokinetics of Baicalin in Gegen Qinlian Decoction () in Mice. | 2018 | Chin J Integr Med | pmid:25908218 |
| Lv H et al. | Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway. | 2015 | Mol Med Rep | pmid:25892538 |
| Zou ZJ et al. | Intervention effects of puerarin on blood stasis in rats revealed by a (1)H NMR-based metabonomic approach. | 2015 | Phytomedicine | pmid:25837270 |
| Cui SQ et al. | Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. | 2015 | Braz. J. Med. Biol. Res. | pmid:25831201 |
| Gray SL et al. | Impact of kudzu and puerarin on sperm function. | 2015 | Reprod. Toxicol. | pmid:25828059 |
| Zheng G et al. | Effects of puerarin on lipid accumulation and metabolism in high-fat diet-fed mice. | 2015 | PLoS ONE | pmid:25822741 |
| Han P et al. | Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells. | 2015 | Life Sci. | pmid:25817234 |
| Wang Z et al. | Protective effects of edaravone combined puerarin on inhalation lung injury induced by black gunpowder smog. | 2015 | Int. Immunopharmacol. | pmid:25754765 |
| Zhang Y et al. | The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression. | 2015 | Ren Fail | pmid:25707518 |
| Yang X et al. | Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis. | 2015 | J. Periodont. Res. | pmid:25645818 |
| Kang OH et al. | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Int. J. Mol. Med. | pmid:25605057 |
| Zhu X et al. | The effect of puerarin against IL-1β-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). | 2014 | Mol. Vis. | pmid:25593509 |
| Qu J et al. | Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression. | 2015 | J. Neurol. Sci. | pmid:25592416 |
| Li B et al. | Puerarin enhances bone mass by promoting osteoblastogenesis and slightly lowering bone marrow adiposity in ovariectomized rats. | 2014 | Biol. Pharm. Bull. | pmid:25590084 |
| Guo HD et al. | Large scale purification of puerarin from Puerariae Lobatae Radix through resins adsorption and acid hydrolysis. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25553536 |
| Wang X et al. | De novo transcriptome sequencing in Pueraria lobata to identify putative genes involved in isoflavones biosynthesis. | 2015 | Plant Cell Rep. | pmid:25547742 |
| Wang J et al. | Puerarin attenuates airway inflammation by regulation of eotaxin-3. | 2015 | Immunol. Lett. | pmid:25530546 |
| Hou JY et al. | Mucoadhesive microparticles for gastroretentive delivery: preparation, biodistribution and targeting evaluation. | 2014 | Mar Drugs | pmid:25470180 |
| Tiyasatkulkovit W et al. | Pueraria mirifica extract and puerarin enhance proliferation and expression of alkaline phosphatase and type I collagen in primary baboon osteoblasts. | 2014 | Phytomedicine | pmid:25442257 |
| Guo XF et al. | Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma. | 2015 | Mol Med Rep | pmid:25434307 |
| Liang XL et al. | Mechanisms of improvement of intestinal transport of baicalin and puerarin by extracts of Radix Angelicae Dahuricae. | 2015 | Phytother Res | pmid:25312586 |
| Zhao J et al. | Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1/2 and PI3K/Akt signaling pathways in the neurite extension process. | 2015 | CNS Neurosci Ther | pmid:25310912 |
| Wang P et al. | Rapid determination of major bioactive isoflavonoid compounds during the extraction process of kudzu (Pueraria lobata) by near-infrared transmission spectroscopy. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25310261 |
| Tian F et al. | The neuroprotective mechanism of puerarin in the treatment of acute spinal ischemia-reperfusion injury is linked to cyclin-dependent kinase 5. | 2015 | Neurosci. Lett. | pmid:25301568 |
| Jung HR et al. | Simultaneous determination of puerarin and its active metabolite in human plasma by UPLC-MS/MS: application to a pharmacokinetic study. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25264914 |
| Zhang X et al. | Puerarin protects dopaminergic neurons in Parkinson's disease models. | 2014 | Neuroscience | pmid:25218963 |
| Fu R et al. | Digital gene expression analysis of the pathogenesis and therapeutic mechanisms of ligustrazine and puerarin in rat atherosclerosis. | 2014 | Gene | pmid:25218235 |
| Kim MH et al. | Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease. | 2014 | Planta Med. | pmid:25210998 |
| Kim M et al. | Deglycosylation of isoflavone C-glycosides by newly isolated human intestinal bacteria. | 2015 | J. Sci. Food Agric. | pmid:25199800 |
| Li C et al. | Puerarin induces the upregulation of glutathione levels and nuclear translocation of Nrf2 through PI3K/Akt/GSK-3β signaling events in PC12 cells exposed to lead. | Neurotoxicol Teratol | pmid:25195717 | |
| Wang J et al. | Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer. | 2014 | Mol Med Rep | pmid:25189132 |
| Wu J et al. | Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials. | 2014 | J Tradit Chin Med | pmid:25185357 |
| Zhang WG et al. | Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells. | 2014 | Mol Med Rep | pmid:25175767 |
| Gan M and Yin X | Puerarin induced in mantle cell lymphoma apoptosis and its possible mechanisms involving multi-signaling pathway. | 2015 | Cell Biochem. Biophys. | pmid:25173778 |
| Wang C et al. | Puerarin protects against β-amyloid-induced microglia apoptosis via a PI3K-dependent signaling pathway. | 2014 | Neurochem. Res. | pmid:25173404 |
| Xie N et al. | Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms. | 2014 | Cell. Mol. Neurobiol. | pmid:25151533 |
| Zhang JQ and Zhou YP | [Inhibition of aldose reductase from rat lens by some Chinese herbs and their components]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2511877 |
| Liu M et al. | Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord. | 2014 | Mediators Inflamm. | pmid:25089076 |
| Wang L et al. | Puerarin facilitates T-tubule development of murine embryonic stem cell-derived cardiomyocytes. | 2014 | Cell. Physiol. Biochem. | pmid:25059232 |
| Maji AK et al. | Pueraria tuberosa: a review on its phytochemical and therapeutic potential. | 2014 | Nat. Prod. Res. | pmid:24980468 |
| Ma JQ et al. | Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. | 2014 | Food Chem. Toxicol. | pmid:24975872 |
| Wang C et al. | The proliferation, differentiation, and mineralization effects of puerarin on osteoblasts in vitro. | 2014 | Chin J Nat Med | pmid:24969524 |
| Wei SY et al. | Progress on the pharmacological research of puerarin: a review. | 2014 | Chin J Nat Med | pmid:24969520 |
| Park WS et al. | Anti-graying effect of the extract of Pueraria thunbergiana via upregulation of cAMP/MITF-M signaling pathway. | 2014 | J. Dermatol. Sci. | pmid:24924521 |
| Guo YJ et al. | In vivo inhibitory effects of puerarin on selected rat cytochrome P450 isoenzymes. | 2014 | Pharmazie | pmid:24855829 |
| Wang Y et al. | Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-κB ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells. | Phytomedicine | pmid:24854571 | |
| Li Z et al. | Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. | 2014 | J. Mol. Endocrinol. | pmid:24827001 |
| Qu Q et al. | Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro. | 2014 | Acta Pharmacol. Sin. | pmid:24786236 |
| Yu P et al. | Determination of puerarin in rat plasma using PEGylated magnetic carbon nanotubes by high performance liquid chromatography. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24768919 |
| Liao ZG et al. | Transport properties of puerarin and effect of extract of Radix Angelicae dahuricae on puerarin intestinal absorption using in situ and in vitro models. | 2014 | Phytother Res | pmid:24756954 |