| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang XC et al. | [Effect of chaperone-mediated autophagy in MPP(+) -induced SH-SY5Y cells and interventional effect of puerarin]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24754178 |
| Shao J et al. | Spectroscopic and molecular docking studies of the in vitro interaction between puerarin and cytochrome P450. | 2014 | Molecules | pmid:24743933 |
| Wu M et al. | Effects of delayed puerarin treatment in long-term neurological outcomes of focal ischemic stroke in rats. | 2014 Mar-Apr | Indian J Pharmacol | pmid:24741185 |
| Liu Y et al. | Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin. | 2014 | Int. J. Biol. Sci. | pmid:24719562 |
| Kim SB et al. | In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism. | 2014 | Planta Med. | pmid:24710899 |
| Bao MH et al. | Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24708212 |
| Lu Q et al. | Puerarin attenuates calcification of vascular smooth muscle cells. | 2014 | Am. J. Chin. Med. | pmid:24707866 |
| Ma JQ et al. | Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24698568 |
| Lu XL et al. | Protective effects of puerarin against Aß40-induced vascular dysfunction in zebrafish and human endothelial cells. | 2014 | Eur. J. Pharmacol. | pmid:24690262 |
| Li H et al. | Comparison of two approaches of intestinal absorption by puerarin. | J Pharmacol Toxicol Methods | pmid:24674709 | |
| Zhu H et al. | Effect of puerarin on matrix metalloproteinase-2 in human fetal scleral fibroblasts treated with low frequency electromagnetic fields. | 2013 | J Tradit Chin Med | pmid:24660593 |
| Liu S et al. | Puerarin alleviates aggravated sympathoexcitatory response induced by myocardial ischemia via regulating P2X3 receptor in rat superior cervical ganglia. | 2014 | Neurochem. Int. | pmid:24657446 |
| Yan Y et al. | Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. | 2014 | J Pharm Biomed Anal | pmid:24637051 |
| Wang S et al. | Efficient glycosylation of puerarin by an organic solvent-tolerant strain of Lysinibacillus fusiformis. | 2014 | Enzyme Microb. Technol. | pmid:24629266 |
| Chen G et al. | Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways. | 2014 | Acta Pharmacol. Sin. | pmid:24608673 |
| Li H et al. | Biopharmaceutics classification of puerarin and comparison of perfusion approaches in rats. | 2014 | Int J Pharm | pmid:24607203 |
| Yang S et al. | Protective effects of puerarin against tetrabromobisphenol a-induced apoptosis and cardiac developmental toxicity in zebrafish embryo-larvae. | 2015 | Environ. Toxicol. | pmid:24596333 |
| She S et al. | Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. | 2014 | Food Funct | pmid:24595557 |
| Mahdy HM et al. | The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24593790 |
| Qu H et al. | Development of an enzyme-linked immunosorbent assay based on anti-puerarin monoclonal antibody and its applications. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24583873 |
| Bao L et al. | The anti-atherosclerotic effects of puerarin on induced-atherosclerosis in rabbits. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:24510110 |
| Liu G et al. | Puerarin protects against lead-induced cytotoxicity in cultured primary rat proximal tubular cells. | 2014 | Hum Exp Toxicol | pmid:24505050 |
| Tang L et al. | The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. | 2014 | Cell Biochem. Funct. | pmid:24496955 |
| Xu J et al. | A new flavonoid glycoside from the rhizomes and roots of Smilax scobinicaulis. | 2014 | Nat. Prod. Res. | pmid:24483603 |
| Liao D et al. | N-trimethyl chitosan (TMC)-modified microemulsions for improved oral bioavailability of puerarin: preparation and evaluation. | 2015 | Drug Deliv | pmid:24467620 |
| Zhong Y et al. | Puerarin attenuated early diabetic kidney injury through down-regulation of matrix metalloproteinase 9 in streptozotocin-induced diabetic rats. | 2014 | PLoS ONE | pmid:24454919 |
| Liu S et al. | Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial ischemic damage. | 2014 | Brain Res. Bull. | pmid:24447636 |
| Tang F et al. | Puerarin protects against Staphylococcus aureus-induced injury of human alveolar epithelial A549 cells via downregulating alpha-hemolysin secretion. | 2014 | Microb. Drug Resist. | pmid:24372183 |
| Liu AC et al. | LC-MS/MS method for the determination of a new puerarin derivative and its application in pharmacokinetic studies in rats. | 2013 | Chin J Nat Med | pmid:24359785 |
| Mahdy HM et al. | Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms. | 2014 | Neurochem. Res. | pmid:24346712 |
| Zhou Y et al. | Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24345484 |
| Zhou YX et al. | Puerarin: a review of pharmacological effects. | 2014 | Phytother Res | pmid:24339367 |
| Wang N et al. | Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. | 2014 | Neuropharmacology | pmid:24333675 |
| Tang TT et al. | Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach. | 2013 | Int J Nanomedicine | pmid:24277986 |
| Liu Q et al. | MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate. | 2014 | Pharm. Res. | pmid:24242937 |
| Singh AK et al. | Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. | 2013 | J Med Food | pmid:24138167 |
| Cui YH et al. | [Adsorption and isolation of macroporous resin for three isoflavonoids from puerariae lobatae radix]. | 2013 | Zhong Yao Cai | pmid:24134015 |
| Wang Y et al. | Simultaneous determination of four components in Baige capsule by HPLC: application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. | 2014 | Biomed. Chromatogr. | pmid:24122939 |
| Liu Y et al. | Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways. | 2014 | Chin J Integr Med | pmid:24122632 |
| Tu L et al. | Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat. | 2013 | Int J Pharm | pmid:24120729 |
| Cheng Y et al. | Effects of puerarin on cardiac differentiation and ventricular specialization of murine embryonic stem cells. | 2013 | Cell. Physiol. Biochem. | pmid:24080853 |
| Wang JW et al. | Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. | 2014 | J. Surg. Res. | pmid:24079811 |
| Zhou A et al. | Lymphatic transport of puerarin occurs after oral administration of different lipid-based formulations to unconscious lymph duct-cannulated rats. | 2014 | Pharm Dev Technol | pmid:23978005 |
| Wu X et al. | Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23948238 |
| Wu K et al. | Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23927877 |
| Ji M et al. | Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α. | 2013 | J. Steroid Biochem. Mol. Biol. | pmid:23907019 |
| Yuan Y et al. | Puerarin attenuates pressure overload-induced cardiac hypertrophy. | 2014 | J Cardiol | pmid:23906530 |
| Zhao LX et al. | The permeability of puerarin loaded poly(butylcyanoacrylate) nanoparticles coated with polysorbate 80 on the blood-brain barrier and its protective effect against cerebral ischemia/reperfusion injury. | 2013 | Biol. Pharm. Bull. | pmid:23902970 |
| Xu L et al. | Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect. | 2013 | Phytomedicine | pmid:23856441 |
| Cheng M et al. | Puerarin accelerates re-endothelialization in a carotid arterial injury model: impact on vasodilator concentration and vascular cell functions. | 2013 | J. Cardiovasc. Pharmacol. | pmid:23792702 |