| MeSH term | MeSH ID | Detail |
|---|---|---|
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Deng Y et al. | Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery. | 2012 | J Ethnopharmacol | pmid:22120017 |
| Chen X et al. | [Study on pharmacokinetics of puerarin in rats following different methods of administration of Tongqiao Sanyu prescription]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22121800 |
| Zhang Q et al. | Puerarin protects differentiated PC12 cells from Hâ‚‚Oâ‚‚-induced apoptosis through the PI3K/Akt signalling pathway. | 2012 | Cell Biol. Int. | pmid:22126839 |
| Lipovac M et al. | Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. | 2011 | Obstet Gynecol Int | pmid:22135679 |
| Zhang XP et al. | Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis. | 2011 | HBPD INT | pmid:22146628 |
| Liu CM et al. | Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22172631 |
| Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
| Zeng A et al. | Simultaneous analysis and retention behavior of major isoflavonoids in Radix Puerariae lobatae and Radix Puerariae thomsonii by high performance liquid chromatography with cyclodextrins as a mobile phase modifier. | 2012 | Anal. Chim. Acta | pmid:22177078 |
| Cui SQ | [Effect of puerarin in myocardial protection in rats with acute and chronic alcoholism]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22200707 |
| Song JX et al. | Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? | 2012 | J Ethnopharmacol | pmid:22212501 |
| Zheng GM et al. | Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation. | 2012 | Int. J. Oncol. | pmid:22246431 |
| Li Y et al. | Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats. | 2012 | Biomed. Chromatogr. | pmid:22253022 |
| Wu Y et al. | Optimisation of ultrasound-assisted extraction of puerarin and total isoflavones from Puerariae Lobatae Radix (Pueraria lobata (Wild.) Ohwi) with response surface methodology. | 2012 Sep-Oct | Phytochem Anal | pmid:22259187 |
| Zhu G et al. | Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. | 2012 | Neurochem. Int. | pmid:22265823 |
| Lin F et al. | Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. | 2012 | Arzneimittelforschung | pmid:22278629 |
| Pan ZJ et al. | [Effects of puerarin on blood pressure, blood lipid and renal structure of cold-induced hypertensive mice]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22295519 |
| Gu L et al. | Polyamidomine dendrimers: an excellent drug carrier for improving the solubility and bioavailability of puerarin. | 2013 Sep-Oct | Pharm Dev Technol | pmid:22303809 |
| Huang F et al. | Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner. | 2012 | Biochimie | pmid:22314193 |
| Tang XL et al. | Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22333267 |
| Hou Q et al. | [Puerarin combined with avandia for diabetic nephropathy]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22349389 |
| Chen C et al. | [Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia]. | 2011 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22357486 |
| Liu L et al. | Determination of puerarin in pharmaceutical and biological samples by capillary zone electrophoresis with UV detection. | 2012 | Talanta | pmid:22365684 |
| Zhang Y et al. | Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery. | 2012 | Int J Pharm | pmid:22366381 |
| Yang F et al. | Osteoblast response to puerarin-loaded porous titanium surfaces: an in vitro study. | 2012 | J Biomed Mater Res A | pmid:22374837 |
| Zhang H et al. | Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. | 2012 | J Phys Chem B | pmid:22376204 |
| Gomuttapong S et al. | Testing of the estrogenic activity and toxicity of Stephania venosa herb in ovariectomized rats. | 2012 | Toxicol. Mech. Methods | pmid:22394346 |
| Yao XJ et al. | Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages. | 2012 | J Ethnopharmacol | pmid:22401764 |
| Cho HJ et al. | Acute effect of high-dose isoflavones from Pueraria lobata (Willd.) Ohwi on lipid and bone metabolism in ovariectomized mice. | 2012 | Phytother Res | pmid:22422661 |
| Zheng GH et al. | Systematic Review of Chinese Herbal Medicines for Preventing in-Stent Coronary Restenosis after Percutaneous Coronary Intervention. | 2012 | Evid Based Complement Alternat Med | pmid:22454659 |
| Fan R et al. | Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application. | 2012 | Evid Based Complement Alternat Med | pmid:22454671 |
