| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Feng ZQ et al. | The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury. | 2010 | J Asian Nat Prod Res | pmid:20924897 |
| Li J et al. | Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. | 2010 | Eur. J. Pharmacol. | pmid:20868658 |
| Zhang W et al. | Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. | 2010 | Eur. J. Pharmacol. | pmid:20869961 |
| Zhang HY et al. | [The protective effect of puerarin on Abeta(25-35)-induced PC12 cell injury]. | 2010 | Zhong Yao Cai | pmid:20873562 |
| Zhu L et al. | [Molecular mechanism of protective effect of puerarin solid lipid nanoparticle on cerebral ischemia-reperfusion injury in gerbils]. | 2010 | Zhong Yao Cai | pmid:21548369 |
| Boonchird C et al. | Differential binding with ERalpha and ERbeta of the phytoestrogen-rich plant Pueraria mirifica. | 2010 | Braz. J. Med. Biol. Res. | pmid:20027484 |
| Yang L and Tan T | An enhanced adsorption in puerarin retention on oligo-beta-cyclodextrin grafted poly(glycidyl methacrylate) media. | 2010 | Appl. Biochem. Biotechnol. | pmid:19067245 |
| Zhu LH et al. | Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling. | 2010 | Free Radic. Biol. Med. | pmid:19854265 |
| Gu L et al. | Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis. | 2010 | Planta Med. | pmid:19918715 |
| Luo CF et al. | Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20006564 |
| Hu W et al. | Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. | 2010 | Pharmacology | pmid:20016245 |
| Shao HM et al. | [Inhibitory effect of flavonoids of puerarin on proliferation of different human acute myeloid leukemia cell lines in vitro]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20416155 |
| Tang YH et al. | [Apoptosis of NB4 cells induced by flavonoids of puerarin in vitro]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20416161 |
| Gao C et al. | Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats. | 2010 | J. Pharm. Pharmacol. | pmid:20487220 |
| Zhang H et al. | Investigation of the inclusions of puerarin and daidzin with beta-cyclodextrin by molecular dynamics simulation. | 2010 | J Phys Chem B | pmid:20297792 |
| Yu C et al. | Permeabilization of Microbacterium oxylans shifts the conversion of puerarin from puerarin-7-O-glucoside to puerarin-7-O-fructoside. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19943046 |
| Liao XH et al. | [Effect of major components of maijunan tablets on the transport of hydrochlorothiazide in Caco-2 cell monolayer model]. | 2010 | Yao Xue Xue Bao | pmid:21351458 |
| Guo D et al. | [Study on pharmacokinetics and biodistribution of pur derivative nanopaticles in mice]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21355276 |
| Li BJ et al. | [Fingerprints of Tongmai Keli by HPLC-DAD-MS]. | 2010 | Yao Xue Xue Bao | pmid:21361041 |
| Yao H et al. | [The role of mitochondrial K+ channels in the cardioprotection of puerarin against hypoxia/reoxygenation injury in rats]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21328988 |
| Liu J et al. | An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients. | 2010 | Biomed. Chromatogr. | pmid:20058327 |
| Han RM et al. | Fast regeneration of carotenoids from radical cations by isoflavonoid dianions: importance of the carotenoid keto group for electron transfer. | 2010 | J Phys Chem A | pmid:19957978 |
| Xu J et al. | Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release. | 2010 | Acta Biomater | pmid:19619677 |
| Wong RW and Rabie AB | Effect of bio-oss collagen and collagen matrix on bone formation. | 2010 | Open Biomed Eng J | pmid:20461225 |
| Wang MS et al. | Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. | 2010 | BMC Neurosci | pmid:20433710 |
| Yao M et al. | Quantitative analysis of two isoflavones in Pueraria lobata flowers from eleven Chinese provinces using high performance liquid chromatography. | 2010 | Chin Med | pmid:20416072 |
| Gokara M et al. | Molecular interaction studies of trimethoxy flavone with human serum albumin. | 2010 | PLoS ONE | pmid:20098677 |
| Hao LN et al. | Effect of puerarin on retinal pigment epithelial cells apoptosis induced partly by peroxynitrite via Fas/FasL pathway. | 2010 | Int J Ophthalmol | pmid:22553574 |
| Lee IK et al. | Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. | 2010 | Int J Mol Sci | pmid:21614182 |
| O'Brien KA | Alternative perspectives: how chinese medicine understands hypercholesterolemia. | 2010 | Cholesterol | pmid:21490916 |
| Patel RP and Barnes S | Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease. | 2010 | PPAR Res | pmid:21461045 |
| Meng XH et al. | Puerarin protects against high glucose-induced acute vascular dysfunction: role of heme oxygenase-1 in rat thoracic aorta. | 2009 Mar-Apr | Vascul. Pharmacol. | pmid:19073281 |
| Li Q et al. | Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy. | 2009 Jan-Feb | Natl Med J India | pmid:19761151 |
| Zhang BQ and Wang YL | [Effects of puerarin on hippocampal synaptic long term potentiation in vascular dementia rats]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21155222 |
| Zheng P et al. | Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. | 2009 | Am. J. Chin. Med. | pmid:19222113 |
| Zhu CQ et al. | [Preparation technology of Zhangyanming dispersible tablet and determination of puerarin by HPLC]. | 2009 | Zhong Yao Cai | pmid:19771855 |
| Han J et al. | [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19771877 |
| Xu C et al. | Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat. | 2009 | Brain Res. Bull. | pmid:19744545 |
| Cheng YF et al. | Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP(+)-elicited apoptosis. | 2009 | Neurosci. Res. | pmid:19022306 |
| Wang Y et al. | Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19493706 |
| Zhu S et al. | Preparation of a super-long two column chromatography system and its application in separating glycosylated puerarin. | 2009 | Biomed. Chromatogr. | pmid:19603387 |
| Pan ZY et al. | The myocardial protective effects of puerarin on STZ-induced diabetic rats. | 2009 | Fen Zi Xi Bao Sheng Wu Xue Bao | pmid:19537197 |
| Chen CC and Chan WH | Impact effects of puerarin on mouse embryonic development. | 2009 | Reprod. Toxicol. | pmid:19646524 |
| Yue PF et al. | The study on the entrapment efficiency and in vitro release of puerarin submicron emulsion. | 2009 | AAPS PharmSciTech | pmid:19381837 |
| Han S | Determination of puerarin by capillary electrophoresis with chemiluminescence detection. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19342316 |
| Zhang D et al. | [Isoflavones from vines of Pueraria lobata]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20353004 |
| Jin G et al. | [Effects of puerarin on expression of apelin and its receptor of 2K1C renal hypertension rats]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20353015 |
| Yang L et al. | [Screening and identification of a fungal strain functioning in hydroxylation of puerarin]. | 2009 | Wei Sheng Wu Xue Bao | pmid:20222440 |
| Jiang XX et al. | [Effect of puerarin preconditioning on cytokine levels in patients undergoing cardiopulmonary bypass in perioperative period]. | 2009 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:20214329 |
| Zhang X et al. | [Pharmacokinetics of puerarin and hydrochlorothiazide from maijunan tablets in rats]. | 2009 | Yao Xue Xue Bao | pmid:20055185 |