SCHEMBL105486

Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with SCHEMBL105486?

SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with SCHEMBL105486

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Lead Poisoning D007855 4 associated lipids
Adenocarcinoma D000230 166 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Arthritis D001168 41 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Endometriosis D004715 29 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with SCHEMBL105486

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with SCHEMBL105486?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with SCHEMBL105486?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with SCHEMBL105486?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with SCHEMBL105486?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with SCHEMBL105486?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with SCHEMBL105486

Download all related citations
Per page 10 20 50 100 | Total 919
Authors Title Published Journal PubMed Link
Li Y et al. Effect of puerarin on collagen metabolism of fibroblasts in pelvic tissue of women with pelvic organ prolapse. 2018 Mol Med Rep pmid:29207080
Zhong Y et al. Puerarin alleviate radicular pain from lumbar disc herniation by inhibiting ERK-dependent spinal microglia activation. 2018 Neuropeptides pmid:30466510
Li SW et al. Comparison on Anticoagulation and Antiplatelet Aggregation Effects of Puerarin with Heparin Sodium and Tirofiban Hydrochloride: An In Vitro Study. 2018 Chin J Integr Med pmid:29067595
Chen X et al. Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor. 2018 Eur. J. Pharmacol. pmid:29061371
Ling C et al. Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 2018 Molecules pmid:29498696
Liu X et al. Puerarin Inhibits Proliferation and Induces Apoptosis by Upregulation of miR-16 in Bladder Cancer Cell Line T24. 2018 Oncol. Res. pmid:29422113
Wang HQ et al. Puerarin Up-regulates Methyl-CpG Binding Protein 2 Phosphorylation in Hippocampus of Vascular Dementia Rats. 2018 Chin J Integr Med pmid:29327124
Zhao Q et al. Effects of glycyrrhizin on the pharmacokinetics of puerarin in rats. 2018 Xenobiotica pmid:29099639
Liu B et al. Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis. 2018 Biochem. Biophys. Res. Commun. pmid:29427658
Kong H et al. Effect of Puerarin on the Pharmacokinetics of Baicalin in Gegen Qinlian Decoction () in Mice. 2018 Chin J Integr Med pmid:25908218