| Zhang MY et al. | In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. | 2012 | Chin J Integr Med | pmid:22457138 |
| Pang W et al. | Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. | 2012 | Chin J Integr Med | pmid:22457139 |
| Zhao Y and Zhou Y | Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. | 2012 | Chin J Integr Med | pmid:22457141 |
| Chen C et al. | Puerarin induces mitochondria-dependent apoptosis in hypoxic human pulmonary arterial smooth muscle cells. | 2012 | PLoS ONE | pmid:22457823 |
| Liang J et al. | Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats. | 2012 | Mol Med Rep | pmid:22470138 |
| Coghlan ML et al. | Deep sequencing of plant and animal DNA contained within traditional Chinese medicines reveals legality issues and health safety concerns. | 2012 | PLoS Genet. | pmid:22511890 |
| Hao LN et al. | Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. | 2012 | Sheng Li Xue Bao | pmid:22513471 |
| Qiu Y et al. | Traditional chinese herbal products for coronary heart disease: an overview of cochrane reviews. | 2012 | Evid Based Complement Alternat Med | pmid:22536282 |
| Ho FM et al. | Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. | 2012 | J Ethnopharmacol | pmid:22543166 |
| Jiang H et al. | Natural product nitric oxide chemistry: new activity of old medicines. | 2012 | Evid Based Complement Alternat Med | pmid:22548122 |
| Wang J and Xiong X | Current situation and perspectives of clinical study in integrative medicine in china. | 2012 | Evid Based Complement Alternat Med | pmid:22550539 |
| Hao LN et al. | Effect of puerarin on retinal pigment epithelial cells apoptosis induced partly by peroxynitrite via Fas/FasL pathway. | 2010 | Int J Ophthalmol | pmid:22553574 |
| Hao LN et al. | Toxicity of endogenous peroxynitrite and effects of puerarin on transplanted retinal pigment epithelial sheets in the subretinal space in mice. | 2011 | Int J Ophthalmol | pmid:22553655 |
| Luo J et al. | Molecularly imprinted layer-coated monodisperse spherical silica microparticles toward affinity-enrichment of isoflavonoid glycosides from Radix puerariae. | 2012 | Analyst | pmid:22553769 |
| Chauhan SK et al. | Determination of puerarin from pueraria tuberosa dc by HPLC. | 2004 | Anc Sci Life | pmid:22557128 |
| Penetar DM et al. | The isoflavone puerarin reduces alcohol intake in heavy drinkers: a pilot study. | 2012 | Drug Alcohol Depend | pmid:22578529 |
| Yan F et al. | Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. | 2012 | J Pharm Pharm Sci | pmid:22579001 |
| Zhao X et al. | Simultaneous determination of six isoflavonoids in rat plasma after administration of total flavonoid from Gegen by ultra-HPLC-MS/MS. | 2012 | J Sep Sci | pmid:22589159 |
| Xie J et al. | Improvement in solubility and bioavailability of puerarin by mechanochemical preparation. | 2013 | Drug Dev Ind Pharm | pmid:22591175 |
| Luo J and Xu H | Outcome measures of chinese herbal medicine for coronary heart disease: an overview of systematic reviews. | 2012 | Evid Based Complement Alternat Med | pmid:22606207 |
| Kim J et al. | Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22609359 |
| Jin SE et al. | Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. | 2012 | Arch. Pharm. Res. | pmid:22644850 |
| Luo CF et al. | UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. | 2012 | Arch. Toxicol. | pmid:22648071 |
| Wang R et al. | [Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22686089 |
| Yu N et al. | The effects of sperminated pullulans on cornea permeability to puerarin and the toxicity. | 2012 | J Ocul Pharmacol Ther | pmid:22690870 |
| Han J et al. | [Study on 3'-methoxy puerarin to dynamic changes of amino acids in rat brain ischemia-reperfusion]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792810 |
| Huang MQ et al. | [Puerarin inhibits DNA damage of HaCaT cells induced by UVB via ceramide pathway]. | 2012 | Yao Xue Xue Bao | pmid:22812004 |
| Ko JA et al. | Enzymatic synthesis of puerarin glucosides using Leuconostoc dextransucrase. | 2012 | J. Microbiol. Biotechnol. | pmid:22814496 |
| Deng L et al. | [Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860464 |
| Liang X et al. | [Intestinal absorption effect of Angelica dahurica extract on puerarin of puerariae Lobatae Radix]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860465 |
| Zeng X et al. | Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution. | 2012 | J Colloid Interface Sci | pmid:22878002 |
