SCHEMBL105486

Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with SCHEMBL105486?

SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with SCHEMBL105486

MeSH term MeSH ID Detail
Alcohol-Related Disorders D019973 3 associated lipids
Urinary Incontinence D014549 4 associated lipids
Lead Poisoning D007855 4 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Dyspepsia D004415 5 associated lipids
Hypertension, Renovascular D006978 10 associated lipids
Amnesia D000647 12 associated lipids
Glucose Intolerance D018149 13 associated lipids
Angina, Unstable D000789 14 associated lipids
Brain Infarction D020520 17 associated lipids
Angina Pectoris D000787 27 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Endometriosis D004715 29 associated lipids
Stroke D020521 32 associated lipids
Memory Disorders D008569 33 associated lipids
Burns D002056 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Cataract D002386 34 associated lipids
Fever D005334 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Per page 10 20 50 | Total 43

PubChem Associated disorders and diseases

What pathways are associated with SCHEMBL105486

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with SCHEMBL105486?

Related references are published most in these journals:

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What functions are associated with SCHEMBL105486?


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Function Cross reference Weighted score Related literatures

What lipids are associated with SCHEMBL105486?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with SCHEMBL105486?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with SCHEMBL105486?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with SCHEMBL105486

Download all related citations
Per page 10 20 50 100 | Total 919
Authors Title Published Journal PubMed Link
Li QX et al. [Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats]. 2008 Zhonghua Yu Fang Yi Xue Za Zhi pmid:18763636
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Hao LN et al. [The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells]. 2008 Zhonghua Yan Ke Za Zhi pmid:18683704
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Ji O et al. [Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. 2013 Zhonghua Xue Ye Xue Za Zhi pmid:23688762
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Han P et al. [Potential antiviral drug Pueraria crude extract and puerarin protect against ethanol-induced cytotoxicity in embryonic mouse hippocampal cultures]. 2005 Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi pmid:16261207
Luo ZK et al. [A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection]. 2012 Zhonghua Liu Xing Bing Xue Za Zhi pmid:22883272
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Xu HX et al. [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. 2011 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:21418943
Wang C et al. [Therapeutic effect of puerarin on rats with pre-eclampsia]. 2006 Zhonghua Fu Chan Ke Za Zhi pmid:16640862
Feng CG et al. [Progress in research of aldose reductase inhibitors in traditional medicinal herbs]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16335816
Ma YS et al. [Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12512448
Jin WS et al. [Determination of puerarin, daidzin and daidzein in root of Pueraria lobata of different origin by HPLC]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15015267
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Pan HP et al. [Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011103
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Su B et al. [Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy]. 2011 Zhongguo Zhong Yao Za Zhi pmid:21710725
Xu YZ et al. [Puerarin suppresses the proliferation of vscular smooth muscule cells and c-fos and bcl-2 protein expression]. 2006 Zhongguo Zhong Yao Za Zhi pmid:16722382
Wang FW et al. [Protective effect of puerarin on stress-induced gastric mucosal injury in rats]. 2006 Zhongguo Zhong Yao Za Zhi pmid:16722386
Wang Y et al. [Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18533503
Zhang YB et al. [Protective effects of 3'-methoxy-puerarin on rat brain suffering from ischemia]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18536378
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Wu GL et al. [Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19166018
Jing L and Gao ZY [Retrospective analysis on Chinese medicinal treatment on 302 chronic heart failure patients of coronary heart disease and diabetes]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19166020
Han J et al. [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats]. 2009 Zhongguo Zhong Yao Za Zhi pmid:19771877
Chen R et al. [Simultaneous quantification of five impurities in puerarin and its injections by HPLC method with correction factor]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22032137
Liu Y et al. [Corneal penetration of PAMAM dendrimers-coated puerarin liposomes]. 2010 Zhongguo Zhong Yao Za Zhi pmid:20349711
Zhang D et al. [Isoflavones from vines of Pueraria lobata]. 2009 Zhongguo Zhong Yao Za Zhi pmid:20353004
Jin G et al. [Effects of puerarin on expression of apelin and its receptor of 2K1C renal hypertension rats]. 2009 Zhongguo Zhong Yao Za Zhi pmid:20353015
Huang ZG et al. [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23668014
Deng Y et al. [Preparation and lacrimal pharmacokinetics of eye drops of puerarin liposomes in rabbit tears]. 2010 Zhongguo Zhong Yao Za Zhi pmid:20422993
He D et al. [Improvement of solubility of puerarin through deoxycholate/phospholipid mixed micelle preparing technology]. 2010 Zhongguo Zhong Yao Za Zhi pmid:20822006
Xue C et al. [Determination of five components in Pueraria labta decoction with reference extraction method]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23234135
Hu JJ et al. [Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23311164
Wang Q and Xu X [Progresses in research of hemolysis induced by puerarin injection]. 2011 Zhongguo Zhong Yao Za Zhi pmid:21837990
Cheng Y et al. [Protective effects of puerarin against 1-methyl-4-phenylpyridinium-induced mitochondrial apoptotic death in differentiated SH-SY5Y cells]. 2011 Zhongguo Zhong Yao Za Zhi pmid:21842654
Yu S et al. [Comparison of constituents in Pueraria thomsonii Benth before and after processing]. 1992 Zhongguo Zhong Yao Za Zhi pmid:1292491
Zhou Y et al. [Comparative study on pharmacological effects of various species of Pueraria]. 1995 Zhongguo Zhong Yao Za Zhi pmid:8679082
Chen L et al. [Effect of puerarin on cerebral blood flow in dogs]. 1995 Zhongguo Zhong Yao Za Zhi pmid:8679097
Xu XH [Effects of puerarin on fatty superoxide in aged mice induced by D-galactose]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15015271
Wang L et al. [Protective effect of puerarin on acute cerebral ischemia in rats]. 1997 Zhongguo Zhong Yao Za Zhi pmid:11243176
Yang H et al. [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18161289
Liu R et al. [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18161305
Lv JH et al. [Improvement effects of puerarin on glycated brain damages in rats induced by D-galactose]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048591
Zhu H et al. [Application and characteristics of macroreticular resin in purification study of different effective ingredients in Chinese medicines]. 1998 Zhongguo Zhong Yao Za Zhi pmid:11599359
Liu Q et al. [Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction]. 1999 Zhongguo Zhong Yao Za Zhi pmid:12205891