| Michihara S et al. | Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway. | 2012 | J. Nutr. Sci. Vitaminol. | pmid:22878391 |
| Luo ZK et al. | [A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection]. | 2012 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:22883272 |
| Wang PP et al. | Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways. | 2012 | J Asian Nat Prod Res | pmid:22917468 |
| Saha P et al. | Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage. | 2012 | Reproduction | pmid:22919047 |
| Zhao R et al. | NMR studies on puerarin and its interaction with beta-cyclodextrin. | 2011 | J Biol Phys | pmid:22942483 |
| Tiyasatkulkovit W et al. | Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica. | 2012 | Phytomedicine | pmid:22951392 |
| Wang Y et al. | Formulation and pharmacokinetics evaluation of puerarin nanocrystals for intravenous delivery. | 2012 | J Nanosci Nanotechnol | pmid:22962724 |
| Fan JP et al. | Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology. | 2012 | Food Chem | pmid:22980805 |
| Wang Q et al. | [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22994007 |
| Cheng W et al. | Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA. | 2012 | PLoS ONE | pmid:23029074 |
| Zhang J et al. | Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. | 2013 | Burns | pmid:23044342 |
| Sheu SY et al. | Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice. | 2012 | Chin. Med. J. | pmid:23075718 |
| Liang XL et al. | Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. | 2012 | J Ethnopharmacol | pmid:23085309 |
| Zou Y et al. | Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. | 2013 | Free Radic. Res. | pmid:23088308 |
| Wang Y et al. | In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. | 2013 | Int J Pharm | pmid:23089583 |
| Prasain JK et al. | The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. | 2012 | Phytomedicine | pmid:23123226 |
| Yin R et al. | UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. | 2013 | J Pharm Biomed Anal | pmid:23146236 |
| Li R et al. | Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23146695 |
| Chen F et al. | Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. | 2012 | Asian Pac J Trop Med | pmid:23146804 |
| Han JQ et al. | [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:23173255 |
| Tao HQ et al. | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23192284 |
| Liu B et al. | Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. | 2012 | J. Agric. Food Chem. | pmid:23215052 |
| Wang X et al. | Identification and assay of 3'-O-methyltaxifolin by UPLC-MS in rat plasma. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23217303 |
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| Sun XY et al. | [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. | 2012 | Zhong Yao Cai | pmid:23236837 |
| Wang Q et al. | Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23246846 |
| Deng Y et al. | [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23270242 |
| Peng JH et al. | Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23277536 |
| Hu JJ et al. | [Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23311164 |
| Jiang L et al. | Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23314488 |
| Wang L et al. | Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. | 2013 | Hum Exp Toxicol | pmid:23315276 |
| Nakamura K et al. | Enzymatic cleavage of the C-glucosidic bond of puerarin by three proteins, Mn(2+), and oxidized form of nicotinamide adenine dinucleotide. | 2013 | Biol. Pharm. Bull. | pmid:23328408 |
| Liu XY et al. | [Stability of PEGylated puerarin under different storage conditions]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23373208 |
| Zhang BS et al. | [Cellular absorption of the active ingredients in different compatibilities of gegenqinlian decoction in human intestinal Caco-2 cells]. | 2012 | Zhong Yao Cai | pmid:23451503 |
| An R et al. | [Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ]. | 2012 | Yao Xue Xue Bao | pmid:23460978 |
| Luo CF et al. | Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. | 2013 | Int J Nanomedicine | pmid:23486407 |
| Cao L et al. | Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. | 2013 | Fitoterapia | pmid:23500385 |
| Guo C et al. | Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. | 2013 | Food Chem. Toxicol. | pmid:23500774 |
| Liu CM et al. | Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase. | 2013 | Environ. Toxicol. Pharmacol. | pmid:23501611 |